Evaluation of drug reproductive toxicity and the underlying mechanisms
The potential negative effects of drugs on male fertility are of increasing concern. The effects of drugs on male fertility can be divided into three categories: hormonal effects, sexual dysfunction, and poor semen quality. The negative effect of drugs on male germ and somatic cells may ultimately a...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Book Section |
| Language: | English |
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Royal Society of Chemistry
2024
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| Subjects: | |
| Online Access: | https://repository.londonmet.ac.uk/9515/3/Book%20Chapter%20Template%20-%20RoyalSociety%20of%20Chemistry--final-SHANG.pdf |
| _version_ | 1824446471114588160 |
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| author | Wu, Sixian Shang, Lijun Xu, Wenming |
| author2 | Anderson, Diana |
| author_facet | Anderson, Diana Wu, Sixian Shang, Lijun Xu, Wenming |
| author_sort | Wu, Sixian |
| collection | LMU |
| description | The potential negative effects of drugs on male fertility are of increasing concern. The effects of drugs on male fertility can be divided into three categories: hormonal effects, sexual dysfunction, and poor semen quality. The negative effect of drugs on male germ and somatic cells may ultimately affect fertility or the ability to produce healthy offspring. In order to enable patients to have offspring while minimizing adverse drug reactions, it is important to obtain optimal information on the relative toxicity of drugs. It is also necessary to explain the mechanism of drug toxicity in drug-induced infertility. Therefore, this chapter will describe the mechanisms involved in male germ cell and somatic cell toxicity and summarize the current advanced techniques for assessing drug toxicity and analysing the mechanism of drug toxicity. |
| first_indexed | 2025-02-19T01:15:41Z |
| format | Book Section |
| id | oai:repository.londonmet.ac.uk:9515 |
| institution | London Metropolitan University |
| language | English |
| last_indexed | 2025-02-19T01:15:41Z |
| publishDate | 2024 |
| publisher | Royal Society of Chemistry |
| record_format | eprints |
| spelling | oai:repository.londonmet.ac.uk:95152024-07-15T13:36:18Z https://repository.londonmet.ac.uk/9515/ Evaluation of drug reproductive toxicity and the underlying mechanisms Wu, Sixian Shang, Lijun Xu, Wenming 540 Chemistry & allied sciences 570 Life sciences; biology The potential negative effects of drugs on male fertility are of increasing concern. The effects of drugs on male fertility can be divided into three categories: hormonal effects, sexual dysfunction, and poor semen quality. The negative effect of drugs on male germ and somatic cells may ultimately affect fertility or the ability to produce healthy offspring. In order to enable patients to have offspring while minimizing adverse drug reactions, it is important to obtain optimal information on the relative toxicity of drugs. It is also necessary to explain the mechanism of drug toxicity in drug-induced infertility. Therefore, this chapter will describe the mechanisms involved in male germ cell and somatic cell toxicity and summarize the current advanced techniques for assessing drug toxicity and analysing the mechanism of drug toxicity. Royal Society of Chemistry Anderson, Diana Habas, Khaled 2024-07-01 Book Section NonPeerReviewed text en https://repository.londonmet.ac.uk/9515/3/Book%20Chapter%20Template%20-%20RoyalSociety%20of%20Chemistry--final-SHANG.pdf Wu, Sixian, Shang, Lijun and Xu, Wenming (2024) Evaluation of drug reproductive toxicity and the underlying mechanisms. In: Male-mediated developmental toxicity (2nd edition). Issues in Toxicology (49). Royal Society of Chemistry, London (UK), pp. 105-122. ISBN Print: 9781839167195; PDF: 9781837670192; EPUB: 9781837670208 https://books.rsc.org/books/edited-volume/2198/chapter-abstract/8031735/Evaluation-of-Drug-Reproductive-Toxicity-and-the?redirectedFrom=PDF 10.1039/BK9781837670192-00105 10.1039/BK9781837670192-00105 |
| spellingShingle | 540 Chemistry & allied sciences 570 Life sciences; biology Wu, Sixian Shang, Lijun Xu, Wenming Evaluation of drug reproductive toxicity and the underlying mechanisms |
| title | Evaluation of drug reproductive toxicity and the underlying mechanisms |
| title_full | Evaluation of drug reproductive toxicity and the underlying mechanisms |
| title_fullStr | Evaluation of drug reproductive toxicity and the underlying mechanisms |
| title_full_unstemmed | Evaluation of drug reproductive toxicity and the underlying mechanisms |
| title_short | Evaluation of drug reproductive toxicity and the underlying mechanisms |
| title_sort | evaluation of drug reproductive toxicity and the underlying mechanisms |
| topic | 540 Chemistry & allied sciences 570 Life sciences; biology |
| url | https://repository.londonmet.ac.uk/9515/3/Book%20Chapter%20Template%20-%20RoyalSociety%20of%20Chemistry--final-SHANG.pdf |
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