Herpes simplex virus type 2 seropositivity among urban adults in Africa: results from two cross-sectional surveys in Addis Ababa, Ethiopia.
BACKGROUND: Although several surveys investigating the epidemiology of herpes simplex virus type 2 (HSV-2) infection using type-specific immunologic assays have been carried out in Africa, none has examined the risk factors for HSV-2 infection in a representative sample from an urban adult populati...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2002
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| _version_ | 1797050237425025024 |
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| author | Mihret, W Rinke de Wit, T Petros, B Mekonnen, Y Tsegaye, A Wolday, D Beyene, A Aklilu, M Sanders, E Fontanet, A |
| author_facet | Mihret, W Rinke de Wit, T Petros, B Mekonnen, Y Tsegaye, A Wolday, D Beyene, A Aklilu, M Sanders, E Fontanet, A |
| author_sort | Mihret, W |
| collection | OXFORD |
| description | BACKGROUND: Although several surveys investigating the epidemiology of herpes simplex virus type 2 (HSV-2) infection using type-specific immunologic assays have been carried out in Africa, none has examined the risk factors for HSV-2 infection in a representative sample from an urban adult population. GOALS: To estimate the prevalence of HSV-2 infection in the adult population of Addis Ababa, Ethiopia, and to identify risk factors for HSV-2 infection. STUDY DESIGN: Two cross-sectional surveys, one community-based (June to September 1996, n = 506) and one factory-based (February to November 1997, n = 657), were conducted. Samples were tested for HSV-2 immunoglobulin G antibodies using type-specific enzyme-linked immunoassays (ELISA). RESULTS: In the community-based survey, HSV-2 prevalence increased with age until 25 years, then leveled off at 50% in both genders. The same independent predictors of HSV-2 infection were identified in both genders: older age, higher lifetime number of sexual partners, positive HIV serology, and positive Treponema pallidum hemagglutination serology. CONCLUSIONS: This study confirmed the high prevalence of HSV-2 infection among adults in an African urban population and its association with HIV infection. Prevention of HSV-2 and other sexually transmitted infections through partner reduction and condom use should be encouraged. |
| first_indexed | 2024-03-06T18:02:12Z |
| format | Journal article |
| id | oxford-uuid:0029dcd6-3927-47dd-b1e6-42b90f731180 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:02:12Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:0029dcd6-3927-47dd-b1e6-42b90f7311802022-03-26T08:28:05ZHerpes simplex virus type 2 seropositivity among urban adults in Africa: results from two cross-sectional surveys in Addis Ababa, Ethiopia.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:0029dcd6-3927-47dd-b1e6-42b90f731180EnglishSymplectic Elements at Oxford2002Mihret, WRinke de Wit, TPetros, BMekonnen, YTsegaye, AWolday, DBeyene, AAklilu, MSanders, EFontanet, A BACKGROUND: Although several surveys investigating the epidemiology of herpes simplex virus type 2 (HSV-2) infection using type-specific immunologic assays have been carried out in Africa, none has examined the risk factors for HSV-2 infection in a representative sample from an urban adult population. GOALS: To estimate the prevalence of HSV-2 infection in the adult population of Addis Ababa, Ethiopia, and to identify risk factors for HSV-2 infection. STUDY DESIGN: Two cross-sectional surveys, one community-based (June to September 1996, n = 506) and one factory-based (February to November 1997, n = 657), were conducted. Samples were tested for HSV-2 immunoglobulin G antibodies using type-specific enzyme-linked immunoassays (ELISA). RESULTS: In the community-based survey, HSV-2 prevalence increased with age until 25 years, then leveled off at 50% in both genders. The same independent predictors of HSV-2 infection were identified in both genders: older age, higher lifetime number of sexual partners, positive HIV serology, and positive Treponema pallidum hemagglutination serology. CONCLUSIONS: This study confirmed the high prevalence of HSV-2 infection among adults in an African urban population and its association with HIV infection. Prevention of HSV-2 and other sexually transmitted infections through partner reduction and condom use should be encouraged. |
| spellingShingle | Mihret, W Rinke de Wit, T Petros, B Mekonnen, Y Tsegaye, A Wolday, D Beyene, A Aklilu, M Sanders, E Fontanet, A Herpes simplex virus type 2 seropositivity among urban adults in Africa: results from two cross-sectional surveys in Addis Ababa, Ethiopia. |
| title | Herpes simplex virus type 2 seropositivity among urban adults in Africa: results from two cross-sectional surveys in Addis Ababa, Ethiopia. |
| title_full | Herpes simplex virus type 2 seropositivity among urban adults in Africa: results from two cross-sectional surveys in Addis Ababa, Ethiopia. |
| title_fullStr | Herpes simplex virus type 2 seropositivity among urban adults in Africa: results from two cross-sectional surveys in Addis Ababa, Ethiopia. |
| title_full_unstemmed | Herpes simplex virus type 2 seropositivity among urban adults in Africa: results from two cross-sectional surveys in Addis Ababa, Ethiopia. |
| title_short | Herpes simplex virus type 2 seropositivity among urban adults in Africa: results from two cross-sectional surveys in Addis Ababa, Ethiopia. |
| title_sort | herpes simplex virus type 2 seropositivity among urban adults in africa results from two cross sectional surveys in addis ababa ethiopia |
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