A novel role for peptidylarginine deiminases in microvesicle release reveals therapeutic potential of PAD inhibition in sensitizing prostate cancer cells to chemotherapy
INTRODUCTION: Protein deimination, defined as the post-translational conversion of protein-bound arginine to citrulline, is carried out by a family of 5 calcium-dependent enzymes, the peptidylarginine deiminases (PADs) and has been linked to various cancers. Cellular microvesicle (MV) release, whic...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Co-Action Publishing
2015
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| Subjects: | |
| Online Access: | https://repository.londonmet.ac.uk/1001/1/JEV%20PAD%20paper%202015.pdf |