Structural lipid nanoparticles self-assembled from electrospun core-shell polymeric nanocomposites

Electrospun polymeric core–shell nanocomposites are exploited as templates to manipulate molecular self-assembly for preparing structural lipid nanoparticles, during which the confinement effect of fibers together with their core–shell structure, the aqueous environment and the secondary interaction...

Full description

Bibliographic Details
Main Authors: Yu, Deng-Guang, White, Kenneth, Chatterton, Nicholas, Li, Ying, Li, Lingling, Wang, Xia
Format: Article
Language:English
Published: Royal Society of Chemistry 2015
Subjects:
Online Access:https://repository.londonmet.ac.uk/1034/1/RSC%20Adv%20v5%20p9462%202015%20%5BKW057%5D.pdf
Description
Summary:Electrospun polymeric core–shell nanocomposites are exploited as templates to manipulate molecular self-assembly for preparing structural lipid nanoparticles, during which the confinement effect of fibers together with their core–shell structure, the aqueous environment and the secondary interactions, all contributed synergistically to facilitate molecular self-aggregation to produce lipid nanoparticles with a drug entrapment efficiency of 95.9% with a sustained drug release profile.