Ficus deltoidea leaves extracts - promising therapeutic agent for oral candidiasis and denture stomatitis / Vivi Noryati Ahmad … [ et al.]
The aims of this study are to investigate antimicrobial and antibiofilm activities of Ficus deltoidea (F. deltoidea) leaves extract against Candida albicans (C. albicans). Methods: The antifungal activity was evaluated using minimum inhibitory concentration (MIC) and minimum fungicidal concentration...
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| Format: | Conference or Workshop Item |
| Language: | English |
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2019
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| Online Access: | https://ir.uitm.edu.my/id/eprint/30161/1/K_VIVI%20NORYATI%20AHMAD%20DSSS%20B%2019.pdf |
| _version_ | 1825737133875265536 |
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| author | Ahmad, Vivi Noryati Muhammad Zain, Nurhayati Mohd Amin, Indah Zulzaidi, Fazleen Ahmad Jafri, Mimi Syafiqa |
| author_facet | Ahmad, Vivi Noryati Muhammad Zain, Nurhayati Mohd Amin, Indah Zulzaidi, Fazleen Ahmad Jafri, Mimi Syafiqa |
| author_sort | Ahmad, Vivi Noryati |
| collection | UITM |
| description | The aims of this study are to investigate antimicrobial and antibiofilm activities of Ficus deltoidea (F. deltoidea) leaves extract against Candida albicans (C. albicans). Methods: The antifungal activity was evaluated using minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC). The potential of F. deltoidea leaves extract as antibiofilm agent was evaluated using biofilm inhibition assay and biofilm eradication assay. Chlorhexidine 0.12% (CHX) was used as a positive control. Each experiment was performed in triplicate and repeated four times independently. All the data obtained were analysed using SPSS version 23. Statistical significance measured using Kruskal Wallis test and post-hoc Mann Whitney test which presented as means ±SD with P value <0.001. Results: F. deltoidea extract showed antifungal activity against C. albicans with MIC and MFC, 50mg/ml and 100mg/ml respectively. The extract exhibited inhibitory effect on candida biofilm formation (69.5%). The preformed biofilm was significantly dispersed by extract upon 5 minutes treatment with eradication percentages 66.63%. The biofilm inhibition and biofilm eradication percentages for positive control CHX 0.12% were 43.0% and 58.97% respectively. Conclusion: Results of this study suggest the potential of F. deltoidea leaves extract as preventative and therapeutic agents against candida biofilm-related infections such as oral andidiasis and denture stomatitis. |
| first_indexed | 2024-03-06T02:13:26Z |
| format | Conference or Workshop Item |
| id | oai:ir.uitm.edu.my:30161 |
| institution | Universiti Teknologi MARA |
| language | English |
| last_indexed | 2024-03-06T02:13:26Z |
| publishDate | 2019 |
| record_format | dspace |
| spelling | oai:ir.uitm.edu.my:301612020-04-23T03:18:50Z https://ir.uitm.edu.my/id/eprint/30161/ Ficus deltoidea leaves extracts - promising therapeutic agent for oral candidiasis and denture stomatitis / Vivi Noryati Ahmad … [ et al.] Ahmad, Vivi Noryati Muhammad Zain, Nurhayati Mohd Amin, Indah Zulzaidi, Fazleen Ahmad Jafri, Mimi Syafiqa Oral and dental medicine. Pathology. Diseases The aims of this study are to investigate antimicrobial and antibiofilm activities of Ficus deltoidea (F. deltoidea) leaves extract against Candida albicans (C. albicans). Methods: The antifungal activity was evaluated using minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC). The potential of F. deltoidea leaves extract as antibiofilm agent was evaluated using biofilm inhibition assay and biofilm eradication assay. Chlorhexidine 0.12% (CHX) was used as a positive control. Each experiment was performed in triplicate and repeated four times independently. All the data obtained were analysed using SPSS version 23. Statistical significance measured using Kruskal Wallis test and post-hoc Mann Whitney test which presented as means ±SD with P value <0.001. Results: F. deltoidea extract showed antifungal activity against C. albicans with MIC and MFC, 50mg/ml and 100mg/ml respectively. The extract exhibited inhibitory effect on candida biofilm formation (69.5%). The preformed biofilm was significantly dispersed by extract upon 5 minutes treatment with eradication percentages 66.63%. The biofilm inhibition and biofilm eradication percentages for positive control CHX 0.12% were 43.0% and 58.97% respectively. Conclusion: Results of this study suggest the potential of F. deltoidea leaves extract as preventative and therapeutic agents against candida biofilm-related infections such as oral andidiasis and denture stomatitis. 2019 Conference or Workshop Item PeerReviewed text en https://ir.uitm.edu.my/id/eprint/30161/1/K_VIVI%20NORYATI%20AHMAD%20DSSS%20B%2019.pdf Ficus deltoidea leaves extracts - promising therapeutic agent for oral candidiasis and denture stomatitis / Vivi Noryati Ahmad … [ et al.]. (2019) In: Proceedings of 9th Dental Student’s Scientific Symposium,Malaysia (Malaysia, 2019), 9th – 10th April 2019, Faculty Dentistry, Universiti Teknologi MARA. https://dentistry.uitm.edu.my/v2/images/images/DSS/proceeding/vol1/pdf/10.pdf? |
| spellingShingle | Oral and dental medicine. Pathology. Diseases Ahmad, Vivi Noryati Muhammad Zain, Nurhayati Mohd Amin, Indah Zulzaidi, Fazleen Ahmad Jafri, Mimi Syafiqa Ficus deltoidea leaves extracts - promising therapeutic agent for oral candidiasis and denture stomatitis / Vivi Noryati Ahmad … [ et al.] |
| title | Ficus deltoidea leaves extracts - promising therapeutic agent for oral candidiasis and denture stomatitis / Vivi Noryati Ahmad … [ et al.] |
| title_full | Ficus deltoidea leaves extracts - promising therapeutic agent for oral candidiasis and denture stomatitis / Vivi Noryati Ahmad … [ et al.] |
| title_fullStr | Ficus deltoidea leaves extracts - promising therapeutic agent for oral candidiasis and denture stomatitis / Vivi Noryati Ahmad … [ et al.] |
| title_full_unstemmed | Ficus deltoidea leaves extracts - promising therapeutic agent for oral candidiasis and denture stomatitis / Vivi Noryati Ahmad … [ et al.] |
| title_short | Ficus deltoidea leaves extracts - promising therapeutic agent for oral candidiasis and denture stomatitis / Vivi Noryati Ahmad … [ et al.] |
| title_sort | ficus deltoidea leaves extracts promising therapeutic agent for oral candidiasis and denture stomatitis vivi noryati ahmad et al |
| topic | Oral and dental medicine. Pathology. Diseases |
| url | https://ir.uitm.edu.my/id/eprint/30161/1/K_VIVI%20NORYATI%20AHMAD%20DSSS%20B%2019.pdf |
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