Effective delivery of volatile biocides employing mesoporous silicates for treating biofilms
Nanoparticulate delivery of biocides has the potential to decrease levels of exposure to non- target organisms, and miminise long-term exposure which can promote the development of resistance. Silica nanoparticles are an ideal vehicle since they are inert, biocompatible, biodegradable, and thermally...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Published: |
Royal Society
2017
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| _version_ | 1797050211970842624 |
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| author | Chan, A Bravo Cadena, M Townley, H Fricker, M Thompson, I |
| author_facet | Chan, A Bravo Cadena, M Townley, H Fricker, M Thompson, I |
| author_sort | Chan, A |
| collection | OXFORD |
| description | Nanoparticulate delivery of biocides has the potential to decrease levels of exposure to non- target organisms, and miminise long-term exposure which can promote the development of resistance. Silica nanoparticles are an ideal vehicle since they are inert, biocompatible, biodegradable, and thermally and chemically stable. Encapsulation of biocides within nanoparticulates can improve their stability, longevity and maximize the biocidal potential of hydrophobic volatile compounds. Herein, we have shown that the plant secondary metabolites allyl isothiocyanate (AIT) and cinnamaldehyde (CNAD) demonstrated increased antimicrobial activity against Escherichia coli in planktonic form, when packaged into mesoporous silica nanoparticles (MSNPs). Furthermore, the biocide loaded nanoparticles showed activity against Pseudomonas aeruginosa biofilms which have inherent resistance to antimicrobial agents. The delivery platform can also be expanded to traditional biocides and other nonconventional antimicrobial agents. |
| first_indexed | 2024-03-06T18:01:49Z |
| format | Journal article |
| id | oxford-uuid:000acead-e819-4d33-8386-2bad19aa8bd1 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T18:01:49Z |
| publishDate | 2017 |
| publisher | Royal Society |
| record_format | dspace |
| spelling | oxford-uuid:000acead-e819-4d33-8386-2bad19aa8bd12022-03-26T08:27:19ZEffective delivery of volatile biocides employing mesoporous silicates for treating biofilmsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:000acead-e819-4d33-8386-2bad19aa8bd1Symplectic Elements at OxfordRoyal Society2017Chan, ABravo Cadena, MTownley, HFricker, MThompson, INanoparticulate delivery of biocides has the potential to decrease levels of exposure to non- target organisms, and miminise long-term exposure which can promote the development of resistance. Silica nanoparticles are an ideal vehicle since they are inert, biocompatible, biodegradable, and thermally and chemically stable. Encapsulation of biocides within nanoparticulates can improve their stability, longevity and maximize the biocidal potential of hydrophobic volatile compounds. Herein, we have shown that the plant secondary metabolites allyl isothiocyanate (AIT) and cinnamaldehyde (CNAD) demonstrated increased antimicrobial activity against Escherichia coli in planktonic form, when packaged into mesoporous silica nanoparticles (MSNPs). Furthermore, the biocide loaded nanoparticles showed activity against Pseudomonas aeruginosa biofilms which have inherent resistance to antimicrobial agents. The delivery platform can also be expanded to traditional biocides and other nonconventional antimicrobial agents. |
| spellingShingle | Chan, A Bravo Cadena, M Townley, H Fricker, M Thompson, I Effective delivery of volatile biocides employing mesoporous silicates for treating biofilms |
| title | Effective delivery of volatile biocides employing mesoporous silicates for treating biofilms |
| title_full | Effective delivery of volatile biocides employing mesoporous silicates for treating biofilms |
| title_fullStr | Effective delivery of volatile biocides employing mesoporous silicates for treating biofilms |
| title_full_unstemmed | Effective delivery of volatile biocides employing mesoporous silicates for treating biofilms |
| title_short | Effective delivery of volatile biocides employing mesoporous silicates for treating biofilms |
| title_sort | effective delivery of volatile biocides employing mesoporous silicates for treating biofilms |
| work_keys_str_mv | AT chana effectivedeliveryofvolatilebiocidesemployingmesoporoussilicatesfortreatingbiofilms AT bravocadenam effectivedeliveryofvolatilebiocidesemployingmesoporoussilicatesfortreatingbiofilms AT townleyh effectivedeliveryofvolatilebiocidesemployingmesoporoussilicatesfortreatingbiofilms AT frickerm effectivedeliveryofvolatilebiocidesemployingmesoporoussilicatesfortreatingbiofilms AT thompsoni effectivedeliveryofvolatilebiocidesemployingmesoporoussilicatesfortreatingbiofilms |