Tuneable radical cyclisations: a tin-free approach towards tricyclic and spirocyclic heterocycles via a common precursor

A novel common precursor approach towards both tricyclic and spirocyclic heterocycles is described. Cyclisations are based on thiyl radical/isocyanide methodology and avoid the use of tin.

Detalhes bibliográficos
Main Authors: Patel, Bhaven, Saviolaki, G., Ayats, C., Garcia, M. A. E., Kapadia, T., Hilton, Stephen T.
Formato: Artigo
Idioma:English
Publicado em: 2014
Assuntos:
Acesso em linha:https://repository.londonmet.ac.uk/1042/1/c4ra02420f.pdf
Descrição
Resumo:A novel common precursor approach towards both tricyclic and spirocyclic heterocycles is described. Cyclisations are based on thiyl radical/isocyanide methodology and avoid the use of tin.