Biophysical evidence for conformational change in MHC class I molecules upon peptide binding
MHC class 1 molecules hind peptides of 8-12 amino acids in the endoplasmic reticulum of mammalian cells to present them at the reil surface to cytotoxic T lymphocytes. In crystal structures of the complex, peptides are deeply buried within a binding groove. We have expressed the murim1 class I molec...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1997
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