Biophysical evidence for conformational change in MHC class I molecules upon peptide binding

Biophysical evidence for conformational change in MHC class I molecules upon peptide binding

MHC class 1 molecules hind peptides of 8-12 amino acids in the endoplasmic reticulum of mammalian cells to present them at the reil surface to cytotoxic T lymphocytes. In crystal structures of the complex, peptides are deeply buried within a binding groove. We have expressed the murim1 class I molec...

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Bibliographic Details
Main Authors:	Springer, S, Poring, K, Townsend, A
Format:	Journal article
Language:	English
Published:	1997

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