Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer.

Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer.

Genome-wide association studies (GWAS) have identified 14 tagging single nucleotide polymorphisms (tagSNPs) that are associated with the risk of colorectal cancer (CRC), and several of these tagSNPs are near bone morphogenetic protein (BMP) pathway loci. The penalty of multiple testing implicit in G...

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Main Authors: Tomlinson, I, Carvajal-Carmona, L, Dobbins, SE, Tenesa, A, Jones, A, Howarth, K, Palles, C, Broderick, P, Jaeger, E, Farrington, S, Lewis, A, Prendergast, J, Pittman, A, Theodoratou, E, Olver, B, Walker, M, Penegar, S, Barclay, E, Whiffin, N, Martin, L, Ballereau, S, Lloyd, A, Gorman, M, Lubbe, S, Howie, B, Marchini, J, Ruiz-Ponte, C, Fernandez-Rozadilla, C, Castells, A, Carracedo, A, Castellvi-Bel, S, Duggan, D, Conti, D, Cazier, J, Campbell, H, Sieber, O, Lipton, L, Gibbs, P, Martin, N, Montgomery, G, Young, J, Baird, P, Gallinger, S, Newcomb, P, Hopper, J, Jenkins, M, Aaltonen, L, Kerr, D, Cheadle, J, Pharoah, P, Casey, G, Houlston, R, Dunlop, MG
Format: Journal article
Language:English
Published: Public Library of Science 2011

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