Nicotinamide Nucleotide Transhydrogenase as a novel treatment target in adrenocortical carcinoma

Nicotinamide Nucleotide Transhydrogenase as a novel treatment target in adrenocortical carcinoma

Adrenocortical carcinoma (ACC) is an aggressive malignancy with poor response to chemotherapy. In this study, we evaluated a potential new treatment target for ACC, focusing on the mitochondrial reduced form of NAD phosphate (NADPH) generator nicotinamide nucleotide transhydrogenase (NNT). NNT has a...

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Bibliographic Details
Main Authors:	Chortis, Vasileios, Taylor, Angela E., Doig, Craig L., Walsh, Mark D., Meimaridou, Eirini, Jenkinson, Carl, Rodriguez-Blanco, Giovanny, Ronchi, Cristina L., Jafri, Alisha, Metherell, Louise A., Hebenstreit, Daniel, Dunn, Warwick B., Arlt, Wiebke, Foster, Paul A.
Format:	Article
Language:	English English English
Published:	Oxford University Press 2018
Subjects:	570 Life sciences; biology 610 Medicine & health
Online Access:	https://repository.londonmet.ac.uk/4979/13/NNT_Manuscript_April2018.pdf https://repository.londonmet.ac.uk/4979/14/NNT_paper_figures_April2018.pdf https://repository.londonmet.ac.uk/4979/5/NNT_Supplementary_File_April2018.pdf

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