PERBANDINGAN ONSET DAN KEJADIAN HIPOTENSI ANTARA PROPOFOL LCT DENGAN PROPOFOL MCT/LCT
Background. Propofol is an intravenous anesthetic drug that most commonly used today. Propofol used for induction, maintenance of anesthesia and sedation both inside and outside the operating room. Induction of anesthesia with propofol is associated with several side effects such as hypotension and...
| Main Authors: | , |
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| Format: | Thesis |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
2012
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| _version_ | 1826045597800464384 |
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| author | , Julita Ramayani , Dr. Bambang Suryono S, SpAn. MKes. KIC. KNA |
| author_facet | , Julita Ramayani , Dr. Bambang Suryono S, SpAn. MKes. KIC. KNA |
| author_sort | , Julita Ramayani |
| collection | UGM |
| description | Background. Propofol is an intravenous anesthetic drug that most commonly
used today. Propofol used for induction, maintenance of anesthesia and sedation
both inside and outside the operating room. Induction of anesthesia with propofol
is associated with several side effects such as hypotension and pain of injection.
Propofol formula was initially used a concentration of 10 mg/ml in long-chain
triglyceride (LCT) fatty emulsion. Propofol MCT/LCT has been introduce since
1995 to reduce moderate to severe pain due to injection of propofol. Since
concentration of free propofol in propofol MCT/LCT lower than propofol LCT, it
will affect the potency and onset time. More free drug fraction in plasma means
the drug more potent and rapid onset.
Purpose. To determine the onset and incidence of hypotension between propofol
LCT and propofol MCT/LCT.
Methods. The design of the study was a randomized double blind controlled trial
( RCT). Total study subjects were 66 patients, divided into two groups, each
group consist of 33 patients. Group A was the group who received propofol LCT
2 mg/kg and group B was the group who received propofol MCT/LCT 2 mg/kg.
Inclusion criteria were men and women aged 18-60 years, ASA I and II, elective
surgery procedures other than neurosurgery, cardiac surgery and cesarean section,
and BMI> 20 and <30 kg/m2. The exclusion criteria were patients with
cardiovascular disorders such as heart disease, hypertension, patients with
endocrine disorders such as diabetes mellitus, hyperthyroidism, hypothyroidism,
impaired renal function, patients taking antiarrhythmic drugs, vasopresor,
vasodilator and a history of allergy to propofol.
Result. There were no significant differences in the onset of propofol between
group A and group B either by eyelash reflex disappeared (p = 0.339) or hand grip
opened (p = 0.783). There were also no significant difference in both systolic and
diastolic blood pressure (p> 0.05).
Summary. Propofol LCT with more free drugs than propofol MCT/LCT, did not
have a faster onset and larger hypotension effect than propofol MCT/LCT. |
| first_indexed | 2024-03-13T22:39:34Z |
| format | Thesis |
| id | oai:generic.eprints.org:99573 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T22:39:34Z |
| publishDate | 2012 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:995732016-03-04T08:47:18Z https://repository.ugm.ac.id/99573/ PERBANDINGAN ONSET DAN KEJADIAN HIPOTENSI ANTARA PROPOFOL LCT DENGAN PROPOFOL MCT/LCT , Julita Ramayani , Dr. Bambang Suryono S, SpAn. MKes. KIC. KNA ETD Background. Propofol is an intravenous anesthetic drug that most commonly used today. Propofol used for induction, maintenance of anesthesia and sedation both inside and outside the operating room. Induction of anesthesia with propofol is associated with several side effects such as hypotension and pain of injection. Propofol formula was initially used a concentration of 10 mg/ml in long-chain triglyceride (LCT) fatty emulsion. Propofol MCT/LCT has been introduce since 1995 to reduce moderate to severe pain due to injection of propofol. Since concentration of free propofol in propofol MCT/LCT lower than propofol LCT, it will affect the potency and onset time. More free drug fraction in plasma means the drug more potent and rapid onset. Purpose. To determine the onset and incidence of hypotension between propofol LCT and propofol MCT/LCT. Methods. The design of the study was a randomized double blind controlled trial ( RCT). Total study subjects were 66 patients, divided into two groups, each group consist of 33 patients. Group A was the group who received propofol LCT 2 mg/kg and group B was the group who received propofol MCT/LCT 2 mg/kg. Inclusion criteria were men and women aged 18-60 years, ASA I and II, elective surgery procedures other than neurosurgery, cardiac surgery and cesarean section, and BMI> 20 and <30 kg/m2. The exclusion criteria were patients with cardiovascular disorders such as heart disease, hypertension, patients with endocrine disorders such as diabetes mellitus, hyperthyroidism, hypothyroidism, impaired renal function, patients taking antiarrhythmic drugs, vasopresor, vasodilator and a history of allergy to propofol. Result. There were no significant differences in the onset of propofol between group A and group B either by eyelash reflex disappeared (p = 0.339) or hand grip opened (p = 0.783). There were also no significant difference in both systolic and diastolic blood pressure (p> 0.05). Summary. Propofol LCT with more free drugs than propofol MCT/LCT, did not have a faster onset and larger hypotension effect than propofol MCT/LCT. [Yogyakarta] : Universitas Gadjah Mada 2012 Thesis NonPeerReviewed , Julita Ramayani and , Dr. Bambang Suryono S, SpAn. MKes. KIC. KNA (2012) PERBANDINGAN ONSET DAN KEJADIAN HIPOTENSI ANTARA PROPOFOL LCT DENGAN PROPOFOL MCT/LCT. UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=56035 |
| spellingShingle | ETD , Julita Ramayani , Dr. Bambang Suryono S, SpAn. MKes. KIC. KNA PERBANDINGAN ONSET DAN KEJADIAN HIPOTENSI ANTARA PROPOFOL LCT DENGAN PROPOFOL MCT/LCT |
| title | PERBANDINGAN ONSET DAN KEJADIAN HIPOTENSI
ANTARA PROPOFOL LCT DENGAN PROPOFOL MCT/LCT |
| title_full | PERBANDINGAN ONSET DAN KEJADIAN HIPOTENSI
ANTARA PROPOFOL LCT DENGAN PROPOFOL MCT/LCT |
| title_fullStr | PERBANDINGAN ONSET DAN KEJADIAN HIPOTENSI
ANTARA PROPOFOL LCT DENGAN PROPOFOL MCT/LCT |
| title_full_unstemmed | PERBANDINGAN ONSET DAN KEJADIAN HIPOTENSI
ANTARA PROPOFOL LCT DENGAN PROPOFOL MCT/LCT |
| title_short | PERBANDINGAN ONSET DAN KEJADIAN HIPOTENSI
ANTARA PROPOFOL LCT DENGAN PROPOFOL MCT/LCT |
| title_sort | perbandingan onset dan kejadian hipotensi antara propofol lct dengan propofol mct lct |
| topic | ETD |
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