Cannabidiol (CBD) is a novel inhibitor for Exosome and Microvesicle (EMV) release in cancer
Exosomes and microvesicles (EMV) are lipid bilayer-enclosed structures, released by cells and involved in intercellular communication through transfer of proteins and genetic material. EMV release is also associated with various pathologies, including cancer, where increased EMV release is amongst o...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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2018
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| Online Access: | https://repository.londonmet.ac.uk/3046/1/fphar-09-00889.pdf |
| _version_ | 1804072030254923776 |
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| author | Kosgodage, Uchini S. Mould, Rhys Henley, Aine B. Nunn, Alistair V. Guy, Geoffrey W. Thomas, E. Louise Inal, Jameel Bell, Jimmy D. Lange, Sigrun |
| author_facet | Kosgodage, Uchini S. Mould, Rhys Henley, Aine B. Nunn, Alistair V. Guy, Geoffrey W. Thomas, E. Louise Inal, Jameel Bell, Jimmy D. Lange, Sigrun |
| author_sort | Kosgodage, Uchini S. |
| collection | LMU |
| description | Exosomes and microvesicles (EMV) are lipid bilayer-enclosed structures, released by cells and involved in intercellular communication through transfer of proteins and genetic material. EMV release is also associated with various pathologies, including cancer, where increased EMV release is amongst other associated with chemo-resistance and active transfer of pro-oncogenic factors. Recent studies show that EMV-inhibiting agents can sensitize cancer cells to chemotherapeutic agents and reduce cancer growth . Cannabidiol (CBD), a phytocannabinoid derived from , has anti-inflammatory and anti-oxidant properties, and displays anti-proliferative activity. Here we report a novel role for CBD as a potent inhibitor of EMV release from three cancer cell lines: prostate cancer (PC3), hepatocellular carcinoma (HEPG2) and breast adenocarcinoma (MDA-MB-231). CBD significantly reduced exosome release in all three cancer cell lines, and also significantly, albeit more variably, inhibited microvesicle release. The EMV modulating effects of CBD were found to be dose dependent (1 and 5 μM) and cancer cell type specific. Moreover, we provide evidence that this may be associated with changes in mitochondrial function, including modulation of STAT3 and prohibitin expression, and that CBD can be used to sensitize cancer cells to chemotherapy. We suggest that the known anti-cancer effects of CBD may partly be due to the regulatory effects on EMV biogenesis, and thus CBD poses as a novel and safe modulator of EMV-mediated pathological events. |
| first_indexed | 2024-07-09T03:52:40Z |
| format | Article |
| id | oai:repository.londonmet.ac.uk:3046 |
| institution | London Metropolitan University |
| language | English |
| last_indexed | 2024-07-09T03:52:40Z |
| publishDate | 2018 |
| record_format | eprints |
| spelling | oai:repository.londonmet.ac.uk:30462020-12-08T14:40:06Z http://repository.londonmet.ac.uk/3046/ Cannabidiol (CBD) is a novel inhibitor for Exosome and Microvesicle (EMV) release in cancer Kosgodage, Uchini S. Mould, Rhys Henley, Aine B. Nunn, Alistair V. Guy, Geoffrey W. Thomas, E. Louise Inal, Jameel Bell, Jimmy D. Lange, Sigrun 610 Medicine & health Exosomes and microvesicles (EMV) are lipid bilayer-enclosed structures, released by cells and involved in intercellular communication through transfer of proteins and genetic material. EMV release is also associated with various pathologies, including cancer, where increased EMV release is amongst other associated with chemo-resistance and active transfer of pro-oncogenic factors. Recent studies show that EMV-inhibiting agents can sensitize cancer cells to chemotherapeutic agents and reduce cancer growth . Cannabidiol (CBD), a phytocannabinoid derived from , has anti-inflammatory and anti-oxidant properties, and displays anti-proliferative activity. Here we report a novel role for CBD as a potent inhibitor of EMV release from three cancer cell lines: prostate cancer (PC3), hepatocellular carcinoma (HEPG2) and breast adenocarcinoma (MDA-MB-231). CBD significantly reduced exosome release in all three cancer cell lines, and also significantly, albeit more variably, inhibited microvesicle release. The EMV modulating effects of CBD were found to be dose dependent (1 and 5 μM) and cancer cell type specific. Moreover, we provide evidence that this may be associated with changes in mitochondrial function, including modulation of STAT3 and prohibitin expression, and that CBD can be used to sensitize cancer cells to chemotherapy. We suggest that the known anti-cancer effects of CBD may partly be due to the regulatory effects on EMV biogenesis, and thus CBD poses as a novel and safe modulator of EMV-mediated pathological events. 2018-08-13 Article PeerReviewed text en https://repository.londonmet.ac.uk/3046/1/fphar-09-00889.pdf Kosgodage, Uchini S., Mould, Rhys, Henley, Aine B., Nunn, Alistair V., Guy, Geoffrey W., Thomas, E. Louise, Inal, Jameel, Bell, Jimmy D. and Lange, Sigrun (2018) Cannabidiol (CBD) is a novel inhibitor for Exosome and Microvesicle (EMV) release in cancer. Frontiers in pharmacology, 9. p. 889. ISSN 1663-9812 10.3389/fphar.2018.00889 |
| spellingShingle | 610 Medicine & health Kosgodage, Uchini S. Mould, Rhys Henley, Aine B. Nunn, Alistair V. Guy, Geoffrey W. Thomas, E. Louise Inal, Jameel Bell, Jimmy D. Lange, Sigrun Cannabidiol (CBD) is a novel inhibitor for Exosome and Microvesicle (EMV) release in cancer |
| title | Cannabidiol (CBD) is a novel inhibitor for Exosome and Microvesicle (EMV) release in cancer |
| title_full | Cannabidiol (CBD) is a novel inhibitor for Exosome and Microvesicle (EMV) release in cancer |
| title_fullStr | Cannabidiol (CBD) is a novel inhibitor for Exosome and Microvesicle (EMV) release in cancer |
| title_full_unstemmed | Cannabidiol (CBD) is a novel inhibitor for Exosome and Microvesicle (EMV) release in cancer |
| title_short | Cannabidiol (CBD) is a novel inhibitor for Exosome and Microvesicle (EMV) release in cancer |
| title_sort | cannabidiol cbd is a novel inhibitor for exosome and microvesicle emv release in cancer |
| topic | 610 Medicine & health |
| url | https://repository.londonmet.ac.uk/3046/1/fphar-09-00889.pdf |
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