Aggrecanases and TIMP-3 in osteoarthritis: structure, function and in vivo challenges

Eitemau Tebyg

• TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5).
  gan: Kashiwagi, M, et al.
  Cyhoeddwyd: (2001)
• Calcium pentosan polysulfate is a multi-functional aggrecanase inhibitor that enhances interaction with endogenous TIMP-3 in cartilage
  gan: Troeberg, L, et al.
  Cyhoeddwyd: (2009)
• TIMP-3 inhibits aggrecanase-mediated glycosaminoglycan release from cartilage explants stimulated by catabolic factors.
  gan: Gendron, C, et al.
  Cyhoeddwyd: (2003)
• Calcium pentosan polysulfate increases affinity between aggrecanases (ADAMTS-4 and-5) and TIMP-3 by a conformational change
  gan: Troeberg, L, et al.
  Cyhoeddwyd: (2010)
• Aggrecanase-selective tissue inhibitor of metalloproteinase-3 (TIMP3) protects articular cartilage in a surgical mouse model of osteoarthritis
  gan: Hiroyuki Nakamura, et al.
  Cyhoeddwyd: (2020-06-01)