Factors that contribute to hIAPP amyloidosis in type 2 diabetes mellitus
Cases of Type 2 Diabetes Mellitus (T2DM) are increasing at an alarming rate due to the rise in obesity, sedentary lifestyles, glucose-rich diets and other factors. Numerous studies have increasingly illustrated the pivotal role that human islet amyloid polypeptide (hIAPP) plays in the pathology of T...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI
2022
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| Online Access: | https://repository.londonmet.ac.uk/7638/1/life-12-00583.pdf |
| _version_ | 1804072802149466112 |
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| author | Sevcuka, Adriana White, Kenneth Terry, Cassandra |
| author_facet | Sevcuka, Adriana White, Kenneth Terry, Cassandra |
| author_sort | Sevcuka, Adriana |
| collection | LMU |
| description | Cases of Type 2 Diabetes Mellitus (T2DM) are increasing at an alarming rate due to the rise in obesity, sedentary lifestyles, glucose-rich diets and other factors. Numerous studies have increasingly illustrated the pivotal role that human islet amyloid polypeptide (hIAPP) plays in the pathology of T2DM through damage and subsequent loss of pancreatic β-cell mass. HIAPP can misfold and form amyloid fibrils which are preceded by pre-fibrillar oligomers and monomers, all of which have been linked, to a certain extent, to β-cell cytotoxicity through a range of proposed mechanisms. This review provides an up-to-date summary of recent progress in the field, highlighting factors that contribute to hIAPP misfolding and aggregation such as hIAPP protein concentration, cell stress, molecular chaperones, the immune system response and cross-seeding with other amyloidogenic proteins. Understanding the structure of hIAPP and how these factors affect amyloid formation will help us better understand how hIAPP misfolds and aggregates and, importantly, help identify potential therapeutic targets for inhibiting amyloidosis so alternate and more effective treatments for T2DM can be developed. |
| first_indexed | 2024-07-09T04:04:56Z |
| format | Article |
| id | oai:repository.londonmet.ac.uk:7638 |
| institution | London Metropolitan University |
| language | English |
| last_indexed | 2024-07-09T04:04:56Z |
| publishDate | 2022 |
| publisher | MDPI |
| record_format | eprints |
| spelling | oai:repository.londonmet.ac.uk:76382024-02-05T11:42:50Z http://repository.londonmet.ac.uk/7638/ Factors that contribute to hIAPP amyloidosis in type 2 diabetes mellitus Sevcuka, Adriana White, Kenneth Terry, Cassandra 610 Medicine & health Cases of Type 2 Diabetes Mellitus (T2DM) are increasing at an alarming rate due to the rise in obesity, sedentary lifestyles, glucose-rich diets and other factors. Numerous studies have increasingly illustrated the pivotal role that human islet amyloid polypeptide (hIAPP) plays in the pathology of T2DM through damage and subsequent loss of pancreatic β-cell mass. HIAPP can misfold and form amyloid fibrils which are preceded by pre-fibrillar oligomers and monomers, all of which have been linked, to a certain extent, to β-cell cytotoxicity through a range of proposed mechanisms. This review provides an up-to-date summary of recent progress in the field, highlighting factors that contribute to hIAPP misfolding and aggregation such as hIAPP protein concentration, cell stress, molecular chaperones, the immune system response and cross-seeding with other amyloidogenic proteins. Understanding the structure of hIAPP and how these factors affect amyloid formation will help us better understand how hIAPP misfolds and aggregates and, importantly, help identify potential therapeutic targets for inhibiting amyloidosis so alternate and more effective treatments for T2DM can be developed. MDPI 2022-04-14 Article PeerReviewed text en cc_by_4 https://repository.londonmet.ac.uk/7638/1/life-12-00583.pdf Sevcuka, Adriana, White, Kenneth and Terry, Cassandra (2022) Factors that contribute to hIAPP amyloidosis in type 2 diabetes mellitus. Life (Basel, Switzerland), 12 (4) (583). pp. 1-19. ISSN 2075-1729 https://doi.org/10.3390/life12040583 10.3390/life12040583 |
| spellingShingle | 610 Medicine & health Sevcuka, Adriana White, Kenneth Terry, Cassandra Factors that contribute to hIAPP amyloidosis in type 2 diabetes mellitus |
| title | Factors that contribute to hIAPP amyloidosis in type 2 diabetes mellitus |
| title_full | Factors that contribute to hIAPP amyloidosis in type 2 diabetes mellitus |
| title_fullStr | Factors that contribute to hIAPP amyloidosis in type 2 diabetes mellitus |
| title_full_unstemmed | Factors that contribute to hIAPP amyloidosis in type 2 diabetes mellitus |
| title_short | Factors that contribute to hIAPP amyloidosis in type 2 diabetes mellitus |
| title_sort | factors that contribute to hiapp amyloidosis in type 2 diabetes mellitus |
| topic | 610 Medicine & health |
| url | https://repository.londonmet.ac.uk/7638/1/life-12-00583.pdf |
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