Effects of microwave on drug release responses of spray-dried alginate microspheres / Ekha Mardziah Radman
The behavior of rigid guluronic acid-rich (MG) and flexible mannuronic acid-rich (MC) alginate in controlling drug release responses of spray-dried microspheres against microwave was investigated using sodium diclofenac as model water-soluble drug. MC microspheres required a shorter period of micro...
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| Format: | Thesis |
| Language: | English |
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2010
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| Online Access: | https://ir.uitm.edu.my/id/eprint/4833/1/TM_EKHA%20MARDZIAH%20RADMAN%20PH%2010_5.pdf |
| _version_ | 1796899492605198336 |
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| author | Radman, Ekha Mardziah |
| author_facet | Radman, Ekha Mardziah |
| author_sort | Radman, Ekha Mardziah |
| collection | UITM |
| description | The behavior of rigid guluronic acid-rich (MG) and flexible mannuronic acid-rich (MC) alginate in controlling drug release responses of spray-dried microspheres against
microwave was investigated using sodium diclofenac as model water-soluble drug. MC microspheres required a shorter period of microwave irradiation to reduce drug release
extent than MG microspheres. In response to microwave, the drug release profiles of 1:1 MG-MG microspheres resembled MC microspheres. The state of polymer-polymer and drug-polymer interaction via 0-H and/or N-H moiety of microspheres was affected by alginate chain flexibility under the influence of microwave. It then governed the drug
release responses of microspheres. |
| first_indexed | 2024-03-06T01:21:50Z |
| format | Thesis |
| id | oai:ir.uitm.edu.my:4833 |
| institution | Universiti Teknologi MARA |
| language | English |
| last_indexed | 2024-03-06T01:21:50Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oai:ir.uitm.edu.my:48332018-08-30T04:30:37Z https://ir.uitm.edu.my/id/eprint/4833/ Effects of microwave on drug release responses of spray-dried alginate microspheres / Ekha Mardziah Radman Radman, Ekha Mardziah RS Pharmacy and materia medica The behavior of rigid guluronic acid-rich (MG) and flexible mannuronic acid-rich (MC) alginate in controlling drug release responses of spray-dried microspheres against microwave was investigated using sodium diclofenac as model water-soluble drug. MC microspheres required a shorter period of microwave irradiation to reduce drug release extent than MG microspheres. In response to microwave, the drug release profiles of 1:1 MG-MG microspheres resembled MC microspheres. The state of polymer-polymer and drug-polymer interaction via 0-H and/or N-H moiety of microspheres was affected by alginate chain flexibility under the influence of microwave. It then governed the drug release responses of microspheres. 2010 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/4833/1/TM_EKHA%20MARDZIAH%20RADMAN%20PH%2010_5.pdf Effects of microwave on drug release responses of spray-dried alginate microspheres / Ekha Mardziah Radman. (2010) Masters thesis, thesis, Universiti Teknologi MARA. |
| spellingShingle | RS Pharmacy and materia medica Radman, Ekha Mardziah Effects of microwave on drug release responses of spray-dried alginate microspheres / Ekha Mardziah Radman |
| title | Effects of microwave on drug release responses of spray-dried alginate microspheres / Ekha Mardziah Radman |
| title_full | Effects of microwave on drug release responses of spray-dried alginate microspheres / Ekha Mardziah Radman |
| title_fullStr | Effects of microwave on drug release responses of spray-dried alginate microspheres / Ekha Mardziah Radman |
| title_full_unstemmed | Effects of microwave on drug release responses of spray-dried alginate microspheres / Ekha Mardziah Radman |
| title_short | Effects of microwave on drug release responses of spray-dried alginate microspheres / Ekha Mardziah Radman |
| title_sort | effects of microwave on drug release responses of spray dried alginate microspheres ekha mardziah radman |
| topic | RS Pharmacy and materia medica |
| url | https://ir.uitm.edu.my/id/eprint/4833/1/TM_EKHA%20MARDZIAH%20RADMAN%20PH%2010_5.pdf |
| work_keys_str_mv | AT radmanekhamardziah effectsofmicrowaveondrugreleaseresponsesofspraydriedalginatemicrospheresekhamardziahradman |