Colon-specific delivery of 5-fluorouracil from zinc pectinate spheroids through in situ intra-capsular ethylcellulose- pectin plug formation / Assad Ali Faraj Elyagoby
Conventional fluid-bed and immersion film coating of hydrophilic zinc pectinate spheroids using ethylcellulose-pectin mixture is met with fast drug release due to hydrophobic ethylcellulose coat detachment. This study explored in situ intra-capsular spheroid coating for colon-specific delivery of 5-...
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| Format: | Book Section |
| Language: | English |
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Institute of Graduate Studies, UiTM
2014
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| Online Access: | https://ir.uitm.edu.my/id/eprint/19620/1/ABS_ASSAD%20ALI%20FARAJ%20ELYAGOBY%20TDRA%20VOL%206%20IGS_14.pdf |
| _version_ | 1796901043743752192 |
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| author | Elyagoby, Assad Ali Faraj |
| author_facet | Elyagoby, Assad Ali Faraj |
| author_sort | Elyagoby, Assad Ali Faraj |
| collection | UITM |
| description | Conventional fluid-bed and immersion film coating of hydrophilic zinc pectinate spheroids using ethylcellulose-pectin mixture is met with fast drug release due to hydrophobic ethylcellulose coat detachment. This study explored in situ intra-capsular spheroid coating for colon-specific delivery of 5-fluorouracil. The solid coating powder was constituted of ethylcellulose and pectin in weight ratios of 11:0 to 2:9. Its weight ratio to spheroids was varied between 2:3 and 3:2. Delayed 5-fluorouracil release was obtained when the weight ratio of ethylcellulose and pectin in coating powder was kept at 8:3, and weight ratio of solid coating powder to spheroids was kept at 3:2 with particle size of ethylcellulose reduced to 22 μm. |
| first_indexed | 2024-03-06T01:44:14Z |
| format | Book Section |
| id | oai:ir.uitm.edu.my:19620 |
| institution | Universiti Teknologi MARA |
| language | English |
| last_indexed | 2024-03-06T01:44:14Z |
| publishDate | 2014 |
| publisher | Institute of Graduate Studies, UiTM |
| record_format | dspace |
| spelling | oai:ir.uitm.edu.my:196202018-06-07T03:00:52Z https://ir.uitm.edu.my/id/eprint/19620/ Colon-specific delivery of 5-fluorouracil from zinc pectinate spheroids through in situ intra-capsular ethylcellulose- pectin plug formation / Assad Ali Faraj Elyagoby Elyagoby, Assad Ali Faraj Malaysia Conventional fluid-bed and immersion film coating of hydrophilic zinc pectinate spheroids using ethylcellulose-pectin mixture is met with fast drug release due to hydrophobic ethylcellulose coat detachment. This study explored in situ intra-capsular spheroid coating for colon-specific delivery of 5-fluorouracil. The solid coating powder was constituted of ethylcellulose and pectin in weight ratios of 11:0 to 2:9. Its weight ratio to spheroids was varied between 2:3 and 3:2. Delayed 5-fluorouracil release was obtained when the weight ratio of ethylcellulose and pectin in coating powder was kept at 8:3, and weight ratio of solid coating powder to spheroids was kept at 3:2 with particle size of ethylcellulose reduced to 22 μm. Institute of Graduate Studies, UiTM 2014 Book Section PeerReviewed text en https://ir.uitm.edu.my/id/eprint/19620/1/ABS_ASSAD%20ALI%20FARAJ%20ELYAGOBY%20TDRA%20VOL%206%20IGS_14.pdf Colon-specific delivery of 5-fluorouracil from zinc pectinate spheroids through in situ intra-capsular ethylcellulose- pectin plug formation / Assad Ali Faraj Elyagoby. (2014) In: The Doctoral Research Abstracts. IPSis Biannual Publication, 6 (6). Institute of Graduate Studies, UiTM, Shah Alam. |
| spellingShingle | Malaysia Elyagoby, Assad Ali Faraj Colon-specific delivery of 5-fluorouracil from zinc pectinate spheroids through in situ intra-capsular ethylcellulose- pectin plug formation / Assad Ali Faraj Elyagoby |
| title | Colon-specific delivery of 5-fluorouracil from zinc pectinate spheroids through in situ intra-capsular ethylcellulose- pectin plug formation / Assad Ali Faraj Elyagoby |
| title_full | Colon-specific delivery of 5-fluorouracil from zinc pectinate spheroids through in situ intra-capsular ethylcellulose- pectin plug formation / Assad Ali Faraj Elyagoby |
| title_fullStr | Colon-specific delivery of 5-fluorouracil from zinc pectinate spheroids through in situ intra-capsular ethylcellulose- pectin plug formation / Assad Ali Faraj Elyagoby |
| title_full_unstemmed | Colon-specific delivery of 5-fluorouracil from zinc pectinate spheroids through in situ intra-capsular ethylcellulose- pectin plug formation / Assad Ali Faraj Elyagoby |
| title_short | Colon-specific delivery of 5-fluorouracil from zinc pectinate spheroids through in situ intra-capsular ethylcellulose- pectin plug formation / Assad Ali Faraj Elyagoby |
| title_sort | colon specific delivery of 5 fluorouracil from zinc pectinate spheroids through in situ intra capsular ethylcellulose pectin plug formation assad ali faraj elyagoby |
| topic | Malaysia |
| url | https://ir.uitm.edu.my/id/eprint/19620/1/ABS_ASSAD%20ALI%20FARAJ%20ELYAGOBY%20TDRA%20VOL%206%20IGS_14.pdf |
| work_keys_str_mv | AT elyagobyassadalifaraj colonspecificdeliveryof5fluorouracilfromzincpectinatespheroidsthroughinsituintracapsularethylcellulosepectinplugformationassadalifarajelyagoby |