Mpox virus (MPXV): comprehensive analysis of pandemic risks, pathophysiology, treatments, and mRNA vaccine development
Mpox, formerly known as monkeypox, is a zoonotic disease caused by the Mpox virus (MPXV), which has recently attracted global attention due to its potential for widespread outbreaks. Initially identified in 1958, MPXV primarily spreads to humans through contact with infected wild animals, particular...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Springer-Verlag GmbH Germany, part of Springer Nature
2025
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| Online Access: | https://repository.londonmet.ac.uk/10019/7/Clean%20Version%20of%20mPOX%20manuscript%20.pdf |
| _version_ | 1824446523396587520 |
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| author | Eslamkhah, Sajjad Aslan, Elif Sibel Yavas, Cuneyd Akcali, Nermin Batur, Lutfiye Karcioglu Abuaisha, Asmaa Yildirim, Erva Esma Solak, Mustafa White, Kenneth |
| author_facet | Eslamkhah, Sajjad Aslan, Elif Sibel Yavas, Cuneyd Akcali, Nermin Batur, Lutfiye Karcioglu Abuaisha, Asmaa Yildirim, Erva Esma Solak, Mustafa White, Kenneth |
| author_sort | Eslamkhah, Sajjad |
| collection | LMU |
| description | Mpox, formerly known as monkeypox, is a zoonotic disease caused by the Mpox virus (MPXV), which has recently attracted global attention due to its potential for widespread outbreaks. Initially identified in 1958, MPXV primarily spreads to humans through contact with infected wild animals, particularly rodents. Historically confined to Africa, the virus has expanded beyond endemic regions, with notable outbreaks in Europe and North America in 2022, especially among men who have sex with men (MSM). The World Health Organization (WHO) has declared the current Mpox outbreak a Public Health Emergency of International Concern. This review explores the epidemiology, pathophysiology, and clinical manifestations of MPXV, along with current treatment strategies and the role of mRNA vaccines. It emphasizes the importance of understanding the changing dynamics of Mpox transmission, which are influenced by factors such as waning immunity from smallpox vaccinations and increased global interconnectedness. The potential for developing multi-epitope vaccines that can stimulate robust immune responses is highlighted, showcasing how bioinformatics can facilitate the identification of immunogenic antigens. Continued research and investment in vaccine development are crucial to address the urgent need for effective candidates that can protect at-risk populations. In summary, this review underscores the necessity for proactive public health measures and collaborative efforts among healthcare authorities, researchers, and communities to mitigate the impact of Mpox and enhance global preparedness for future outbreaks. |
| first_indexed | 2025-02-19T01:16:31Z |
| format | Article |
| id | oai:repository.londonmet.ac.uk:10019 |
| institution | London Metropolitan University |
| language | English |
| last_indexed | 2025-02-19T01:16:31Z |
| publishDate | 2025 |
| publisher | Springer-Verlag GmbH Germany, part of Springer Nature |
| record_format | eprints |
| spelling | oai:repository.londonmet.ac.uk:100192025-01-13T11:22:57Z https://repository.londonmet.ac.uk/10019/ Mpox virus (MPXV): comprehensive analysis of pandemic risks, pathophysiology, treatments, and mRNA vaccine development Eslamkhah, Sajjad Aslan, Elif Sibel Yavas, Cuneyd Akcali, Nermin Batur, Lutfiye Karcioglu Abuaisha, Asmaa Yildirim, Erva Esma Solak, Mustafa White, Kenneth 570 Life sciences; biology 610 Medicine & health Mpox, formerly known as monkeypox, is a zoonotic disease caused by the Mpox virus (MPXV), which has recently attracted global attention due to its potential for widespread outbreaks. Initially identified in 1958, MPXV primarily spreads to humans through contact with infected wild animals, particularly rodents. Historically confined to Africa, the virus has expanded beyond endemic regions, with notable outbreaks in Europe and North America in 2022, especially among men who have sex with men (MSM). The World Health Organization (WHO) has declared the current Mpox outbreak a Public Health Emergency of International Concern. This review explores the epidemiology, pathophysiology, and clinical manifestations of MPXV, along with current treatment strategies and the role of mRNA vaccines. It emphasizes the importance of understanding the changing dynamics of Mpox transmission, which are influenced by factors such as waning immunity from smallpox vaccinations and increased global interconnectedness. The potential for developing multi-epitope vaccines that can stimulate robust immune responses is highlighted, showcasing how bioinformatics can facilitate the identification of immunogenic antigens. Continued research and investment in vaccine development are crucial to address the urgent need for effective candidates that can protect at-risk populations. In summary, this review underscores the necessity for proactive public health measures and collaborative efforts among healthcare authorities, researchers, and communities to mitigate the impact of Mpox and enhance global preparedness for future outbreaks. Springer-Verlag GmbH Germany, part of Springer Nature 2025-01-08 Article PeerReviewed text en https://repository.londonmet.ac.uk/10019/7/Clean%20Version%20of%20mPOX%20manuscript%20.pdf Eslamkhah, Sajjad, Aslan, Elif Sibel, Yavas, Cuneyd, Akcali, Nermin, Batur, Lutfiye Karcioglu, Abuaisha, Asmaa, Yildirim, Erva Esma, Solak, Mustafa and White, Kenneth (2025) Mpox virus (MPXV): comprehensive analysis of pandemic risks, pathophysiology, treatments, and mRNA vaccine development. Naunyn-Schmiedeberg's Archives of Pharmacology. ISSN 0028-1298 https://doi.org/10.1007/s00210-024-03649-9 10.1007/s00210-024-03649-9 10.1007/s00210-024-03649-9 |
| spellingShingle | 570 Life sciences; biology 610 Medicine & health Eslamkhah, Sajjad Aslan, Elif Sibel Yavas, Cuneyd Akcali, Nermin Batur, Lutfiye Karcioglu Abuaisha, Asmaa Yildirim, Erva Esma Solak, Mustafa White, Kenneth Mpox virus (MPXV): comprehensive analysis of pandemic risks, pathophysiology, treatments, and mRNA vaccine development |
| title | Mpox virus (MPXV): comprehensive analysis of pandemic risks, pathophysiology, treatments, and mRNA vaccine development |
| title_full | Mpox virus (MPXV): comprehensive analysis of pandemic risks, pathophysiology, treatments, and mRNA vaccine development |
| title_fullStr | Mpox virus (MPXV): comprehensive analysis of pandemic risks, pathophysiology, treatments, and mRNA vaccine development |
| title_full_unstemmed | Mpox virus (MPXV): comprehensive analysis of pandemic risks, pathophysiology, treatments, and mRNA vaccine development |
| title_short | Mpox virus (MPXV): comprehensive analysis of pandemic risks, pathophysiology, treatments, and mRNA vaccine development |
| title_sort | mpox virus mpxv comprehensive analysis of pandemic risks pathophysiology treatments and mrna vaccine development |
| topic | 570 Life sciences; biology 610 Medicine & health |
| url | https://repository.londonmet.ac.uk/10019/7/Clean%20Version%20of%20mPOX%20manuscript%20.pdf |
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