The synthesis and pharmacological evaluation of quisqualic acid and some novel excitatory amino acid mimetics
L-Glutamic acid and L-aspartic acid are believed to be the principal initiators of excitatory synaptic neurotransmission in the mammalian central system. A number of molecules of either natural or synthetic origin have been identified as possessing agonist or antagonist properties at glutamate bindi...
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| Format: | Thesis |
| Language: | English |
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1992
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| Online Access: | https://repository.londonmet.ac.uk/2965/1/238892.pdf |
| _version_ | 1804072007262797824 |
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| author | Okonkwo, P. I. |
| author_facet | Okonkwo, P. I. |
| author_sort | Okonkwo, P. I. |
| collection | LMU |
| description | L-Glutamic acid and L-aspartic acid are believed to be the principal initiators of excitatory synaptic neurotransmission in the mammalian central system. A number of molecules of either natural or synthetic origin have been identified as possessing agonist or antagonist properties at glutamate binding sites. One of the most potent agonist is quisqualic acid (69), and this thesis features two aspects of the synthetic organic chemistry and the pharmacology of quisqualic acid and some of its analogues. |
| first_indexed | 2024-07-09T03:52:18Z |
| format | Thesis |
| id | oai:repository.londonmet.ac.uk:2965 |
| institution | London Metropolitan University |
| language | English |
| last_indexed | 2024-07-09T03:52:18Z |
| publishDate | 1992 |
| record_format | eprints |
| spelling | oai:repository.londonmet.ac.uk:29652018-08-29T15:33:18Z http://repository.londonmet.ac.uk/2965/ The synthesis and pharmacological evaluation of quisqualic acid and some novel excitatory amino acid mimetics Okonkwo, P. I. 500 Natural Sciences and Mathematics 540 Chemistry & allied sciences L-Glutamic acid and L-aspartic acid are believed to be the principal initiators of excitatory synaptic neurotransmission in the mammalian central system. A number of molecules of either natural or synthetic origin have been identified as possessing agonist or antagonist properties at glutamate binding sites. One of the most potent agonist is quisqualic acid (69), and this thesis features two aspects of the synthetic organic chemistry and the pharmacology of quisqualic acid and some of its analogues. 1992 Thesis NonPeerReviewed text en https://repository.londonmet.ac.uk/2965/1/238892.pdf Okonkwo, P. I. (1992) The synthesis and pharmacological evaluation of quisqualic acid and some novel excitatory amino acid mimetics. Doctoral thesis, London Guildhall University. |
| spellingShingle | 500 Natural Sciences and Mathematics 540 Chemistry & allied sciences Okonkwo, P. I. The synthesis and pharmacological evaluation of quisqualic acid and some novel excitatory amino acid mimetics |
| title | The synthesis and pharmacological evaluation of quisqualic acid and some novel excitatory amino acid mimetics |
| title_full | The synthesis and pharmacological evaluation of quisqualic acid and some novel excitatory amino acid mimetics |
| title_fullStr | The synthesis and pharmacological evaluation of quisqualic acid and some novel excitatory amino acid mimetics |
| title_full_unstemmed | The synthesis and pharmacological evaluation of quisqualic acid and some novel excitatory amino acid mimetics |
| title_short | The synthesis and pharmacological evaluation of quisqualic acid and some novel excitatory amino acid mimetics |
| title_sort | synthesis and pharmacological evaluation of quisqualic acid and some novel excitatory amino acid mimetics |
| topic | 500 Natural Sciences and Mathematics 540 Chemistry & allied sciences |
| url | https://repository.londonmet.ac.uk/2965/1/238892.pdf |
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