Comparative study on mitogen activated protein kinase of Plasmodium species by using in silico method / Mohd Fakharul Zaman Raja Yahya and Hasidah Mohd Sidek
Malaria parasites, Plasmodium can infect a wide range of hosts including humans and rodents. There are two copies of mitogen activated protein kinases (MAPKs) in Plasmodium, namely MAPK1 and MAPK2. The MAPKs have been studied extensively in the human Plasmodium, P. falciparum. However, the MAPKs fro...
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| Format: | Article |
| Language: | English |
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Research Management Institute
2012
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| Online Access: | https://ir.uitm.edu.my/id/eprint/12954/1/AJ_MOHD%20FAKHARUL%20ZAMAN%20RAJA%20YAHYA%20SRJ%2012%201.pdf |
| _version_ | 1825734081120305152 |
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| author | Raja Yahya, Mohd Fakharul Zaman Mohd Sidek, Hasidah |
| author_facet | Raja Yahya, Mohd Fakharul Zaman Mohd Sidek, Hasidah |
| author_sort | Raja Yahya, Mohd Fakharul Zaman |
| collection | UITM |
| description | Malaria parasites, Plasmodium can infect a wide range of hosts including humans and rodents. There are two copies of mitogen activated protein kinases (MAPKs) in Plasmodium, namely MAPK1 and MAPK2. The MAPKs have been studied extensively in the human Plasmodium, P. falciparum. However, the MAPKs from other Plasmodium species have
not been characterized and it is therefore the premise of presented study to characterize the MAPKs from other Plasmodium species-P. vivax, P. knowlesi, P. berghei, P. chabaudi and P.yoelli using a series of publicly available bioinformatic tools. In silico data indicates that all Plasmodium MAPKs are nuclear-localizedandcontain both a nuclear localization signal (NLS) anda Leucine-rich nuclear export signal (NES). The activation motifs ofTDYand TSH werefound to befully conserved in Plasmodium MAPK1
and MAPK2, respectively. |
| first_indexed | 2024-03-06T01:26:28Z |
| format | Article |
| id | oai:ir.uitm.edu.my:12954 |
| institution | Universiti Teknologi MARA |
| language | English |
| last_indexed | 2024-03-06T01:26:28Z |
| publishDate | 2012 |
| publisher | Research Management Institute |
| record_format | dspace |
| spelling | oai:ir.uitm.edu.my:129542017-02-21T03:53:15Z https://ir.uitm.edu.my/id/eprint/12954/ Comparative study on mitogen activated protein kinase of Plasmodium species by using in silico method / Mohd Fakharul Zaman Raja Yahya and Hasidah Mohd Sidek srj Raja Yahya, Mohd Fakharul Zaman Mohd Sidek, Hasidah Protein kinases Plasmodium falciparum Malaria Malaria parasites, Plasmodium can infect a wide range of hosts including humans and rodents. There are two copies of mitogen activated protein kinases (MAPKs) in Plasmodium, namely MAPK1 and MAPK2. The MAPKs have been studied extensively in the human Plasmodium, P. falciparum. However, the MAPKs from other Plasmodium species have not been characterized and it is therefore the premise of presented study to characterize the MAPKs from other Plasmodium species-P. vivax, P. knowlesi, P. berghei, P. chabaudi and P.yoelli using a series of publicly available bioinformatic tools. In silico data indicates that all Plasmodium MAPKs are nuclear-localizedandcontain both a nuclear localization signal (NLS) anda Leucine-rich nuclear export signal (NES). The activation motifs ofTDYand TSH werefound to befully conserved in Plasmodium MAPK1 and MAPK2, respectively. Research Management Institute 2012 Article PeerReviewed text en https://ir.uitm.edu.my/id/eprint/12954/1/AJ_MOHD%20FAKHARUL%20ZAMAN%20RAJA%20YAHYA%20SRJ%2012%201.pdf Comparative study on mitogen activated protein kinase of Plasmodium species by using in silico method / Mohd Fakharul Zaman Raja Yahya and Hasidah Mohd Sidek. (2012) Scientific Research Journal <https://ir.uitm.edu.my/view/publication/Scientific_Research_Journal/>, 9 (1). pp. 1-14. ISSN 1675-7009 https://srj.uitm.edu.my/ |
| spellingShingle | Protein kinases Plasmodium falciparum Malaria Raja Yahya, Mohd Fakharul Zaman Mohd Sidek, Hasidah Comparative study on mitogen activated protein kinase of Plasmodium species by using in silico method / Mohd Fakharul Zaman Raja Yahya and Hasidah Mohd Sidek |
| title | Comparative study on mitogen activated protein kinase of Plasmodium species by using in silico method / Mohd Fakharul Zaman Raja Yahya and Hasidah Mohd Sidek |
| title_full | Comparative study on mitogen activated protein kinase of Plasmodium species by using in silico method / Mohd Fakharul Zaman Raja Yahya and Hasidah Mohd Sidek |
| title_fullStr | Comparative study on mitogen activated protein kinase of Plasmodium species by using in silico method / Mohd Fakharul Zaman Raja Yahya and Hasidah Mohd Sidek |
| title_full_unstemmed | Comparative study on mitogen activated protein kinase of Plasmodium species by using in silico method / Mohd Fakharul Zaman Raja Yahya and Hasidah Mohd Sidek |
| title_short | Comparative study on mitogen activated protein kinase of Plasmodium species by using in silico method / Mohd Fakharul Zaman Raja Yahya and Hasidah Mohd Sidek |
| title_sort | comparative study on mitogen activated protein kinase of plasmodium species by using in silico method mohd fakharul zaman raja yahya and hasidah mohd sidek |
| topic | Protein kinases Plasmodium falciparum Malaria |
| url | https://ir.uitm.edu.my/id/eprint/12954/1/AJ_MOHD%20FAKHARUL%20ZAMAN%20RAJA%20YAHYA%20SRJ%2012%201.pdf |
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