The role of excipients in promoting topical and transdermal delivery: current limitations and future perspectives
Topical and transdermal delivery has historically offered an attractive and non-invasive route for administration of medicines. However, human skin is known to be a remarkably good barrier to the permeation of substances. The majority of dermatological drug products have been reported to only delive...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media
2022
|
| Subjects: | |
| Online Access: | https://repository.londonmet.ac.uk/8062/1/fddev-02-1049848.pdf |
| _version_ | 1825625755729526784 |
|---|---|
| author | Iliopoulos, Fotis Sil dos Santos, Bruno Evans, Conor L. |
| author_facet | Iliopoulos, Fotis Sil dos Santos, Bruno Evans, Conor L. |
| author_sort | Iliopoulos, Fotis |
| collection | LMU |
| description | Topical and transdermal delivery has historically offered an attractive and non-invasive route for administration of medicines. However, human skin is known to be a remarkably good barrier to the permeation of substances. The majority of dermatological drug products have been reported to only deliver a portion of the total dose applied, often resulting in low drug bio-availability at the site of action inside the skin. This insufficient formulation performance, coupled with the fact that percutaneous delivery is heavily influenced by the innate physicochemical properties of the active, pose limitations on effective treatment and prevention of diseases by using solely topical formulations. Generally, it is known that the rate and the extent of drug delivery to and through the skin is highly dependent on the formulation components. This work highlights the importance of the vehicle for the design of efficacious skin products, discusses current limitations in dermal delivery and explores recent advances for overcoming these challenges. Novel materials with penetration enhancing properties and innovative formulation strategies are also explored, together with future perspectives and outlooks. The emphasis here is on studies focused on passive skin transport, because of clinical limitations associated with disrupting the skin barrier by physical methods. This information is believed to aid in the design and optimization of dermatological drug products for topical and transdermal delivery of actives. |
| first_indexed | 2024-07-09T04:05:47Z |
| format | Article |
| id | oai:repository.londonmet.ac.uk:8062 |
| institution | London Metropolitan University |
| language | English |
| last_indexed | 2024-07-09T04:05:47Z |
| publishDate | 2022 |
| publisher | Frontiers Media |
| record_format | eprints |
| spelling | oai:repository.londonmet.ac.uk:80622023-11-06T12:03:50Z https://repository.londonmet.ac.uk/8062/ The role of excipients in promoting topical and transdermal delivery: current limitations and future perspectives Iliopoulos, Fotis Sil dos Santos, Bruno Evans, Conor L. 540 Chemistry & allied sciences 610 Medicine & health Topical and transdermal delivery has historically offered an attractive and non-invasive route for administration of medicines. However, human skin is known to be a remarkably good barrier to the permeation of substances. The majority of dermatological drug products have been reported to only deliver a portion of the total dose applied, often resulting in low drug bio-availability at the site of action inside the skin. This insufficient formulation performance, coupled with the fact that percutaneous delivery is heavily influenced by the innate physicochemical properties of the active, pose limitations on effective treatment and prevention of diseases by using solely topical formulations. Generally, it is known that the rate and the extent of drug delivery to and through the skin is highly dependent on the formulation components. This work highlights the importance of the vehicle for the design of efficacious skin products, discusses current limitations in dermal delivery and explores recent advances for overcoming these challenges. Novel materials with penetration enhancing properties and innovative formulation strategies are also explored, together with future perspectives and outlooks. The emphasis here is on studies focused on passive skin transport, because of clinical limitations associated with disrupting the skin barrier by physical methods. This information is believed to aid in the design and optimization of dermatological drug products for topical and transdermal delivery of actives. Frontiers Media 2022-12-20 Article PeerReviewed text en cc_by_4 https://repository.londonmet.ac.uk/8062/1/fddev-02-1049848.pdf Iliopoulos, Fotis, Sil dos Santos, Bruno and Evans, Conor L. (2022) The role of excipients in promoting topical and transdermal delivery: current limitations and future perspectives. Frontiers in Drug Delivery, 2 (104984). pp. 1-10. ISSN 2674-0850 https://www.frontiersin.org/articles/10.3389/fddev.2022.1049848 10.3389/fddev.2022.1049848 10.3389/fddev.2022.1049848 |
| spellingShingle | 540 Chemistry & allied sciences 610 Medicine & health Iliopoulos, Fotis Sil dos Santos, Bruno Evans, Conor L. The role of excipients in promoting topical and transdermal delivery: current limitations and future perspectives |
| title | The role of excipients in promoting topical and transdermal delivery: current limitations and future perspectives |
| title_full | The role of excipients in promoting topical and transdermal delivery: current limitations and future perspectives |
| title_fullStr | The role of excipients in promoting topical and transdermal delivery: current limitations and future perspectives |
| title_full_unstemmed | The role of excipients in promoting topical and transdermal delivery: current limitations and future perspectives |
| title_short | The role of excipients in promoting topical and transdermal delivery: current limitations and future perspectives |
| title_sort | role of excipients in promoting topical and transdermal delivery current limitations and future perspectives |
| topic | 540 Chemistry & allied sciences 610 Medicine & health |
| url | https://repository.londonmet.ac.uk/8062/1/fddev-02-1049848.pdf |
| work_keys_str_mv | AT iliopoulosfotis theroleofexcipientsinpromotingtopicalandtransdermaldeliverycurrentlimitationsandfutureperspectives AT sildossantosbruno theroleofexcipientsinpromotingtopicalandtransdermaldeliverycurrentlimitationsandfutureperspectives AT evansconorl theroleofexcipientsinpromotingtopicalandtransdermaldeliverycurrentlimitationsandfutureperspectives AT iliopoulosfotis roleofexcipientsinpromotingtopicalandtransdermaldeliverycurrentlimitationsandfutureperspectives AT sildossantosbruno roleofexcipientsinpromotingtopicalandtransdermaldeliverycurrentlimitationsandfutureperspectives AT evansconorl roleofexcipientsinpromotingtopicalandtransdermaldeliverycurrentlimitationsandfutureperspectives |