Synthesis, characterization and neurotoxicity screening of schiff base ligands derived from 1,8-Diaminonaphthalene and their Cu(ii), Co(ii), Ni(ii) and Zn(ii) complexes / Ahmad Fauzi Abu Bakar
Five Schiff base ligands were successful synthesized from 1,8-diaminonaphthalene with 2-hydroacetophenone, 5-bromo-2-hydroxyacetophenone, salicyldehyde, 2-4,dihydroxybenayldehyde and 3-hydroxy-4-methoxybenzaldehyde in the ratio 1:2. Twenty complexes of Cu(II), Co(II), Ni(II) and Zn(II) with the five...
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| Format: | Thesis |
| Language: | English |
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2013
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| Online Access: | https://ir.uitm.edu.my/id/eprint/15528/1/TM_AHMAD%20FAUZI%20ABU%20BAKAR%20AS%2013_5.pdf |
| _version_ | 1825734486365569024 |
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| author | Abu Bakar, Ahmad Fauzi |
| author_facet | Abu Bakar, Ahmad Fauzi |
| author_sort | Abu Bakar, Ahmad Fauzi |
| collection | UITM |
| description | Five Schiff base ligands were successful synthesized from 1,8-diaminonaphthalene with 2-hydroacetophenone, 5-bromo-2-hydroxyacetophenone, salicyldehyde, 2-4,dihydroxybenayldehyde and 3-hydroxy-4-methoxybenzaldehyde in the ratio 1:2. Twenty complexes of Cu(II), Co(II), Ni(II) and Zn(II) with the five ligands were obtained with 1:1 ratio of ligand:metal. The chemical structures were investigated and elucidated using elemental analysis (C,H,N), infrared spectroscopy, 1 H and 13C nuclear magnetic resonance spectroscopy, ultraviolet-visible spectroscopy, melting point measurement and magnetic susceptibility measurement. The paramagnetic Cu(II) and Co(II) complexes were observed to display v(C=N) band in the range 1601 to 1638 cm'1, while those of the diamagnetic Ni(II) and Zn(II) complexes displayed v(C=N) band in the region 1587 to 1638 cm'1. From the effective magnetic moment (|^eff) values, it was indicate that the nickel(II) complexes adopted square planar geometry while all the cobalt(II) complexes were tetrahedral. The representative compounds of CoLl and LI showed UV-Vis absorption bands at 260 to 332 nm assignable to n—>n* transition of the aromatic systems. The band at 298 nm for ligand was likely due to n—>n* and tt— electron transitions of the conjugated C=C chromophore of the naphthalene and phenyl moieties. Absorption for cobalt(II) complex showed a bathocromical shift to the free ligand, caused by the coordination of metal to the ligand, in agreement with the IR spectral results. The neurotoxicity screening on treated human neuroblastoma SH-SY5Y cell lines revealed that the compound were not toxic to the cell line. |
| first_indexed | 2024-03-06T01:32:28Z |
| format | Thesis |
| id | oai:ir.uitm.edu.my:15528 |
| institution | Universiti Teknologi MARA |
| language | English |
| last_indexed | 2024-03-06T01:32:28Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oai:ir.uitm.edu.my:155282022-04-18T02:11:29Z https://ir.uitm.edu.my/id/eprint/15528/ Synthesis, characterization and neurotoxicity screening of schiff base ligands derived from 1,8-Diaminonaphthalene and their Cu(ii), Co(ii), Ni(ii) and Zn(ii) complexes / Ahmad Fauzi Abu Bakar Abu Bakar, Ahmad Fauzi Bioactive compounds Five Schiff base ligands were successful synthesized from 1,8-diaminonaphthalene with 2-hydroacetophenone, 5-bromo-2-hydroxyacetophenone, salicyldehyde, 2-4,dihydroxybenayldehyde and 3-hydroxy-4-methoxybenzaldehyde in the ratio 1:2. Twenty complexes of Cu(II), Co(II), Ni(II) and Zn(II) with the five ligands were obtained with 1:1 ratio of ligand:metal. The chemical structures were investigated and elucidated using elemental analysis (C,H,N), infrared spectroscopy, 1 H and 13C nuclear magnetic resonance spectroscopy, ultraviolet-visible spectroscopy, melting point measurement and magnetic susceptibility measurement. The paramagnetic Cu(II) and Co(II) complexes were observed to display v(C=N) band in the range 1601 to 1638 cm'1, while those of the diamagnetic Ni(II) and Zn(II) complexes displayed v(C=N) band in the region 1587 to 1638 cm'1. From the effective magnetic moment (|^eff) values, it was indicate that the nickel(II) complexes adopted square planar geometry while all the cobalt(II) complexes were tetrahedral. The representative compounds of CoLl and LI showed UV-Vis absorption bands at 260 to 332 nm assignable to n—>n* transition of the aromatic systems. The band at 298 nm for ligand was likely due to n—>n* and tt— electron transitions of the conjugated C=C chromophore of the naphthalene and phenyl moieties. Absorption for cobalt(II) complex showed a bathocromical shift to the free ligand, caused by the coordination of metal to the ligand, in agreement with the IR spectral results. The neurotoxicity screening on treated human neuroblastoma SH-SY5Y cell lines revealed that the compound were not toxic to the cell line. 2013-08 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/15528/1/TM_AHMAD%20FAUZI%20ABU%20BAKAR%20AS%2013_5.pdf Synthesis, characterization and neurotoxicity screening of schiff base ligands derived from 1,8-Diaminonaphthalene and their Cu(ii), Co(ii), Ni(ii) and Zn(ii) complexes / Ahmad Fauzi Abu Bakar. (2013) Masters thesis, thesis, Universiti Teknologi MARA. <http://terminalib.uitm.edu.my/15528.pdf> |
| spellingShingle | Bioactive compounds Abu Bakar, Ahmad Fauzi Synthesis, characterization and neurotoxicity screening of schiff base ligands derived from 1,8-Diaminonaphthalene and their Cu(ii), Co(ii), Ni(ii) and Zn(ii) complexes / Ahmad Fauzi Abu Bakar |
| title | Synthesis, characterization and neurotoxicity screening of schiff base ligands derived from 1,8-Diaminonaphthalene and their Cu(ii), Co(ii), Ni(ii) and Zn(ii) complexes / Ahmad Fauzi Abu Bakar |
| title_full | Synthesis, characterization and neurotoxicity screening of schiff base ligands derived from 1,8-Diaminonaphthalene and their Cu(ii), Co(ii), Ni(ii) and Zn(ii) complexes / Ahmad Fauzi Abu Bakar |
| title_fullStr | Synthesis, characterization and neurotoxicity screening of schiff base ligands derived from 1,8-Diaminonaphthalene and their Cu(ii), Co(ii), Ni(ii) and Zn(ii) complexes / Ahmad Fauzi Abu Bakar |
| title_full_unstemmed | Synthesis, characterization and neurotoxicity screening of schiff base ligands derived from 1,8-Diaminonaphthalene and their Cu(ii), Co(ii), Ni(ii) and Zn(ii) complexes / Ahmad Fauzi Abu Bakar |
| title_short | Synthesis, characterization and neurotoxicity screening of schiff base ligands derived from 1,8-Diaminonaphthalene and their Cu(ii), Co(ii), Ni(ii) and Zn(ii) complexes / Ahmad Fauzi Abu Bakar |
| title_sort | synthesis characterization and neurotoxicity screening of schiff base ligands derived from 1 8 diaminonaphthalene and their cu ii co ii ni ii and zn ii complexes ahmad fauzi abu bakar |
| topic | Bioactive compounds |
| url | https://ir.uitm.edu.my/id/eprint/15528/1/TM_AHMAD%20FAUZI%20ABU%20BAKAR%20AS%2013_5.pdf |
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