Early and strong leptin reduction is predictive for long-term weight loss during high-protein, low-glycaemic meal replacement: a subanalysis of the randomised-controlled ACOORH trial
Lifestyle interventions including meal replacement are suitable for prevention and treatment of obesity and type-2-diabetes. Since leptin is involved in weight regulation, we hypothesised that a meal replacement-based lifestyle intervention would reduce leptin levels more effectively than lifestyle...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI
2022
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| Subjects: | |
| Online Access: | https://repository.londonmet.ac.uk/7800/1/nutrients-14-02537.pdf |
| _version_ | 1804072825083920384 |
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| author | Kempf, Kerstin Röhling, Martin Banzer, Winfried Braumann, Klaus-Michael Halle, Martin Schaller, Nina McCarthy, H. David Predel, Hans Georg Schenkenberger, Isabelle Tan, Susanne Toplak, Hermann Martin, Stephan Berg, Aloys |
| author_facet | Kempf, Kerstin Röhling, Martin Banzer, Winfried Braumann, Klaus-Michael Halle, Martin Schaller, Nina McCarthy, H. David Predel, Hans Georg Schenkenberger, Isabelle Tan, Susanne Toplak, Hermann Martin, Stephan Berg, Aloys |
| author_sort | Kempf, Kerstin |
| collection | LMU |
| description | Lifestyle interventions including meal replacement are suitable for prevention and treatment of obesity and type-2-diabetes. Since leptin is involved in weight regulation, we hypothesised that a meal replacement-based lifestyle intervention would reduce leptin levels more effectively than lifestyle intervention alone. In the international, multicentre, randomised-controlled ACOORH-trial (Almased-Concept-against-Overweight-and-Obesity-and-Related- Health-Risk), overweight or obese participants with metabolic syndrome criteria ( = 463) were randomised into two groups and received telemonitoring devices and nutritional advice. The intervention group additionally used a protein-rich, low-glycaemic meal replacement. Data were collected at baseline, after 1, 3, 6, and 12 months. All datasets providing leptin data ( = 427) were included in this predefined subanalysis. Serum leptin levels significantly correlated with sex, body mass index, weight, and fat mass at baseline ( < 0.0001). Stronger leptin reduction has been observed in the intervention compared to the control group with the lowest levels after 1 month of intervention (estimated treatment difference -3.4 µg/L [1.4; 5.4] for females; -2.2 µg/L [1.2; 3.3] for males; < 0.001 each) and was predictive for stronger reduction of body weight and fat mass ( < 0.001 each) over 12 months. Strongest weight loss was observed after 6 months (-5.9 ± 5.1 kg in females of the intervention group vs. -2.9 ± 4.9 kg in the control group ( < 0.0001); -6.8 ± 5.3 kg vs. -4.1 ± 4.4 kg ( = 0.003) in males) and in those participants with combined leptin and insulin decrease. A meal replacement-based lifestyle intervention effectively reduces leptin which is predictive for long-term weight loss. |
| first_indexed | 2024-07-09T04:05:18Z |
| format | Article |
| id | oai:repository.londonmet.ac.uk:7800 |
| institution | London Metropolitan University |
| language | English |
| last_indexed | 2024-07-09T04:05:18Z |
| publishDate | 2022 |
| publisher | MDPI |
| record_format | eprints |
| spelling | oai:repository.londonmet.ac.uk:78002022-08-12T11:56:04Z http://repository.londonmet.ac.uk/7800/ Early and strong leptin reduction is predictive for long-term weight loss during high-protein, low-glycaemic meal replacement: a subanalysis of the randomised-controlled ACOORH trial Kempf, Kerstin Röhling, Martin Banzer, Winfried Braumann, Klaus-Michael Halle, Martin Schaller, Nina McCarthy, H. David Predel, Hans Georg Schenkenberger, Isabelle Tan, Susanne Toplak, Hermann Martin, Stephan Berg, Aloys 610 Medicine & health Lifestyle interventions including meal replacement are suitable for prevention and treatment of obesity and type-2-diabetes. Since leptin is involved in weight regulation, we hypothesised that a meal replacement-based lifestyle intervention would reduce leptin levels more effectively than lifestyle intervention alone. In the international, multicentre, randomised-controlled ACOORH-trial (Almased-Concept-against-Overweight-and-Obesity-and-Related- Health-Risk), overweight or obese participants with metabolic syndrome criteria ( = 463) were randomised into two groups and received telemonitoring devices and nutritional advice. The intervention group additionally used a protein-rich, low-glycaemic meal replacement. Data were collected at baseline, after 1, 3, 6, and 12 months. All datasets providing leptin data ( = 427) were included in this predefined subanalysis. Serum leptin levels significantly correlated with sex, body mass index, weight, and fat mass at baseline ( < 0.0001). Stronger leptin reduction has been observed in the intervention compared to the control group with the lowest levels after 1 month of intervention (estimated treatment difference -3.4 µg/L [1.4; 5.4] for females; -2.2 µg/L [1.2; 3.3] for males; < 0.001 each) and was predictive for stronger reduction of body weight and fat mass ( < 0.001 each) over 12 months. Strongest weight loss was observed after 6 months (-5.9 ± 5.1 kg in females of the intervention group vs. -2.9 ± 4.9 kg in the control group ( < 0.0001); -6.8 ± 5.3 kg vs. -4.1 ± 4.4 kg ( = 0.003) in males) and in those participants with combined leptin and insulin decrease. A meal replacement-based lifestyle intervention effectively reduces leptin which is predictive for long-term weight loss. MDPI 2022-06-18 Article PeerReviewed text en cc_by_4 https://repository.londonmet.ac.uk/7800/1/nutrients-14-02537.pdf Kempf, Kerstin, Röhling, Martin, Banzer, Winfried, Braumann, Klaus-Michael, Halle, Martin, Schaller, Nina, McCarthy, H. David, Predel, Hans Georg, Schenkenberger, Isabelle, Tan, Susanne, Toplak, Hermann, Martin, Stephan and Berg, Aloys (2022) Early and strong leptin reduction is predictive for long-term weight loss during high-protein, low-glycaemic meal replacement: a subanalysis of the randomised-controlled ACOORH trial. Nutrients, 14 (12). pp. 1-14. ISSN 2072-6643 https://doi.org/10.3390/nu14122537 10.3390/nu14122537 |
| spellingShingle | 610 Medicine & health Kempf, Kerstin Röhling, Martin Banzer, Winfried Braumann, Klaus-Michael Halle, Martin Schaller, Nina McCarthy, H. David Predel, Hans Georg Schenkenberger, Isabelle Tan, Susanne Toplak, Hermann Martin, Stephan Berg, Aloys Early and strong leptin reduction is predictive for long-term weight loss during high-protein, low-glycaemic meal replacement: a subanalysis of the randomised-controlled ACOORH trial |
| title | Early and strong leptin reduction is predictive for long-term weight loss during high-protein, low-glycaemic meal replacement: a subanalysis of the randomised-controlled ACOORH trial |
| title_full | Early and strong leptin reduction is predictive for long-term weight loss during high-protein, low-glycaemic meal replacement: a subanalysis of the randomised-controlled ACOORH trial |
| title_fullStr | Early and strong leptin reduction is predictive for long-term weight loss during high-protein, low-glycaemic meal replacement: a subanalysis of the randomised-controlled ACOORH trial |
| title_full_unstemmed | Early and strong leptin reduction is predictive for long-term weight loss during high-protein, low-glycaemic meal replacement: a subanalysis of the randomised-controlled ACOORH trial |
| title_short | Early and strong leptin reduction is predictive for long-term weight loss during high-protein, low-glycaemic meal replacement: a subanalysis of the randomised-controlled ACOORH trial |
| title_sort | early and strong leptin reduction is predictive for long term weight loss during high protein low glycaemic meal replacement a subanalysis of the randomised controlled acoorh trial |
| topic | 610 Medicine & health |
| url | https://repository.londonmet.ac.uk/7800/1/nutrients-14-02537.pdf |
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