Aggrecanases and TIMP-3 in osteoarthritis: structure, function and in vivo challenges

Aggrecanases and TIMP-3 in osteoarthritis: structure, function and in vivo challenges

書目詳細資料
主要作者:	Nagase, H
格式:	Journal article
出版:	2009

相似書籍

TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5).
由: Kashiwagi, M, et al.
出版: (2001)

Calcium pentosan polysulfate is a multi-functional aggrecanase inhibitor that enhances interaction with endogenous TIMP-3 in cartilage
由: Troeberg, L, et al.
出版: (2009)

TIMP-3 inhibits aggrecanase-mediated glycosaminoglycan release from cartilage explants stimulated by catabolic factors.
由: Gendron, C, et al.
出版: (2003)

Calcium pentosan polysulfate increases affinity between aggrecanases (ADAMTS-4 and-5) and TIMP-3 by a conformational change
由: Troeberg, L, et al.
出版: (2010)

Aggrecanase-selective tissue inhibitor of metalloproteinase-3 (TIMP3) protects articular cartilage in a surgical mouse model of osteoarthritis
由: Hiroyuki Nakamura, et al.
出版: (2020-06-01)

Aggrecanases in cartilage matrix breakdown
由: Nagase, H
出版: (2001)

Aggrecanases and cartilage matrix degradation.
由: Nagase, H, et al.
出版: (2003)

Elucidating the function of non catalytic domains of collagenases and aggrecanases.
由: Nagase, H, et al.
出版: (2008)

Elucidating the function of non catalytic domains of collagenases and aggrecanases
由: Nagase, H, et al.
出版: (2008)

Tenascin-C fragments induce aggrecanase activity in cartilage
由: Sofat, N, et al.
出版: (2008)

Arylsulfonamide inhibitors of aggrecanases as potential therapeutic agents for osteoarthritis: synthesis and biological evaluation.
由: Nuti, E, et al.
出版: (2013)

Genetic variation of aggrecanase-2 (ADAMTS5) in susceptibility to osteoarthritis
由: Xindie Zhou, et al.
出版: (2019-01-01)

Structure and function of matrix metalloproteinases and TIMPs.
由: Nagase, H, et al.
出版: (2006)

Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases.
由: Troeberg, L, et al.
出版: (2008)

Collagenases and aggrecanases: understanding the role of non-catalytic domains in cartilage matrix breakdown
由: Nagase, H, et al.
出版: (2005)

The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity.
由: Brew, K, et al.
出版: (2010)

Microvesicles shed by oligodendroglioma cells and rheumatoid synovial fibroblasts contain aggrecanase activity
由: Lo Cicero, A, et al.
出版: (2012)

Microvesicles shed by oligodendroglioma cells and rheumatoid synovial fibroblasts contain aggrecanase activity.
由: Lo Cicero, A, et al.
出版: (2012)

Aggrecanase-2 inhibitors based on the acylthiosemicarbazide zinc-binding group.
由: Maingot, L, et al.
出版: (2013)

Generation of Tamoxifen inducible mice to express hTIMP-3 in articular chondrocytes to block degradation of cartilage in osteoarthritis
由: Lo Cascio, L, et al.
出版: (2012)

Purification of MMPs and TIMPs.
由: Shimokawa, K, et al.
出版: (2010)

Purification of MMPs and TIMPs.
由: Shimokawa, K, et al.
出版: (2001)

LRP-dependent and -independent internalisation of TIMP-3
由: Scilabra, S, et al.
出版: (2011)

Analysis of TIMP expression and activity.
由: Troeberg, L, et al.
出版: (2007)

Desumoylation of aggrecan and collagen II facilitates degradation via aggrecanases in IL-1β-mediated osteoarthritis
由: Zhu B, et al.
出版: (2019-07-01)

E. coli expression of TIMP-4 and comparative kinetic studies with TIMP-1 and TIMP-2: insights into the interactions of TIMPs and matrix metalloproteinase 2 (gelatinase A).
由: Troeberg, L, et al.
出版: (2002)

Proteolytic fragments of fibronectin containing the type III-13 and III-14 repeats induce aggrecanase activity in cartilage
由: Sofat, N, et al.
出版: (2006)

Substrate conformation modulates aggrecanase (ADAMTS-4) affinity and sequence specificity. Suggestion of a common topological specificity for functionally diverse proteases.
由: Lauer-Fields, J, et al.
出版: (2007)

Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) - Physiological roles and structural basis of MMP inhibition by TIMP-1
由: Nagase, H, et al.
出版: (2000)

Characterisation of N-TIMP-3 mutants that selectively inhibit the ADAMTSs
由: Lim, N, et al.
出版: (2009)

Endocytic pathways of TIMP-3 and its N-terminal inhibitory domain
由: Scilabra, S, et al.
出版: (2009)

TIMP-3 inhibits the procollagen N-proteinase ADAMTS-2.
由: Wang, WM, et al.
出版: (2006)

Designing TIMP (tissue inhibitor of metalloproteinases) variants that are selective metalloproteinase inhibitors.
由: Nagase, H, et al.
出版: (2003)

Roles of metalloproteinase-3 and aggrecanase 1 and 2 in aggrecan cleavage during human meniscus degeneration
由: Naoki Ishiguro, et al.
出版: (2009-10-01)

Structural features of the reprolysin atrolysin C and tissue inhibitors of metalloproteinases (TIMPs) interaction.
由: Pinto, A, et al.
出版: (2006)

Mannosamine inhibits aggrecanase-mediated degradation of the mechanically functional portion of proteoglycans and of the physical properties of articular cartilage
由: Patwari, Parth, 1972-
出版: (2014)

Screening for selective aggrecanase substrates to detect early proteolytic events in cartilage degradation
由: Fowkes, M, et al.
出版: (2018)

Borrelia burgdorferi Aggrecanase Activity: More Evidence for Persistent Infection in Lyme Disease.
由: Raphael B. Stricker, et al.
出版: (2013-08-01)

THE TYPE III 8-10 REPEATS OF FIBRONECTIN INDUCE AGGRECANASE ACTIVITY VIA ALPHA5BETA1 INTEGRIN AND THE TYPE III 13-14 REPEATS ACT VIA TLR 4 RECEPTORS
由: Sofat, N, et al.
出版: (2009)

The type III 8-10 repeats of fibronectin induce aggrecanase activity via alpha(5)beta(1) integrin and type III 13-14 repeats act via TLR 4 receptors
由: Sofat, N, et al.
出版: (2009)