Interactions between Neisseria meningitidis and the complement system.
Meningococcal infection remains a worldwide health problem, and understanding the mechanisms by which Neisseria meningitidis evades host innate and acquired immunity is crucial. The complement system is vital for protecting individuals against N. meningitidis. However, this pathogen has evolved seve...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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2007
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| _version_ | 1797050216829943808 |
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| author | Schneider, M Exley, R Ram, S Sim, R Tang, C |
| author_facet | Schneider, M Exley, R Ram, S Sim, R Tang, C |
| author_sort | Schneider, M |
| collection | OXFORD |
| description | Meningococcal infection remains a worldwide health problem, and understanding the mechanisms by which Neisseria meningitidis evades host innate and acquired immunity is crucial. The complement system is vital for protecting individuals against N. meningitidis. However, this pathogen has evolved several mechanisms to avoid killing by human complement. Bacterial structures such as polysaccharide capsule and those which mimic or bind host molecules function to prevent complement-mediated lysis and phagocytosis. This review provides an update on the recent findings on the diverse mechanisms by which N. meningitidis avoids complement-mediated killing, and how polymorphisms in genes encoding human complement proteins affect susceptibility to this important human pathogen. |
| first_indexed | 2024-03-06T18:01:54Z |
| format | Journal article |
| id | oxford-uuid:000f5456-888b-48ea-b1ab-58b59a81adf0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:01:54Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:000f5456-888b-48ea-b1ab-58b59a81adf02022-03-26T08:27:33ZInteractions between Neisseria meningitidis and the complement system.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:000f5456-888b-48ea-b1ab-58b59a81adf0EnglishSymplectic Elements at Oxford2007Schneider, MExley, RRam, SSim, RTang, CMeningococcal infection remains a worldwide health problem, and understanding the mechanisms by which Neisseria meningitidis evades host innate and acquired immunity is crucial. The complement system is vital for protecting individuals against N. meningitidis. However, this pathogen has evolved several mechanisms to avoid killing by human complement. Bacterial structures such as polysaccharide capsule and those which mimic or bind host molecules function to prevent complement-mediated lysis and phagocytosis. This review provides an update on the recent findings on the diverse mechanisms by which N. meningitidis avoids complement-mediated killing, and how polymorphisms in genes encoding human complement proteins affect susceptibility to this important human pathogen. |
| spellingShingle | Schneider, M Exley, R Ram, S Sim, R Tang, C Interactions between Neisseria meningitidis and the complement system. |
| title | Interactions between Neisseria meningitidis and the complement system. |
| title_full | Interactions between Neisseria meningitidis and the complement system. |
| title_fullStr | Interactions between Neisseria meningitidis and the complement system. |
| title_full_unstemmed | Interactions between Neisseria meningitidis and the complement system. |
| title_short | Interactions between Neisseria meningitidis and the complement system. |
| title_sort | interactions between neisseria meningitidis and the complement system |
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