Inhibition of microvesiculation sensitizes prostate cancer cells to chemotherapy and reduces docetaxel dose required to limit tumor growth in vivo

Microvesicles shed from cells carry constituents of the cell cytoplasm, including, of importance in multidrug resistance to cancer chemotherapy, drugs that the tumor cell attempts to efflux. To see whether such drugs could be used at lower concentrations with the same efficacy, it was first shown th...

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Bibliographic Details
Main Authors: Jorfi, Samireh, Ansa-Addo, Ephraim A., Kholia, Sharadkumar Rajnikant, Stratton, Dan, Valley, Shaunelle, Lange, Sigrun, Inal, Jameel
Format: Article
Language:English
Published: Nature Group Publishing 2015
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Online Access:https://repository.londonmet.ac.uk/1000/1/Sci%20Rep%202015.pdf