| 总结: | Reconstruction of bone defects remains an important problem in oral and
maxillofacial surgery. Restoration of bone defect sites with autogenous cancellous bone
grafting materials is a valuable approach to the solution of this problem. Bone defects
may be regained by osteogenesis, osteoinduction, osteoconduction or guided bone
regeneration. Hyaluronic acid (HA) is one of the essential components of extracellular
matrix, which plays a predominant role in tissue morphogenesis, cell migration,
differentiation, and adhesion.
The study aims to find out the effect of 0,8% hyaluronic acid jelly application
towards bone recovery process following mandibular bone defect by observing new
bone formation.
In this study, two cavities of 3mm diameter and depth have been created in the
mandibular bone of 12 mature guinea pig in accordance with the principles of general
surgery. One of the cavities in the mandibular bone is filled with 0,8% hyaluronic acid
jelly and autogenous cancellous bone graft and the other is filled with only autogenous
cancellous bone graft, for the purpose of control. On the 7
th
and 14
th
days, guinea pig
have been sacrificed in equal numbers and defective regions have been extracted. The
Mann-Whitney U test and Kruskal�Wallis test was applied to the data obtained in the
result of histopathologic survey of specimens.
The result of study suggest the cavities that have been filled with 0,8%
hyaluronic acid jelly and autogenous cancellous bone graft give significant effects to
the speed of bone defect recovery following mandibular bone defect
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