Evaluation of drug reproductive toxicity and the underlying mechanisms
The potential negative effects of drugs on male fertility are of increasing concern. The effects of drugs on male fertility can be divided into three categories: hormonal effects, sexual dysfunction, and poor semen quality. The negative effect of drugs on male germ and somatic cells may ultimately a...
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| Format: | Book Section |
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Royal Society of Chemistry
2024
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| _version_ | 1824446469505024000 |
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| author | Wu, Sixian Shang, Lijun Xu, Wenming |
| author2 | Anderson, Diana |
| author_facet | Anderson, Diana Wu, Sixian Shang, Lijun Xu, Wenming |
| author_sort | Wu, Sixian |
| collection | LMU |
| description | The potential negative effects of drugs on male fertility are of increasing concern. The effects of drugs on male fertility can be divided into three categories: hormonal effects, sexual dysfunction, and poor semen quality. The negative effect of drugs on male germ and somatic cells may ultimately affect fertility or the ability to produce healthy offspring. In order to enable patients to have offspring while minimizing adverse drug reactions, it is important to obtain optimal information on the relative toxicity of drugs. It is also necessary to explain the mechanism of drug toxicity in drug-induced infertility. Therefore, this chapter will describe the mechanisms involved in male germ cell and somatic cell toxicity and summarize the current advanced techniques for assessing drug toxicity and analysing the mechanism of drug toxicity. |
| first_indexed | 2025-02-19T01:15:39Z |
| format | Book Section |
| id | oai:repository.londonmet.ac.uk:9502 |
| institution | London Metropolitan University |
| last_indexed | 2025-02-19T01:15:39Z |
| publishDate | 2024 |
| publisher | Royal Society of Chemistry |
| record_format | eprints |
| spelling | oai:repository.londonmet.ac.uk:95022024-07-11T08:28:37Z https://repository.londonmet.ac.uk/9502/ Evaluation of drug reproductive toxicity and the underlying mechanisms Wu, Sixian Shang, Lijun Xu, Wenming 610 Medicine & health The potential negative effects of drugs on male fertility are of increasing concern. The effects of drugs on male fertility can be divided into three categories: hormonal effects, sexual dysfunction, and poor semen quality. The negative effect of drugs on male germ and somatic cells may ultimately affect fertility or the ability to produce healthy offspring. In order to enable patients to have offspring while minimizing adverse drug reactions, it is important to obtain optimal information on the relative toxicity of drugs. It is also necessary to explain the mechanism of drug toxicity in drug-induced infertility. Therefore, this chapter will describe the mechanisms involved in male germ cell and somatic cell toxicity and summarize the current advanced techniques for assessing drug toxicity and analysing the mechanism of drug toxicity. Royal Society of Chemistry Anderson, Diana Habas, Khaled 2024-07-01 Book Section PeerReviewed Wu, Sixian, Shang, Lijun and Xu, Wenming (2024) Evaluation of drug reproductive toxicity and the underlying mechanisms. In: Male-mediated developmental toxicity. Issues in toxicology (49). Royal Society of Chemistry, London, pp. 105-122. ISBN 978-1-83916-719-5 https://doi.org/10.1039/bk9781837670192-00105 10.1039/bk9781837670192-00105 10.1039/bk9781837670192-00105 |
| spellingShingle | 610 Medicine & health Wu, Sixian Shang, Lijun Xu, Wenming Evaluation of drug reproductive toxicity and the underlying mechanisms |
| title | Evaluation of drug reproductive toxicity and the underlying mechanisms |
| title_full | Evaluation of drug reproductive toxicity and the underlying mechanisms |
| title_fullStr | Evaluation of drug reproductive toxicity and the underlying mechanisms |
| title_full_unstemmed | Evaluation of drug reproductive toxicity and the underlying mechanisms |
| title_short | Evaluation of drug reproductive toxicity and the underlying mechanisms |
| title_sort | evaluation of drug reproductive toxicity and the underlying mechanisms |
| topic | 610 Medicine & health |
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