Developing rat testicular organoid models for assessing the reproductive toxicity of antidepression drugs in vitro
With the increasing incidence of depression worldwide, antidepressant medications are commonly used in males of reproductive age for long-term treatment of depression, as well as other disorders. Antidepressants are known to be associated with sexual side effects, such as decreased libido and impote...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SciEngine
2022
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| Online Access: | https://repository.londonmet.ac.uk/8038/1/271E5E9956784473A54C76FB9927074E.pdf |
| _version_ | 1825625753442582528 |
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| author | Wu, Sixian Li, Xiaoliang Li, Peiyu Li, Tongtong Huang, Gelin Sun, Qun Dinnyés, Andras Shang, Lijun Xu, Wenming |
| author_facet | Wu, Sixian Li, Xiaoliang Li, Peiyu Li, Tongtong Huang, Gelin Sun, Qun Dinnyés, Andras Shang, Lijun Xu, Wenming |
| author_sort | Wu, Sixian |
| collection | LMU |
| description | With the increasing incidence of depression worldwide, antidepressant medications are commonly used in males of reproductive age for long-term treatment of depression, as well as other disorders. Antidepressants are known to be associated with sexual side effects, such as decreased libido and impotence. Their effects on semen parameters and other markers of male fertility have been less thoroughly described, such as sperm motility and fertilization ability. Therefore, it is critical to determine the potential toxic effects of antidepressants on reproductive organs. A recent study systemically determined the effect of different drugs on the telomere-related DNA damage response of germ cells. In addition, another study showed that mirtazapine has less toxic effects than amitriptyline and other drugs. However, these studies used germ cell lines to determine the phenotype, which limits their potential translational value in toxicity studies in humans. Given the widespread and often long-term use of antidepressant medications, there is an urgent need for further data regarding their impact on semen quality and subsequent male fertility. |
| first_indexed | 2024-07-09T04:05:45Z |
| format | Article |
| id | oai:repository.londonmet.ac.uk:8038 |
| institution | London Metropolitan University |
| language | English |
| last_indexed | 2024-07-09T04:05:45Z |
| publishDate | 2022 |
| publisher | SciEngine |
| record_format | eprints |
| spelling | oai:repository.londonmet.ac.uk:80382023-01-20T16:15:19Z https://repository.londonmet.ac.uk/8038/ Developing rat testicular organoid models for assessing the reproductive toxicity of antidepression drugs in vitro Wu, Sixian Li, Xiaoliang Li, Peiyu Li, Tongtong Huang, Gelin Sun, Qun Dinnyés, Andras Shang, Lijun Xu, Wenming 570 Life sciences; biology With the increasing incidence of depression worldwide, antidepressant medications are commonly used in males of reproductive age for long-term treatment of depression, as well as other disorders. Antidepressants are known to be associated with sexual side effects, such as decreased libido and impotence. Their effects on semen parameters and other markers of male fertility have been less thoroughly described, such as sperm motility and fertilization ability. Therefore, it is critical to determine the potential toxic effects of antidepressants on reproductive organs. A recent study systemically determined the effect of different drugs on the telomere-related DNA damage response of germ cells. In addition, another study showed that mirtazapine has less toxic effects than amitriptyline and other drugs. However, these studies used germ cell lines to determine the phenotype, which limits their potential translational value in toxicity studies in humans. Given the widespread and often long-term use of antidepressant medications, there is an urgent need for further data regarding their impact on semen quality and subsequent male fertility. SciEngine 2022-11-25 Article PeerReviewed text en cc_by_4 https://repository.londonmet.ac.uk/8038/1/271E5E9956784473A54C76FB9927074E.pdf Wu, Sixian, Li, Xiaoliang, Li, Peiyu, Li, Tongtong, Huang, Gelin, Sun, Qun, Dinnyés, Andras, Shang, Lijun and Xu, Wenming (2022) Developing rat testicular organoid models for assessing the reproductive toxicity of antidepression drugs in vitro. Acta Biochimica et Biophysica Sinica, 54 (11). pp. 1748-1752. ISSN 1745-7270 https://doi.org/10.3724/abbs.2022164 10.3724/abbs.2022164 10.3724/abbs.2022164 |
| spellingShingle | 570 Life sciences; biology Wu, Sixian Li, Xiaoliang Li, Peiyu Li, Tongtong Huang, Gelin Sun, Qun Dinnyés, Andras Shang, Lijun Xu, Wenming Developing rat testicular organoid models for assessing the reproductive toxicity of antidepression drugs in vitro |
| title | Developing rat testicular organoid models for assessing the reproductive toxicity of antidepression drugs in vitro |
| title_full | Developing rat testicular organoid models for assessing the reproductive toxicity of antidepression drugs in vitro |
| title_fullStr | Developing rat testicular organoid models for assessing the reproductive toxicity of antidepression drugs in vitro |
| title_full_unstemmed | Developing rat testicular organoid models for assessing the reproductive toxicity of antidepression drugs in vitro |
| title_short | Developing rat testicular organoid models for assessing the reproductive toxicity of antidepression drugs in vitro |
| title_sort | developing rat testicular organoid models for assessing the reproductive toxicity of antidepression drugs in vitro |
| topic | 570 Life sciences; biology |
| url | https://repository.londonmet.ac.uk/8038/1/271E5E9956784473A54C76FB9927074E.pdf |
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