Telomere oxidation status (TOS) is correlated with relative telomere length (RTL) across different mouse tissues but not with nicotinamide nucleotide transhydrogenase (Nnt) status
We demonstrate that tissues with the shortest TL, showed the highest TOS and tissues with the longest TL, the lowest TOS. Surprisingly, murine Nnt status is not associated with TL or TOS. Background Numerous studies imply that oxidative stress is associated with TL but rarely directly assay oxidativ...
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| Format: | Conference or Workshop Item |
| Language: | English |
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Springer Nature
2023
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| Subjects: | |
| Online Access: | https://repository.londonmet.ac.uk/9263/1/ESHG%20Poster%20Telomere%20Length%20and%20Oxidative%20Stress%20Final.pdf |
| _version_ | 1825625881065816064 |
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| author | Kidd, Elliot Meimaridou, Eirini Walley, Andrew Fairbrother, Una |
| author_facet | Kidd, Elliot Meimaridou, Eirini Walley, Andrew Fairbrother, Una |
| author_sort | Kidd, Elliot |
| collection | LMU |
| description | We demonstrate that tissues with the shortest TL, showed the highest TOS and tissues with the longest TL, the lowest TOS. Surprisingly, murine Nnt status is not associated with TL or TOS. Background Numerous studies imply that oxidative stress is associated with TL but rarely directly assay oxidative damage in telomeric DNA. We used a mouse model to demonstrate telomere specific oxidative stress and its effects on TL, in a range of tissues. These mice have a naturally occurring Nnt deficiency. Previous reports suggest that absence of Nnt results in high levels of cellular reactive oxygen species (ROS). We investigated whether Nnt deficient mice have reduced TL and display markers of TOS compared to WT and rescued mice and whether this was tissue specific. |
| first_indexed | 2024-07-09T04:07:58Z |
| format | Conference or Workshop Item |
| id | oai:repository.londonmet.ac.uk:9263 |
| institution | London Metropolitan University |
| language | English |
| last_indexed | 2025-02-19T01:15:29Z |
| publishDate | 2023 |
| publisher | Springer Nature |
| record_format | eprints |
| spelling | oai:repository.londonmet.ac.uk:92632024-07-24T01:58:14Z https://repository.londonmet.ac.uk/9263/ Telomere oxidation status (TOS) is correlated with relative telomere length (RTL) across different mouse tissues but not with nicotinamide nucleotide transhydrogenase (Nnt) status Kidd, Elliot Meimaridou, Eirini Walley, Andrew Fairbrother, Una 570 Life sciences; biology We demonstrate that tissues with the shortest TL, showed the highest TOS and tissues with the longest TL, the lowest TOS. Surprisingly, murine Nnt status is not associated with TL or TOS. Background Numerous studies imply that oxidative stress is associated with TL but rarely directly assay oxidative damage in telomeric DNA. We used a mouse model to demonstrate telomere specific oxidative stress and its effects on TL, in a range of tissues. These mice have a naturally occurring Nnt deficiency. Previous reports suggest that absence of Nnt results in high levels of cellular reactive oxygen species (ROS). We investigated whether Nnt deficient mice have reduced TL and display markers of TOS compared to WT and rescued mice and whether this was tissue specific. Springer Nature 2023-06-13 Conference or Workshop Item PeerReviewed text en https://repository.londonmet.ac.uk/9263/1/ESHG%20Poster%20Telomere%20Length%20and%20Oxidative%20Stress%20Final.pdf Kidd, Elliot, Meimaridou, Eirini, Walley, Andrew and Fairbrother, Una (2023) Telomere oxidation status (TOS) is correlated with relative telomere length (RTL) across different mouse tissues but not with nicotinamide nucleotide transhydrogenase (Nnt) status. In: ESHG 2023 - 56th European Society of Human Genetics Conference, 10-13th June 2023, Glasgow. https://www.nature.com/articles/s41431-023-01482-x 10.1038/s41431-023-01482-x 10.1038/s41431-023-01482-x |
| spellingShingle | 570 Life sciences; biology Kidd, Elliot Meimaridou, Eirini Walley, Andrew Fairbrother, Una Telomere oxidation status (TOS) is correlated with relative telomere length (RTL) across different mouse tissues but not with nicotinamide nucleotide transhydrogenase (Nnt) status |
| title | Telomere oxidation status (TOS) is correlated with relative telomere length (RTL) across different mouse tissues but not with nicotinamide nucleotide transhydrogenase (Nnt) status |
| title_full | Telomere oxidation status (TOS) is correlated with relative telomere length (RTL) across different mouse tissues but not with nicotinamide nucleotide transhydrogenase (Nnt) status |
| title_fullStr | Telomere oxidation status (TOS) is correlated with relative telomere length (RTL) across different mouse tissues but not with nicotinamide nucleotide transhydrogenase (Nnt) status |
| title_full_unstemmed | Telomere oxidation status (TOS) is correlated with relative telomere length (RTL) across different mouse tissues but not with nicotinamide nucleotide transhydrogenase (Nnt) status |
| title_short | Telomere oxidation status (TOS) is correlated with relative telomere length (RTL) across different mouse tissues but not with nicotinamide nucleotide transhydrogenase (Nnt) status |
| title_sort | telomere oxidation status tos is correlated with relative telomere length rtl across different mouse tissues but not with nicotinamide nucleotide transhydrogenase nnt status |
| topic | 570 Life sciences; biology |
| url | https://repository.londonmet.ac.uk/9263/1/ESHG%20Poster%20Telomere%20Length%20and%20Oxidative%20Stress%20Final.pdf |
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