The imperative of arachidonic acid in human reproduction
We are presenting new evidence on essential fatty acids (EFA) in prenatal human development. We have demonstrated, for the first time, the detailed process of active selection of some fatty acids by the placenta (biomagnification) and rejection of others (bioreduction) and how this strategy is of su...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English English |
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Elsevier
2023
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| Online Access: | https://repository.londonmet.ac.uk/8316/7/1-s2.0-S0163782723000127-main.pdf https://repository.londonmet.ac.uk/8316/13/The%20imperative%20of%20AA%20in%20human%20reproduction%202023.pdf |
| _version_ | 1804072887451123712 |
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| author | Crawford, Michael A. Sinclair, Andrew J. Hall, Barbara Ogundipe, Enitan Wang, Yiqun Bitsanis, Demetrios Djahanbakhch, Ovrang B. Harbige, Laurence S. Golfetto, Ivan Moodley, Therishnee Hassam, Ahmed Sassine, AnnieBelle Johnson, Mark |
| author_facet | Crawford, Michael A. Sinclair, Andrew J. Hall, Barbara Ogundipe, Enitan Wang, Yiqun Bitsanis, Demetrios Djahanbakhch, Ovrang B. Harbige, Laurence S. Golfetto, Ivan Moodley, Therishnee Hassam, Ahmed Sassine, AnnieBelle Johnson, Mark |
| author_sort | Crawford, Michael A. |
| collection | LMU |
| description | We are presenting new evidence on essential fatty acids (EFA) in prenatal human development. We have demonstrated, for the first time, the detailed process of active selection of some fatty acids by the placenta (biomagnification) and rejection of others (bioreduction) and how this strategy is of supreme importance for understanding of the biology of human reproduction. The biomagnification process by the placenta is dominated by arachidonic acid (ArA) and its allies: di-homo-gamma-linolenic acid (DGLA), adrenic acid and ω6 docosapentaenoic acid. Stearic acid is similarly bio-magnified which is likely to provide for the sn-1 position in membrane synthesis. In contrast there is a bioreduction of oleic, linoleic and all ω3 precursors for docosahexaenoic acid (DHA), including eicosapentaenoic acid (EPA). Although DHA is biomagnified, the amplification from mother to fetus is small compared to ArA. We report on the dominant compartmentalisation of ArA from mother to fetal plasma, cell membranes of red cells, mono-nuclear cells, endothelium and the placenta. We conclude that ArA and its allies, play a paramount role in the development of the products of conception. It is plausible that inadequate provision of ArA may be relevant to the neuro-vascular complications of prematurity and neurodevelopmental disorders associated with premature birth. We present evidence of ArA's universal role from an identical arachidonic acid-based strategy observed in contrasting cultures. The dominance of ArA in the prenatal and in post-natal nutritional provision by human milk makes a compelling case for re-evaluation of its role, especially in reproductive biology. |
| first_indexed | 2024-07-09T04:06:17Z |
| format | Article |
| id | oai:repository.londonmet.ac.uk:8316 |
| institution | London Metropolitan University |
| language | English English |
| last_indexed | 2024-07-09T04:06:17Z |
| publishDate | 2023 |
| publisher | Elsevier |
| record_format | eprints |
| spelling | oai:repository.londonmet.ac.uk:83162024-02-04T01:58:10Z http://repository.londonmet.ac.uk/8316/ The imperative of arachidonic acid in human reproduction Crawford, Michael A. Sinclair, Andrew J. Hall, Barbara Ogundipe, Enitan Wang, Yiqun Bitsanis, Demetrios Djahanbakhch, Ovrang B. Harbige, Laurence S. Golfetto, Ivan Moodley, Therishnee Hassam, Ahmed Sassine, AnnieBelle Johnson, Mark 610 Medicine & health We are presenting new evidence on essential fatty acids (EFA) in prenatal human development. We have demonstrated, for the first time, the detailed process of active selection of some fatty acids by the placenta (biomagnification) and rejection of others (bioreduction) and how this strategy is of supreme importance for understanding of the biology of human reproduction. The biomagnification process by the placenta is dominated by arachidonic acid (ArA) and its allies: di-homo-gamma-linolenic acid (DGLA), adrenic acid and ω6 docosapentaenoic acid. Stearic acid is similarly bio-magnified which is likely to provide for the sn-1 position in membrane synthesis. In contrast there is a bioreduction of oleic, linoleic and all ω3 precursors for docosahexaenoic acid (DHA), including eicosapentaenoic acid (EPA). Although DHA is biomagnified, the amplification from mother to fetus is small compared to ArA. We report on the dominant compartmentalisation of ArA from mother to fetal plasma, cell membranes of red cells, mono-nuclear cells, endothelium and the placenta. We conclude that ArA and its allies, play a paramount role in the development of the products of conception. It is plausible that inadequate provision of ArA may be relevant to the neuro-vascular complications of prematurity and neurodevelopmental disorders associated with premature birth. We present evidence of ArA's universal role from an identical arachidonic acid-based strategy observed in contrasting cultures. The dominance of ArA in the prenatal and in post-natal nutritional provision by human milk makes a compelling case for re-evaluation of its role, especially in reproductive biology. Elsevier 2023-02-04 Article PeerReviewed text en cc_by_nc_nd_4 https://repository.londonmet.ac.uk/8316/7/1-s2.0-S0163782723000127-main.pdf text en cc_by_nd_4 https://repository.londonmet.ac.uk/8316/13/The%20imperative%20of%20AA%20in%20human%20reproduction%202023.pdf Crawford, Michael A., Sinclair, Andrew J., Hall, Barbara, Ogundipe, Enitan, Wang, Yiqun, Bitsanis, Demetrios, Djahanbakhch, Ovrang B., Harbige, Laurence S., Golfetto, Ivan, Moodley, Therishnee, Hassam, Ahmed, Sassine, AnnieBelle and Johnson, Mark (2023) The imperative of arachidonic acid in human reproduction. Progress in lipid research, 91 (101222). pp. 1-22. ISSN 1873-2194 https://doi.org/10.1016/j.plipres.2023.101222 10.1016/j.plipres.2023.101222 |
| spellingShingle | 610 Medicine & health Crawford, Michael A. Sinclair, Andrew J. Hall, Barbara Ogundipe, Enitan Wang, Yiqun Bitsanis, Demetrios Djahanbakhch, Ovrang B. Harbige, Laurence S. Golfetto, Ivan Moodley, Therishnee Hassam, Ahmed Sassine, AnnieBelle Johnson, Mark The imperative of arachidonic acid in human reproduction |
| title | The imperative of arachidonic acid in human reproduction |
| title_full | The imperative of arachidonic acid in human reproduction |
| title_fullStr | The imperative of arachidonic acid in human reproduction |
| title_full_unstemmed | The imperative of arachidonic acid in human reproduction |
| title_short | The imperative of arachidonic acid in human reproduction |
| title_sort | imperative of arachidonic acid in human reproduction |
| topic | 610 Medicine & health |
| url | https://repository.londonmet.ac.uk/8316/7/1-s2.0-S0163782723000127-main.pdf https://repository.londonmet.ac.uk/8316/13/The%20imperative%20of%20AA%20in%20human%20reproduction%202023.pdf |
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