High-protein, low-glycaemic meal replacement improves physical health-related quality of life in high-risk persons for metabolic syndrome—a subanalysis of the randomised-controlled ACOORH trial
While obesity impairs health-related quality of life (HRQOL), lifestyle interventions targeting weight reduction have been effective in improving HRQOL. Therefore, we hypothesised that a meal replacement-based lifestyle intervention, which has been shown to successfully reduce weight, would also imp...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI
2022
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| Subjects: | |
| Online Access: | https://repository.londonmet.ac.uk/7843/1/nutrients-14-03161-v3.pdf |
| _version_ | 1804072828652224512 |
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| author | Kempf, Kerstin Röhling, Martin Banzer, Winfried Braumann, Klaus-Michael Halle, Martin Schaller, Nina McCarthy, H. David Predel, Hans-Georg Schenkenberger, Isabelle Tan, Susanne Toplak, Hermann Martin, Stephan Berg, Aloys |
| author_facet | Kempf, Kerstin Röhling, Martin Banzer, Winfried Braumann, Klaus-Michael Halle, Martin Schaller, Nina McCarthy, H. David Predel, Hans-Georg Schenkenberger, Isabelle Tan, Susanne Toplak, Hermann Martin, Stephan Berg, Aloys |
| author_sort | Kempf, Kerstin |
| collection | LMU |
| description | While obesity impairs health-related quality of life (HRQOL), lifestyle interventions targeting weight reduction have been effective in improving HRQOL. Therefore, we hypothesised that a meal replacement-based lifestyle intervention, which has been shown to successfully reduce weight, would also improve HRQOL more effectively than a lifestyle intervention alone. In the international, multicenter, randomised-controlled ACOORH-trial (Almased-Concept-against- Overweight-and-Obesity-and-Related-Health-Risk), overweight or obese participants with elevated risk for metabolic syndrome (n = 463) were randomised into two groups. Both groups received telemonitoring devices and nutritional advice. The intervention group additionally used a protein-rich, low-glycaemic meal replacement for 6 months. HRQOL was estimated at baseline, after 3 and 12 months, using the SF-36 questionnaire, and all datasets providing HRQOL data (n = 263) were included in this predefined subanalysis. Stronger improvements in the physical component summary (PCS) were observed in the intervention compared to the control group, peaking after 3 months (estimated treatment difference 2.7 [1.2; 4.2]; p 0.0001), but also in the long-term. Multiple regression analysis demonstrated that insulin levels and the achieved weight loss were associated with the mental component summary (MCS) after 12 months (p 0.05). Thus, meal replacement-based lifestyle intervention is not only effective in weight reduction but, concomitantly, in enhancing HRQOL. |
| first_indexed | 2024-07-09T04:05:21Z |
| format | Article |
| id | oai:repository.londonmet.ac.uk:7843 |
| institution | London Metropolitan University |
| language | English |
| last_indexed | 2024-07-09T04:05:21Z |
| publishDate | 2022 |
| publisher | MDPI |
| record_format | eprints |
| spelling | oai:repository.londonmet.ac.uk:78432022-08-12T12:19:43Z http://repository.londonmet.ac.uk/7843/ High-protein, low-glycaemic meal replacement improves physical health-related quality of life in high-risk persons for metabolic syndrome—a subanalysis of the randomised-controlled ACOORH trial Kempf, Kerstin Röhling, Martin Banzer, Winfried Braumann, Klaus-Michael Halle, Martin Schaller, Nina McCarthy, H. David Predel, Hans-Georg Schenkenberger, Isabelle Tan, Susanne Toplak, Hermann Martin, Stephan Berg, Aloys 610 Medicine & health While obesity impairs health-related quality of life (HRQOL), lifestyle interventions targeting weight reduction have been effective in improving HRQOL. Therefore, we hypothesised that a meal replacement-based lifestyle intervention, which has been shown to successfully reduce weight, would also improve HRQOL more effectively than a lifestyle intervention alone. In the international, multicenter, randomised-controlled ACOORH-trial (Almased-Concept-against- Overweight-and-Obesity-and-Related-Health-Risk), overweight or obese participants with elevated risk for metabolic syndrome (n = 463) were randomised into two groups. Both groups received telemonitoring devices and nutritional advice. The intervention group additionally used a protein-rich, low-glycaemic meal replacement for 6 months. HRQOL was estimated at baseline, after 3 and 12 months, using the SF-36 questionnaire, and all datasets providing HRQOL data (n = 263) were included in this predefined subanalysis. Stronger improvements in the physical component summary (PCS) were observed in the intervention compared to the control group, peaking after 3 months (estimated treatment difference 2.7 [1.2; 4.2]; p 0.0001), but also in the long-term. Multiple regression analysis demonstrated that insulin levels and the achieved weight loss were associated with the mental component summary (MCS) after 12 months (p 0.05). Thus, meal replacement-based lifestyle intervention is not only effective in weight reduction but, concomitantly, in enhancing HRQOL. MDPI 2022-07-30 Article PeerReviewed text en cc_by_4 https://repository.londonmet.ac.uk/7843/1/nutrients-14-03161-v3.pdf Kempf, Kerstin, Röhling, Martin, Banzer, Winfried, Braumann, Klaus-Michael, Halle, Martin, Schaller, Nina, McCarthy, H. David, Predel, Hans-Georg, Schenkenberger, Isabelle, Tan, Susanne, Toplak, Hermann, Martin, Stephan and Berg, Aloys (2022) High-protein, low-glycaemic meal replacement improves physical health-related quality of life in high-risk persons for metabolic syndrome—a subanalysis of the randomised-controlled ACOORH trial. Nutrients, 14 (15). pp. 1-12. ISSN 2072-6643 https://doi.org/10.3390/nu14153161 10.3390/nu14153161 |
| spellingShingle | 610 Medicine & health Kempf, Kerstin Röhling, Martin Banzer, Winfried Braumann, Klaus-Michael Halle, Martin Schaller, Nina McCarthy, H. David Predel, Hans-Georg Schenkenberger, Isabelle Tan, Susanne Toplak, Hermann Martin, Stephan Berg, Aloys High-protein, low-glycaemic meal replacement improves physical health-related quality of life in high-risk persons for metabolic syndrome—a subanalysis of the randomised-controlled ACOORH trial |
| title | High-protein, low-glycaemic meal replacement improves physical health-related quality of life in high-risk persons for metabolic syndrome—a subanalysis of the randomised-controlled ACOORH trial |
| title_full | High-protein, low-glycaemic meal replacement improves physical health-related quality of life in high-risk persons for metabolic syndrome—a subanalysis of the randomised-controlled ACOORH trial |
| title_fullStr | High-protein, low-glycaemic meal replacement improves physical health-related quality of life in high-risk persons for metabolic syndrome—a subanalysis of the randomised-controlled ACOORH trial |
| title_full_unstemmed | High-protein, low-glycaemic meal replacement improves physical health-related quality of life in high-risk persons for metabolic syndrome—a subanalysis of the randomised-controlled ACOORH trial |
| title_short | High-protein, low-glycaemic meal replacement improves physical health-related quality of life in high-risk persons for metabolic syndrome—a subanalysis of the randomised-controlled ACOORH trial |
| title_sort | high protein low glycaemic meal replacement improves physical health related quality of life in high risk persons for metabolic syndrome a subanalysis of the randomised controlled acoorh trial |
| topic | 610 Medicine & health |
| url | https://repository.londonmet.ac.uk/7843/1/nutrients-14-03161-v3.pdf |
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