3D‐printed polypropylene continuous‐flow column reactors: exploration of reactor utility in SNAr reactions and the synthesis of bicyclic and tetracyclic heterocycles
3D printing has the potential to transform the way in which chemical reactions are carried out due to its low‐cost, ease‐of‐use as a technology and its capacity to expedite the development of iteratively enhanced prototypes. In this present study, we developed a novel, low‐cost polypropylene (PP) co...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley-Blackwell
2017
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| Subjects: | |
| Online Access: | https://repository.londonmet.ac.uk/1405/1/Hilton%20Manuscript%20Accepted%20article.pdf |
| _version_ | 1825624776271462400 |
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| author | Rao, Zenobia X. Patel, Bhaven Monaco, Alessandra Cao, Zi Jing Barniol-Xicota, Marta Pichon, Enora Ladlow, Mark Hilton, Stephen T. |
| author_facet | Rao, Zenobia X. Patel, Bhaven Monaco, Alessandra Cao, Zi Jing Barniol-Xicota, Marta Pichon, Enora Ladlow, Mark Hilton, Stephen T. |
| author_sort | Rao, Zenobia X. |
| collection | LMU |
| description | 3D printing has the potential to transform the way in which chemical reactions are carried out due to its low‐cost, ease‐of‐use as a technology and its capacity to expedite the development of iteratively enhanced prototypes. In this present study, we developed a novel, low‐cost polypropylene (PP) column reactor that was incorporated into an existing continuous‐flow reactor for the synthesis of heterocycles. The utility and solvent resistance of the printed devices were explored in SNAr reactions to produce substituted aniline derivatives and in the synthesis of bicyclic and tetracyclic heterocycles. Using this approach, a range of heterocyclic compounds was synthesised including the core structure of the natural product (±)‐γ‐lycorane and structurally complex compounds based on the tetracyclic core of the erythrina alkaloids. |
| first_indexed | 2024-07-09T03:46:58Z |
| format | Article |
| id | oai:repository.londonmet.ac.uk:1405 |
| institution | London Metropolitan University |
| language | English |
| last_indexed | 2024-07-09T03:46:58Z |
| publishDate | 2017 |
| publisher | Wiley-Blackwell |
| record_format | eprints |
| spelling | oai:repository.londonmet.ac.uk:14052022-10-21T09:15:00Z https://repository.londonmet.ac.uk/1405/ 3D‐printed polypropylene continuous‐flow column reactors: exploration of reactor utility in SNAr reactions and the synthesis of bicyclic and tetracyclic heterocycles Rao, Zenobia X. Patel, Bhaven Monaco, Alessandra Cao, Zi Jing Barniol-Xicota, Marta Pichon, Enora Ladlow, Mark Hilton, Stephen T. 540 Chemistry & allied sciences 3D printing has the potential to transform the way in which chemical reactions are carried out due to its low‐cost, ease‐of‐use as a technology and its capacity to expedite the development of iteratively enhanced prototypes. In this present study, we developed a novel, low‐cost polypropylene (PP) column reactor that was incorporated into an existing continuous‐flow reactor for the synthesis of heterocycles. The utility and solvent resistance of the printed devices were explored in SNAr reactions to produce substituted aniline derivatives and in the synthesis of bicyclic and tetracyclic heterocycles. Using this approach, a range of heterocyclic compounds was synthesised including the core structure of the natural product (±)‐γ‐lycorane and structurally complex compounds based on the tetracyclic core of the erythrina alkaloids. Wiley-Blackwell 2017-08-09 Article PeerReviewed text en https://repository.londonmet.ac.uk/1405/1/Hilton%20Manuscript%20Accepted%20article.pdf Rao, Zenobia X., Patel, Bhaven, Monaco, Alessandra, Cao, Zi Jing, Barniol-Xicota, Marta, Pichon, Enora, Ladlow, Mark and Hilton, Stephen T. (2017) 3D‐printed polypropylene continuous‐flow column reactors: exploration of reactor utility in SNAr reactions and the synthesis of bicyclic and tetracyclic heterocycles. European Journal of Organic Chemistry, 2017 (44). pp. 6499-6504. ISSN 1434-193X https://onlinelibrary.wiley.com/doi/abs/10.1002/ejoc.201701111 10.1002/ejoc.201701111 10.1002/ejoc.201701111 |
| spellingShingle | 540 Chemistry & allied sciences Rao, Zenobia X. Patel, Bhaven Monaco, Alessandra Cao, Zi Jing Barniol-Xicota, Marta Pichon, Enora Ladlow, Mark Hilton, Stephen T. 3D‐printed polypropylene continuous‐flow column reactors: exploration of reactor utility in SNAr reactions and the synthesis of bicyclic and tetracyclic heterocycles |
| title | 3D‐printed polypropylene continuous‐flow column reactors: exploration of reactor utility in SNAr reactions and the synthesis of bicyclic and tetracyclic heterocycles |
| title_full | 3D‐printed polypropylene continuous‐flow column reactors: exploration of reactor utility in SNAr reactions and the synthesis of bicyclic and tetracyclic heterocycles |
| title_fullStr | 3D‐printed polypropylene continuous‐flow column reactors: exploration of reactor utility in SNAr reactions and the synthesis of bicyclic and tetracyclic heterocycles |
| title_full_unstemmed | 3D‐printed polypropylene continuous‐flow column reactors: exploration of reactor utility in SNAr reactions and the synthesis of bicyclic and tetracyclic heterocycles |
| title_short | 3D‐printed polypropylene continuous‐flow column reactors: exploration of reactor utility in SNAr reactions and the synthesis of bicyclic and tetracyclic heterocycles |
| title_sort | 3d printed polypropylene continuous flow column reactors exploration of reactor utility in snar reactions and the synthesis of bicyclic and tetracyclic heterocycles |
| topic | 540 Chemistry & allied sciences |
| url | https://repository.londonmet.ac.uk/1405/1/Hilton%20Manuscript%20Accepted%20article.pdf |
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