Association between iron metabolism and SARS-COV-2 infection, determined by ferritin, hephaestin and hypoxia-induced factor-1 alpha levels in COVID-19 patients
Background: Due to the growing evidence of the importance of iron status in immune responses, the biomarkers of iron metabolism are of interest in novel Coronavirus Disease 2019 (COVID-19). The present prospective study was carried out to compare iron status indicated by levels of ferritin with th...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer Nature
2023
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| Subjects: | |
| Online Access: | https://repository.londonmet.ac.uk/8120/1/11033_2022_8221_OnlinePDF.pdf |
| _version_ | 1825625762117451776 |
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| author | Aslan, Elif Sibel Aydm, Huseyn Tekin, Yusuf Kenan Keles, Sami White, Kenneth Hekim, Nezih |
| author_facet | Aslan, Elif Sibel Aydm, Huseyn Tekin, Yusuf Kenan Keles, Sami White, Kenneth Hekim, Nezih |
| author_sort | Aslan, Elif Sibel |
| collection | LMU |
| description | Background:
Due to the growing evidence of the importance of iron status in immune responses, the biomarkers of iron metabolism are of interest in novel Coronavirus Disease 2019 (COVID-19). The present prospective study was carried out to compare iron status indicated by levels of ferritin with the levels of two novel biomarkers related to iron homeostasis, hephaestin and hypoxia-inducible factors-1 (HIF-1α) in the serum of patients with COVID-19 in comparison with a control group.
Methods and results:
Blood samples from 34 COVID-19 patients and from 43 healthy volunteers were collected and the levels of HEPH and HIF-1α were measured by ELISA and compared with levels of serum ferritin. COVID-19 patients had higher serum levels of ferritin than those levels in control group (P < 0.0001). Conversely levels of HIF-1α and HEPH in the COVID-19 group were significantly lower than those of control group (P < 0.0001 for both). An inverse correlation between hephaestin and ferritin as well as between HIF-1α and ferritin was found among all subjects (P < 0.0001), and among COVID-19 patients, but not to statistical significance.
Conclusion:
Levels of hephaestin and HIF-1α were found to be inversely related levels of ferritin across all participants in the study, and to our knowledge this is the first report of hephaestin and HIF-1α as potential markers of iron status. Further studies are needed to corroborate the findings, utilizing a broader range of markers to monitor inflammatory as well as iron status. |
| first_indexed | 2024-07-09T04:05:54Z |
| format | Article |
| id | oai:repository.londonmet.ac.uk:8120 |
| institution | London Metropolitan University |
| language | English |
| last_indexed | 2024-07-09T04:05:54Z |
| publishDate | 2023 |
| publisher | Springer Nature |
| record_format | eprints |
| spelling | oai:repository.londonmet.ac.uk:81202024-01-05T01:58:11Z https://repository.londonmet.ac.uk/8120/ Association between iron metabolism and SARS-COV-2 infection, determined by ferritin, hephaestin and hypoxia-induced factor-1 alpha levels in COVID-19 patients Aslan, Elif Sibel Aydm, Huseyn Tekin, Yusuf Kenan Keles, Sami White, Kenneth Hekim, Nezih 570 Life sciences; biology 610 Medicine & health Background: Due to the growing evidence of the importance of iron status in immune responses, the biomarkers of iron metabolism are of interest in novel Coronavirus Disease 2019 (COVID-19). The present prospective study was carried out to compare iron status indicated by levels of ferritin with the levels of two novel biomarkers related to iron homeostasis, hephaestin and hypoxia-inducible factors-1 (HIF-1α) in the serum of patients with COVID-19 in comparison with a control group. Methods and results: Blood samples from 34 COVID-19 patients and from 43 healthy volunteers were collected and the levels of HEPH and HIF-1α were measured by ELISA and compared with levels of serum ferritin. COVID-19 patients had higher serum levels of ferritin than those levels in control group (P < 0.0001). Conversely levels of HIF-1α and HEPH in the COVID-19 group were significantly lower than those of control group (P < 0.0001 for both). An inverse correlation between hephaestin and ferritin as well as between HIF-1α and ferritin was found among all subjects (P < 0.0001), and among COVID-19 patients, but not to statistical significance. Conclusion: Levels of hephaestin and HIF-1α were found to be inversely related levels of ferritin across all participants in the study, and to our knowledge this is the first report of hephaestin and HIF-1α as potential markers of iron status. Further studies are needed to corroborate the findings, utilizing a broader range of markers to monitor inflammatory as well as iron status. Springer Nature 2023-01-05 Article PeerReviewed text en https://repository.londonmet.ac.uk/8120/1/11033_2022_8221_OnlinePDF.pdf Aslan, Elif Sibel, Aydm, Huseyn, Tekin, Yusuf Kenan, Keles, Sami, White, Kenneth and Hekim, Nezih (2023) Association between iron metabolism and SARS-COV-2 infection, determined by ferritin, hephaestin and hypoxia-induced factor-1 alpha levels in COVID-19 patients. Molecular Biology Reports, 50 (3). pp. 2471-2478. ISSN 1573-4978 https://doi.org/10.1007/s11033-022-08221-3 10.1007/s11033-022-08221-3 10.1007/s11033-022-08221-3 |
| spellingShingle | 570 Life sciences; biology 610 Medicine & health Aslan, Elif Sibel Aydm, Huseyn Tekin, Yusuf Kenan Keles, Sami White, Kenneth Hekim, Nezih Association between iron metabolism and SARS-COV-2 infection, determined by ferritin, hephaestin and hypoxia-induced factor-1 alpha levels in COVID-19 patients |
| title | Association between iron metabolism and SARS-COV-2 infection, determined by ferritin, hephaestin and hypoxia-induced factor-1 alpha levels in COVID-19 patients |
| title_full | Association between iron metabolism and SARS-COV-2 infection, determined by ferritin, hephaestin and hypoxia-induced factor-1 alpha levels in COVID-19 patients |
| title_fullStr | Association between iron metabolism and SARS-COV-2 infection, determined by ferritin, hephaestin and hypoxia-induced factor-1 alpha levels in COVID-19 patients |
| title_full_unstemmed | Association between iron metabolism and SARS-COV-2 infection, determined by ferritin, hephaestin and hypoxia-induced factor-1 alpha levels in COVID-19 patients |
| title_short | Association between iron metabolism and SARS-COV-2 infection, determined by ferritin, hephaestin and hypoxia-induced factor-1 alpha levels in COVID-19 patients |
| title_sort | association between iron metabolism and sars cov 2 infection determined by ferritin hephaestin and hypoxia induced factor 1 alpha levels in covid 19 patients |
| topic | 570 Life sciences; biology 610 Medicine & health |
| url | https://repository.londonmet.ac.uk/8120/1/11033_2022_8221_OnlinePDF.pdf |
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