HUBUNGAN KADAR SERUM MATRIX METALLOPROTEINASE-9 TERHADAP KEJADIAN GAGAL JANTUNG AKUT SEBAGAI KOMPLIKASI SINDROMA KORONER AKUT
Background: Acute heart failure (AHF) after acute coronary syndrome (ACS) is the biggest complication with a poor prognosis in a long term. The influence of MMP-9 as proteolytic enzyme that degrades extracellular matrix in remodeling left ventricle was recognized. However, according to researcher�...
| Päätekijät: | , |
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| Aineistotyyppi: | Opinnäyte |
| Julkaistu: |
[Yogyakarta] : Universitas Gadjah Mada
2012
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| Aiheet: |
| _version_ | 1826045359669903360 |
|---|---|
| author | , Sasongko Hadipurnomo, dr , dr. Budi Yuli Setianto, SpPD-KKV, SpJP(K), |
| author_facet | , Sasongko Hadipurnomo, dr , dr. Budi Yuli Setianto, SpPD-KKV, SpJP(K), |
| author_sort | , Sasongko Hadipurnomo, dr |
| collection | UGM |
| description | Background: Acute heart failure (AHF) after acute coronary syndrome (ACS) is the
biggest complication with a poor prognosis in a long term. The influence of MMP-9
as proteolytic enzyme that degrades extracellular matrix in remodeling left ventricle
was recognized. However, according to researcher�s knowledge, evaluation of the
MMP-9 as a predictor of AHF after ACS was never reported.
Objective: To find out the serum level of MMP-9 in ACS with AHF higher than that
without it, as well as to find out the level of MMP-9 with risk of AHF after ACS.
Method: The study used a cross-sectional study. Samples were collected by using a
consecutive sampling technique among patients with ACS treated in ICCU of Public
Hospital Dr Sardjito Yogyakarta, since June 2008 to August 2010. Questionnaires
were used to collect sample raw data. The level of MMP-9 was examined a time at
admission in ICCU before trombolysis was done. The heart failure had Killip II- IV
scores. Factors influencing the incidence was analyzed by using multivariate analysis
technique. A significance level was at p< 0.05. The relative risk of acute heart failure
at a certain level of MMP-9 (from cut-off value) was obtained after it was adjusted.
Result: Among 122 subjects, 75 was without AHF and 47 with AHF. Median of the
level of MMP-9 in the whole sample of ACS was 1248.55 ng/mL with a minimum of
170.50 ng/mL and maximum of 3058.40 ng/mL. Moreover, the level of MMP-9 in
ACS with AHF (1700.81±740.43 ng/mL) was significantly higher than ACS without
AHF (1189.55±654.60 ng/mL) with p value = 0.000. Independent risk factor after
the multivariate analysis was done indicates the level of MMP-9 above 1444 ng/mL
(RR= 4.2) and the location of anterior infarction (RR= 2.9).
Conclusion: In patients with ACS treated in ICCU of RSUP Dr Sardjito, the level
of MMP-9 with AHF was higher than that without it. If the level of MMP-9 above
1444 ng/mL, the possibility of AHF was 4.2 times. |
| first_indexed | 2024-03-13T22:35:58Z |
| format | Thesis |
| id | oai:generic.eprints.org:98414 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T22:35:58Z |
| publishDate | 2012 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:984142016-03-04T08:48:52Z https://repository.ugm.ac.id/98414/ HUBUNGAN KADAR SERUM MATRIX METALLOPROTEINASE-9 TERHADAP KEJADIAN GAGAL JANTUNG AKUT SEBAGAI KOMPLIKASI SINDROMA KORONER AKUT , Sasongko Hadipurnomo, dr , dr. Budi Yuli Setianto, SpPD-KKV, SpJP(K), ETD Background: Acute heart failure (AHF) after acute coronary syndrome (ACS) is the biggest complication with a poor prognosis in a long term. The influence of MMP-9 as proteolytic enzyme that degrades extracellular matrix in remodeling left ventricle was recognized. However, according to researcher�s knowledge, evaluation of the MMP-9 as a predictor of AHF after ACS was never reported. Objective: To find out the serum level of MMP-9 in ACS with AHF higher than that without it, as well as to find out the level of MMP-9 with risk of AHF after ACS. Method: The study used a cross-sectional study. Samples were collected by using a consecutive sampling technique among patients with ACS treated in ICCU of Public Hospital Dr Sardjito Yogyakarta, since June 2008 to August 2010. Questionnaires were used to collect sample raw data. The level of MMP-9 was examined a time at admission in ICCU before trombolysis was done. The heart failure had Killip II- IV scores. Factors influencing the incidence was analyzed by using multivariate analysis technique. A significance level was at p< 0.05. The relative risk of acute heart failure at a certain level of MMP-9 (from cut-off value) was obtained after it was adjusted. Result: Among 122 subjects, 75 was without AHF and 47 with AHF. Median of the level of MMP-9 in the whole sample of ACS was 1248.55 ng/mL with a minimum of 170.50 ng/mL and maximum of 3058.40 ng/mL. Moreover, the level of MMP-9 in ACS with AHF (1700.81±740.43 ng/mL) was significantly higher than ACS without AHF (1189.55±654.60 ng/mL) with p value = 0.000. Independent risk factor after the multivariate analysis was done indicates the level of MMP-9 above 1444 ng/mL (RR= 4.2) and the location of anterior infarction (RR= 2.9). Conclusion: In patients with ACS treated in ICCU of RSUP Dr Sardjito, the level of MMP-9 with AHF was higher than that without it. If the level of MMP-9 above 1444 ng/mL, the possibility of AHF was 4.2 times. [Yogyakarta] : Universitas Gadjah Mada 2012 Thesis NonPeerReviewed , Sasongko Hadipurnomo, dr and , dr. Budi Yuli Setianto, SpPD-KKV, SpJP(K), (2012) HUBUNGAN KADAR SERUM MATRIX METALLOPROTEINASE-9 TERHADAP KEJADIAN GAGAL JANTUNG AKUT SEBAGAI KOMPLIKASI SINDROMA KORONER AKUT. UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=54636 |
| spellingShingle | ETD , Sasongko Hadipurnomo, dr , dr. Budi Yuli Setianto, SpPD-KKV, SpJP(K), HUBUNGAN KADAR SERUM MATRIX METALLOPROTEINASE-9 TERHADAP KEJADIAN GAGAL JANTUNG AKUT SEBAGAI KOMPLIKASI SINDROMA KORONER AKUT |
| title | HUBUNGAN KADAR SERUM MATRIX METALLOPROTEINASE-9 TERHADAP KEJADIAN GAGAL JANTUNG AKUT SEBAGAI KOMPLIKASI SINDROMA KORONER AKUT |
| title_full | HUBUNGAN KADAR SERUM MATRIX METALLOPROTEINASE-9 TERHADAP KEJADIAN GAGAL JANTUNG AKUT SEBAGAI KOMPLIKASI SINDROMA KORONER AKUT |
| title_fullStr | HUBUNGAN KADAR SERUM MATRIX METALLOPROTEINASE-9 TERHADAP KEJADIAN GAGAL JANTUNG AKUT SEBAGAI KOMPLIKASI SINDROMA KORONER AKUT |
| title_full_unstemmed | HUBUNGAN KADAR SERUM MATRIX METALLOPROTEINASE-9 TERHADAP KEJADIAN GAGAL JANTUNG AKUT SEBAGAI KOMPLIKASI SINDROMA KORONER AKUT |
| title_short | HUBUNGAN KADAR SERUM MATRIX METALLOPROTEINASE-9 TERHADAP KEJADIAN GAGAL JANTUNG AKUT SEBAGAI KOMPLIKASI SINDROMA KORONER AKUT |
| title_sort | hubungan kadar serum matrix metalloproteinase 9 terhadap kejadian gagal jantung akut sebagai komplikasi sindroma koroner akut |
| topic | ETD |
| work_keys_str_mv | AT sasongkohadipurnomodr hubungankadarserummatrixmetalloproteinase9terhadapkejadiangagaljantungakutsebagaikomplikasisindromakoronerakut AT drbudiyulisetiantosppdkkvspjpk hubungankadarserummatrixmetalloproteinase9terhadapkejadiangagaljantungakutsebagaikomplikasisindromakoronerakut |