Use of microwave technology in transdermal drug delivery / Nor Khaizan Anuar
The project focused on the use of microwave in controlling drug release from film matrix and modifying skin barrier for transdermal drug delivery. With reference to controlledrelease application, the effects of microwave on drug release properties of pectin films carrying sulfanilamide (P-SN), sulfa...
| Main Author: | |
|---|---|
| Format: | Book Section |
| Language: | English |
| Published: |
Institute of Graduate Studies, UiTM
2013
|
| Subjects: | |
| Online Access: | https://ir.uitm.edu.my/id/eprint/19130/1/ABS_NOR%20KHAIZAN%20ANUAR%20TDRA%20VOL%204%20IGS%2013.pdf |
| _version_ | 1825735160720523264 |
|---|---|
| author | Anuar, Nor Khaizan |
| author_facet | Anuar, Nor Khaizan |
| author_sort | Anuar, Nor Khaizan |
| collection | UITM |
| description | The project focused on the use of microwave in controlling drug release from film matrix and modifying skin barrier for transdermal drug delivery. With reference to controlledrelease application, the effects of microwave on drug release properties of pectin films carrying sulfanilamide (P-SN), sulfathiazole (P-ST) and sulfamerazine (P-SM) of high to low aqueous solubilities were investigated. These films were prepared by solvent-evaporation technique and treated by microwave at 80 W for 5 to 40 min. Their profiles of drug dissolution, drug content, matrix interaction and matrix crystallinity were determined by drug dissolution testing, drug content assay, differential scanning calorimetry, X-ray diffractometry and scanning electron microscopy techniques. Microwave was found to be able to increase the matrix amorphousness. However, the strength of matrix interaction was accordingly increased thereby lowering the drug release propensity with a greater retardation extent in P-SN films. A gain in amorphous structure did not necessarily increase the drug release of film. Microwave can possibly retard drug release of pectin film carrying water-soluble drug through modulating its state of matrix interaction. In the case of skin barrier modification by microwave, the mechanism of microwave enhancing transdermal permeation of drug from film through its action on skin was investigated. The transdermal drug delivery profiles of pectin film was evaluated against pectin gel with reference to the influences of microwave, as well as chemical permeation enhancer namely oleic acid on skin. Hydrophilic P-SN films and gels, with or without oleic acid (OA), were prepared and subjected to drug release and skin permeation studies… |
| first_indexed | 2024-03-06T01:42:53Z |
| format | Book Section |
| id | oai:ir.uitm.edu.my:19130 |
| institution | Universiti Teknologi MARA |
| language | English |
| last_indexed | 2024-03-06T01:42:53Z |
| publishDate | 2013 |
| publisher | Institute of Graduate Studies, UiTM |
| record_format | dspace |
| spelling | oai:ir.uitm.edu.my:191302018-06-11T04:33:25Z https://ir.uitm.edu.my/id/eprint/19130/ Use of microwave technology in transdermal drug delivery / Nor Khaizan Anuar Anuar, Nor Khaizan Malaysia Materia medica The project focused on the use of microwave in controlling drug release from film matrix and modifying skin barrier for transdermal drug delivery. With reference to controlledrelease application, the effects of microwave on drug release properties of pectin films carrying sulfanilamide (P-SN), sulfathiazole (P-ST) and sulfamerazine (P-SM) of high to low aqueous solubilities were investigated. These films were prepared by solvent-evaporation technique and treated by microwave at 80 W for 5 to 40 min. Their profiles of drug dissolution, drug content, matrix interaction and matrix crystallinity were determined by drug dissolution testing, drug content assay, differential scanning calorimetry, X-ray diffractometry and scanning electron microscopy techniques. Microwave was found to be able to increase the matrix amorphousness. However, the strength of matrix interaction was accordingly increased thereby lowering the drug release propensity with a greater retardation extent in P-SN films. A gain in amorphous structure did not necessarily increase the drug release of film. Microwave can possibly retard drug release of pectin film carrying water-soluble drug through modulating its state of matrix interaction. In the case of skin barrier modification by microwave, the mechanism of microwave enhancing transdermal permeation of drug from film through its action on skin was investigated. The transdermal drug delivery profiles of pectin film was evaluated against pectin gel with reference to the influences of microwave, as well as chemical permeation enhancer namely oleic acid on skin. Hydrophilic P-SN films and gels, with or without oleic acid (OA), were prepared and subjected to drug release and skin permeation studies… Institute of Graduate Studies, UiTM 2013 Book Section PeerReviewed text en https://ir.uitm.edu.my/id/eprint/19130/1/ABS_NOR%20KHAIZAN%20ANUAR%20TDRA%20VOL%204%20IGS%2013.pdf Use of microwave technology in transdermal drug delivery / Nor Khaizan Anuar. (2013) In: The Doctoral Research Abstracts. IPSis Biannual Publication, 4 (4). Institute of Graduate Studies, UiTM, Shah Alam. |
| spellingShingle | Malaysia Materia medica Anuar, Nor Khaizan Use of microwave technology in transdermal drug delivery / Nor Khaizan Anuar |
| title | Use of microwave technology in transdermal drug delivery / Nor Khaizan Anuar |
| title_full | Use of microwave technology in transdermal drug delivery / Nor Khaizan Anuar |
| title_fullStr | Use of microwave technology in transdermal drug delivery / Nor Khaizan Anuar |
| title_full_unstemmed | Use of microwave technology in transdermal drug delivery / Nor Khaizan Anuar |
| title_short | Use of microwave technology in transdermal drug delivery / Nor Khaizan Anuar |
| title_sort | use of microwave technology in transdermal drug delivery nor khaizan anuar |
| topic | Malaysia Materia medica |
| url | https://ir.uitm.edu.my/id/eprint/19130/1/ABS_NOR%20KHAIZAN%20ANUAR%20TDRA%20VOL%204%20IGS%2013.pdf |
| work_keys_str_mv | AT anuarnorkhaizan useofmicrowavetechnologyintransdermaldrugdeliverynorkhaizananuar |