Direct analysis of enzyme-catalyzed DNA demethylation.

Direct analysis of enzyme-catalyzed DNA demethylation.

N/O-methylation of DNA can be cytotoxic and mutagenic; therefore, enzymes that reverse DNA methylation are essential for organism survival. Several 2-oxoglutarate-dependent oxygenases and methyltransferases that remove a methyl group from a methylated DNA base have been identified. Studies of their...

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Bibliographic Details
Main Authors:	Karkhanina, A, Mecinović, J, Musheev, M, Krylova, S, Petrov, A, Hewitson, K, Flashman, E, Schofield, C, Krylov, SN
Format:	Journal article
Language:	English
Published:	2009

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