Roles and mechanisms of renalase in cardiovascular disease: a promising therapeutic target
Cardiovascular disease (CVD) is prevalent worldwide and remains a leading cause of death. Although substantial progress has been made in the diagnosis and treatment of CVD, the prognosis remains unsatisfactory. Renalase is a newly discovered cytokine that is synthesized by the kidney and then secret...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020
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| Online Access: | https://repository.londonmet.ac.uk/6067/1/1-s2.0-S0753332220309057-main.pdf |
| _version_ | 1804072561218158592 |
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| author | Li, Yue Wu, Weidong Liu, Weihong Zhou, Mingxue |
| author_facet | Li, Yue Wu, Weidong Liu, Weihong Zhou, Mingxue |
| author_sort | Li, Yue |
| collection | LMU |
| description | Cardiovascular disease (CVD) is prevalent worldwide and remains a leading cause of death. Although substantial progress has been made in the diagnosis and treatment of CVD, the prognosis remains unsatisfactory. Renalase is a newly discovered cytokine that is synthesized by the kidney and then secreted into blood. Numerous studies have suggested the efficacy of renalase in treating CVD by metabolizing catecholamines in the circulatory system. As a new biomarker of heart disease, renalase is normally recognized as a signalling molecule that activates cytoprotective intracellular signals to lower blood pressure, protect ischaemic heart muscle and promote atherosclerotic plaque stability in CVD, which subsequently improves cardiac function. Due to its important regulatory role in the circulatory system, renalase has gradually become a potential target in the treatment of CVD. This review summarizes the structure, mechanism and function of renalase in CVD, thereby providing preclinical evidence for alternative approaches and new prospects in the development of renalase-related drugs against CVD. [Abstract copyright: Copyright © 2020 The Author(s). Published by Elsevier Masson SAS.. All rights reserved.] |
| first_indexed | 2024-07-09T04:01:06Z |
| format | Article |
| id | oai:repository.londonmet.ac.uk:6067 |
| institution | London Metropolitan University |
| language | English |
| last_indexed | 2024-07-09T04:01:06Z |
| publishDate | 2020 |
| publisher | Elsevier |
| record_format | eprints |
| spelling | oai:repository.londonmet.ac.uk:60672020-10-09T11:14:43Z http://repository.londonmet.ac.uk/6067/ Roles and mechanisms of renalase in cardiovascular disease: a promising therapeutic target Li, Yue Wu, Weidong Liu, Weihong Zhou, Mingxue 610 Medicine & health Cardiovascular disease (CVD) is prevalent worldwide and remains a leading cause of death. Although substantial progress has been made in the diagnosis and treatment of CVD, the prognosis remains unsatisfactory. Renalase is a newly discovered cytokine that is synthesized by the kidney and then secreted into blood. Numerous studies have suggested the efficacy of renalase in treating CVD by metabolizing catecholamines in the circulatory system. As a new biomarker of heart disease, renalase is normally recognized as a signalling molecule that activates cytoprotective intracellular signals to lower blood pressure, protect ischaemic heart muscle and promote atherosclerotic plaque stability in CVD, which subsequently improves cardiac function. Due to its important regulatory role in the circulatory system, renalase has gradually become a potential target in the treatment of CVD. This review summarizes the structure, mechanism and function of renalase in CVD, thereby providing preclinical evidence for alternative approaches and new prospects in the development of renalase-related drugs against CVD. [Abstract copyright: Copyright © 2020 The Author(s). Published by Elsevier Masson SAS.. All rights reserved.] Elsevier 2020-09-09 Article PeerReviewed text en https://repository.londonmet.ac.uk/6067/1/1-s2.0-S0753332220309057-main.pdf Li, Yue, Wu, Weidong, Liu, Weihong and Zhou, Mingxue (2020) Roles and mechanisms of renalase in cardiovascular disease: a promising therapeutic target. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 131 (110712). ISSN 1950-6007 10.1016/j.biopha.2020.110712 |
| spellingShingle | 610 Medicine & health Li, Yue Wu, Weidong Liu, Weihong Zhou, Mingxue Roles and mechanisms of renalase in cardiovascular disease: a promising therapeutic target |
| title | Roles and mechanisms of renalase in cardiovascular disease: a promising therapeutic target |
| title_full | Roles and mechanisms of renalase in cardiovascular disease: a promising therapeutic target |
| title_fullStr | Roles and mechanisms of renalase in cardiovascular disease: a promising therapeutic target |
| title_full_unstemmed | Roles and mechanisms of renalase in cardiovascular disease: a promising therapeutic target |
| title_short | Roles and mechanisms of renalase in cardiovascular disease: a promising therapeutic target |
| title_sort | roles and mechanisms of renalase in cardiovascular disease a promising therapeutic target |
| topic | 610 Medicine & health |
| url | https://repository.londonmet.ac.uk/6067/1/1-s2.0-S0753332220309057-main.pdf |
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