A novel role for peptidylarginine deiminases in microvesicle release reveals therapeutic potential of PAD inhibition in sensitizing prostate cancer cells to chemotherapy

A novel role for peptidylarginine deiminases in microvesicle release reveals therapeutic potential of PAD inhibition in sensitizing prostate cancer cells to chemotherapy

INTRODUCTION: Protein deimination, defined as the post-translational conversion of protein-bound arginine to citrulline, is carried out by a family of 5 calcium-dependent enzymes, the peptidylarginine deiminases (PADs) and has been linked to various cancers. Cellular microvesicle (MV) release, whic...

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Bibliographic Details
Main Authors: Kholia, Sharadkumar Rajnikant, Jorfi, Samireh, Thompson, Paul R., Causey, Corey P., Nicholas, Anthony P., Inal, Jameel, Lange, Sigrun
Format: Article
Language:English
Published: Co-Action Publishing 2015
Subjects:
610 Medicine & health
Online Access:https://repository.londonmet.ac.uk/1001/1/JEV%20PAD%20paper%202015.pdf

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