Identification of similar epitopes between SARS-CoV-2 and Bacillus Calmette-Guérin: potential for cross-reactive adaptive immunity
Objectives: Bacillus Calmette–Guérin (BCG) vaccination has been implicated in protection against SARS-CoV-2 and as a non-specific immunization method against the virus. We therefore decided to investigate T cell and B cell epitopes within the BCG Pasteur strain proteome for similarity to immunogeni...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Wiley
2020
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| Subjects: | |
| Online Access: | https://repository.londonmet.ac.uk/6221/1/Manuscript_full-revised-161120.pdf https://repository.londonmet.ac.uk/6221/2/cti2.1227.pdf |
| _version_ | 1804072580918804480 |
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| author | Urbán, Szabolcs Paragi, Gábor Burián, Katalin McLean, Gary R. Virok, Dezső P. |
| author_facet | Urbán, Szabolcs Paragi, Gábor Burián, Katalin McLean, Gary R. Virok, Dezső P. |
| author_sort | Urbán, Szabolcs |
| collection | LMU |
| description | Objectives:
Bacillus Calmette–Guérin (BCG) vaccination has been implicated in protection against SARS-CoV-2 and as a non-specific immunization method against the virus. We therefore decided to investigate T cell and B cell epitopes within the BCG Pasteur strain proteome for similarity to immunogenic peptides of SARS-CoV-2.
Methods:
We used a bioinformatic approach and analyzed the BCG-Pasteur proteome to identify similar peptides to established and novel SARS-CoV-2 T cell and B cell epitopes.
Results:
We found 112 BCG MHC-I restricted T cell epitopes similar to MHC-I restricted T cell SARS-CoV-2 epitopes and 690 BCG B cell epitopes similar to SARS-CoV-2 B cell epitopes. The SARS-CoV-2 T cell epitopes represented 16 SARS-CoV-2 proteins, the SARS-CoV-2 B cell epitopes represented 5 SARS-CoV-2 proteins, including the receptor binding domain of the spike glycoprotein.
Conclusion:
Altogether our results provide a mechanistic basis for the potential cross-reactive adaptive immunity that may exists between the two microorganisms. |
| first_indexed | 2024-07-09T04:01:25Z |
| format | Article |
| id | oai:repository.londonmet.ac.uk:6221 |
| institution | London Metropolitan University |
| language | English English |
| last_indexed | 2024-07-09T04:01:25Z |
| publishDate | 2020 |
| publisher | Wiley |
| record_format | eprints |
| spelling | oai:repository.londonmet.ac.uk:62212021-03-12T10:46:01Z http://repository.londonmet.ac.uk/6221/ Identification of similar epitopes between SARS-CoV-2 and Bacillus Calmette-Guérin: potential for cross-reactive adaptive immunity Urbán, Szabolcs Paragi, Gábor Burián, Katalin McLean, Gary R. Virok, Dezső P. 570 Life sciences; biology Objectives: Bacillus Calmette–Guérin (BCG) vaccination has been implicated in protection against SARS-CoV-2 and as a non-specific immunization method against the virus. We therefore decided to investigate T cell and B cell epitopes within the BCG Pasteur strain proteome for similarity to immunogenic peptides of SARS-CoV-2. Methods: We used a bioinformatic approach and analyzed the BCG-Pasteur proteome to identify similar peptides to established and novel SARS-CoV-2 T cell and B cell epitopes. Results: We found 112 BCG MHC-I restricted T cell epitopes similar to MHC-I restricted T cell SARS-CoV-2 epitopes and 690 BCG B cell epitopes similar to SARS-CoV-2 B cell epitopes. The SARS-CoV-2 T cell epitopes represented 16 SARS-CoV-2 proteins, the SARS-CoV-2 B cell epitopes represented 5 SARS-CoV-2 proteins, including the receptor binding domain of the spike glycoprotein. Conclusion: Altogether our results provide a mechanistic basis for the potential cross-reactive adaptive immunity that may exists between the two microorganisms. Wiley 2020-12-09 Article PeerReviewed text en cc_by_4 https://repository.londonmet.ac.uk/6221/1/Manuscript_full-revised-161120.pdf text en cc_by_nc_nd_4 https://repository.londonmet.ac.uk/6221/2/cti2.1227.pdf Urbán, Szabolcs, Paragi, Gábor, Burián, Katalin, McLean, Gary R. and Virok, Dezső P. (2020) Identification of similar epitopes between SARS-CoV-2 and Bacillus Calmette-Guérin: potential for cross-reactive adaptive immunity. Clinical & Translational Immunology, 9 (12). pp. 1-8. ISSN 2050-0068 https://doi.org/10.1002/cti2.1227 10.1002/cti2.1227 |
| spellingShingle | 570 Life sciences; biology Urbán, Szabolcs Paragi, Gábor Burián, Katalin McLean, Gary R. Virok, Dezső P. Identification of similar epitopes between SARS-CoV-2 and Bacillus Calmette-Guérin: potential for cross-reactive adaptive immunity |
| title | Identification of similar epitopes between SARS-CoV-2 and Bacillus Calmette-Guérin: potential for cross-reactive adaptive immunity |
| title_full | Identification of similar epitopes between SARS-CoV-2 and Bacillus Calmette-Guérin: potential for cross-reactive adaptive immunity |
| title_fullStr | Identification of similar epitopes between SARS-CoV-2 and Bacillus Calmette-Guérin: potential for cross-reactive adaptive immunity |
| title_full_unstemmed | Identification of similar epitopes between SARS-CoV-2 and Bacillus Calmette-Guérin: potential for cross-reactive adaptive immunity |
| title_short | Identification of similar epitopes between SARS-CoV-2 and Bacillus Calmette-Guérin: potential for cross-reactive adaptive immunity |
| title_sort | identification of similar epitopes between sars cov 2 and bacillus calmette guerin potential for cross reactive adaptive immunity |
| topic | 570 Life sciences; biology |
| url | https://repository.londonmet.ac.uk/6221/1/Manuscript_full-revised-161120.pdf https://repository.londonmet.ac.uk/6221/2/cti2.1227.pdf |
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