A high-protein and low-glycemic formula diet improves blood pressure and other hemodynamic parameters in high-risk individuals
Low-caloric formula diets can improve hemodynamic parameters of patients with type 2 diabetes. We, therefore, hypothesized that persons with overweight or obesity can benefit from a high-protein, low-glycemic but moderate-caloric formula diet. This post-hoc analysis of the Almased Concept against Ov...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI
2022
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| Online Access: | https://repository.londonmet.ac.uk/7353/1/nutrients-14-01443-v2.pdf |
| _version_ | 1804072737431355392 |
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| author | Röhling, Martin Kempf, Kerstin Banzer, Winfried Braumann, Klaus-Michael Führer-Sakel, Dagmar Halle, Martin McCarthy, H. David Martin, Stephan Scholze, Jürgen Toplak, Hermann Berg, Aloys Predel, Hans-Georg |
| author_facet | Röhling, Martin Kempf, Kerstin Banzer, Winfried Braumann, Klaus-Michael Führer-Sakel, Dagmar Halle, Martin McCarthy, H. David Martin, Stephan Scholze, Jürgen Toplak, Hermann Berg, Aloys Predel, Hans-Georg |
| author_sort | Röhling, Martin |
| collection | LMU |
| description | Low-caloric formula diets can improve hemodynamic parameters of patients with type 2 diabetes. We, therefore, hypothesized that persons with overweight or obesity can benefit from a high-protein, low-glycemic but moderate-caloric formula diet. This post-hoc analysis of the Almased Concept against Overweight and Obesity and Related Health Risk- (ACOORH) trial investigated the impact of a lifestyle intervention combined with a formula diet (INT, n = 308) compared to a control group with lifestyle intervention alone (CON, n = 155) on hemodynamic parameters (systolic and diastolic blood pressure (SBP, DBP), resting heart rate (HR), and pulse wave velocity (PWV)) in high-risk individuals with prehypertension or hypertension. INT replaced meals during the first 6 months (1 week: 3 meals/day; 2−4 weeks: 2 meals/day; 5−26 weeks: 1 meal/day). Study duration was 12 months. From the starting cohort, 304 (68.3%, INT: n = 216; CON: n = 101) participants had a complete dataset. Compared to CON, INT significantly reduced more SBP (−7.3 mmHg 95% CI [−9.2; −5.3] vs. −3.3 mmHg [−5.9; −0.8], p 0.049) and DBP (−3.7 mmHg [−4.9; −2.5] vs. −1.4 mmHg [−3.1; 0.2], p 0.028) after 12 months. Compared to CON, INT showed a pronounced reduction in resting HR and PWV after 6 months but both lost significance after 12 months. Changes in SBP, DBP, and PWV were significantly associated positively with changes in body weight and fat mass (all p 0.05) and resting HR correlated positively with fasting insulin (p 0.001) after 12 months. Combining a lifestyle intervention with a high-protein and low-glycemic formula diet improves hemodynamic parameters to a greater extent than lifestyle intervention alone in high-risk individuals with overweight and obesity. |
| first_indexed | 2024-07-09T04:03:54Z |
| format | Article |
| id | oai:repository.londonmet.ac.uk:7353 |
| institution | London Metropolitan University |
| language | English |
| last_indexed | 2024-07-09T04:03:54Z |
| publishDate | 2022 |
| publisher | MDPI |
| record_format | eprints |
| spelling | oai:repository.londonmet.ac.uk:73532022-08-12T12:06:28Z http://repository.londonmet.ac.uk/7353/ A high-protein and low-glycemic formula diet improves blood pressure and other hemodynamic parameters in high-risk individuals Röhling, Martin Kempf, Kerstin Banzer, Winfried Braumann, Klaus-Michael Führer-Sakel, Dagmar Halle, Martin McCarthy, H. David Martin, Stephan Scholze, Jürgen Toplak, Hermann Berg, Aloys Predel, Hans-Georg 610 Medicine & health Low-caloric formula diets can improve hemodynamic parameters of patients with type 2 diabetes. We, therefore, hypothesized that persons with overweight or obesity can benefit from a high-protein, low-glycemic but moderate-caloric formula diet. This post-hoc analysis of the Almased Concept against Overweight and Obesity and Related Health Risk- (ACOORH) trial investigated the impact of a lifestyle intervention combined with a formula diet (INT, n = 308) compared to a control group with lifestyle intervention alone (CON, n = 155) on hemodynamic parameters (systolic and diastolic blood pressure (SBP, DBP), resting heart rate (HR), and pulse wave velocity (PWV)) in high-risk individuals with prehypertension or hypertension. INT replaced meals during the first 6 months (1 week: 3 meals/day; 2−4 weeks: 2 meals/day; 5−26 weeks: 1 meal/day). Study duration was 12 months. From the starting cohort, 304 (68.3%, INT: n = 216; CON: n = 101) participants had a complete dataset. Compared to CON, INT significantly reduced more SBP (−7.3 mmHg 95% CI [−9.2; −5.3] vs. −3.3 mmHg [−5.9; −0.8], p 0.049) and DBP (−3.7 mmHg [−4.9; −2.5] vs. −1.4 mmHg [−3.1; 0.2], p 0.028) after 12 months. Compared to CON, INT showed a pronounced reduction in resting HR and PWV after 6 months but both lost significance after 12 months. Changes in SBP, DBP, and PWV were significantly associated positively with changes in body weight and fat mass (all p 0.05) and resting HR correlated positively with fasting insulin (p 0.001) after 12 months. Combining a lifestyle intervention with a high-protein and low-glycemic formula diet improves hemodynamic parameters to a greater extent than lifestyle intervention alone in high-risk individuals with overweight and obesity. MDPI 2022-03-30 Article PeerReviewed text en cc_by_4 https://repository.londonmet.ac.uk/7353/1/nutrients-14-01443-v2.pdf Röhling, Martin, Kempf, Kerstin, Banzer, Winfried, Braumann, Klaus-Michael, Führer-Sakel, Dagmar, Halle, Martin, McCarthy, H. David, Martin, Stephan, Scholze, Jürgen, Toplak, Hermann, Berg, Aloys and Predel, Hans-Georg (2022) A high-protein and low-glycemic formula diet improves blood pressure and other hemodynamic parameters in high-risk individuals. Nutrients, 14 (7). pp. 1-13. ISSN 2072-6643 https://doi.org/10.3390/nu14071443 10.3390/nu14071443 |
| spellingShingle | 610 Medicine & health Röhling, Martin Kempf, Kerstin Banzer, Winfried Braumann, Klaus-Michael Führer-Sakel, Dagmar Halle, Martin McCarthy, H. David Martin, Stephan Scholze, Jürgen Toplak, Hermann Berg, Aloys Predel, Hans-Georg A high-protein and low-glycemic formula diet improves blood pressure and other hemodynamic parameters in high-risk individuals |
| title | A high-protein and low-glycemic formula diet improves blood pressure and other hemodynamic parameters in high-risk individuals |
| title_full | A high-protein and low-glycemic formula diet improves blood pressure and other hemodynamic parameters in high-risk individuals |
| title_fullStr | A high-protein and low-glycemic formula diet improves blood pressure and other hemodynamic parameters in high-risk individuals |
| title_full_unstemmed | A high-protein and low-glycemic formula diet improves blood pressure and other hemodynamic parameters in high-risk individuals |
| title_short | A high-protein and low-glycemic formula diet improves blood pressure and other hemodynamic parameters in high-risk individuals |
| title_sort | high protein and low glycemic formula diet improves blood pressure and other hemodynamic parameters in high risk individuals |
| topic | 610 Medicine & health |
| url | https://repository.londonmet.ac.uk/7353/1/nutrients-14-01443-v2.pdf |
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