In vitro selection of macrocyclic peptide inhibitors containing cyclic γ2,4-amino acids targeting the SARS-CoV-2 main protease

In vitro selection of macrocyclic peptide inhibitors containing cyclic γ2,4-amino acids targeting the SARS-CoV-2 main protease

γ-Amino acids can play important roles in the biological activities of natural products; however, ribosomal incorporation of γ-amino acids into peptides is challenging. Here we report how a selection campaign employing a non-canonical peptide library containing cyclic γ2,4-amino acids (cγAAs) result...

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Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Miura, T, Malla, TR, Owen, D, Tumber, A, Brewitz, L, McDonough, M, Salah, E, Terasaka, N, Katoh, T, Lukacik, P, Strain-Damerell, C, Mikolajek, H, Walsh, M, Kawamura, A, Schofield, C, Suga, H
Μορφή: Journal article
Γλώσσα:English
Έκδοση: Springer Nature 2023

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