A glycoconjugate antigen based on the recognition motif of a broadly neutralizing human immunodeficiency virus antibody, 2G12, is immunogenic but elicits antibodies unable to bind to the self glycans of gp120.

A glycoconjugate antigen based on the recognition motif of a broadly neutralizing human immunodeficiency virus antibody, 2G12, is immunogenic but elicits antibodies unable to bind to the self glycans of gp120.

The glycan shield of human immunodeficiency virus type 1 (HIV-1) gp120 contributes to viral evasion from humoral immune responses. However, the shield is recognized by the HIV-1 broadly neutralizing antibody (Ab), 2G12, at a relatively conserved cluster of oligomannose glycans. The discovery of 2G12...

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Bibliografiske detaljer
Main Authors:	Astronomo, R, Lee, H, Scanlan, C, Pantophlet, R, Huang, C, Wilson, I, Blixt, O, Dwek, R, Wong, C, Burton, DR
Format:	Journal article
Sprog:	English
Udgivet:	2008

Lignende værker

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af: Scanlan, C, et al.
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af: Rudd, P, et al.
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af: Mata-Fink, Jordi, et al.
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af: Evan M. Cale, et al.
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Primary isolates of human immunodeficiency virus type 1 are relatively resistant to neutralization by monoclonal antibodies to gp120, and their neutralization is not predicted by studies with monomeric gp120.
af: Moore, J, et al.
Udgivet: (1995)

Glycan modifications to the gp120 immunogens used in the RV144 vaccine trial improve binding to broadly neutralizing antibodies.
af: Rachel C Doran, et al.
Udgivet: (2018-01-01)

Hyperglycosylated resurfaced stabilized GP120 core as an immunogen elicits antibodies targeted at the CD4-binding site
af: Dai K, et al.
Udgivet: (2012-09-01)

Envelope glycans of immunodeficiency virions are almost entirely oligomannose antigens
af: Doores, K, et al.
Udgivet: (2010)

Monoclonal antibodies to HIV-1 gp120: a request.
af: Moore, J, et al.
Udgivet: (1993)

Glycan microheterogeneity at the PGT135 antibody recognition site on HIV-1 gp120 reveals a molecular mechanism for neutralization resistance.
af: Pritchard, L, et al.
Udgivet: (2015)

Probing the structure of the human immunodeficiency virus surface glycoprotein gp120 with a panel of monoclonal antibodies.
af: Moore, J, et al.
Udgivet: (1994)

Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation
af: Tongqing Zhou, et al.
Udgivet: (2017-04-01)

Antibody and HIV-1 gp120 recognition of CD4 undermines the concept of mimicry between antibodies and receptors.
af: Davis, S, et al.
Udgivet: (1992)

Antibodies to the CD4-binding site of HIV-1 gp120 suppress gp120-specific CD4 T cell response while enhancing antibody response
af: Hioe Catarina E, et al.
Udgivet: (2008-07-01)

The carbohydrate epitope of the neutralizing anti-HIV-1 antibody 2G12.
af: Scanlan, C, et al.
Udgivet: (2003)

Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans.
af: Jean-Philippe Julien, et al.
Udgivet: (2013-01-01)

Polysaccharide mimicry of the epitope of the broadly neutralizing anti-HIV antibody, 2G12, induces enhanced antibody responses to self oligomannose glycans.
af: Dunlop, D, et al.
Udgivet: (2010)

An aptamer that neutralizes R5 strains of HIV-1 binds to core residues of gp120 in the CCR5 binding site
af: Cohen, C, et al.
Udgivet: (2008)

Improving immunogenicity of HIV-1 envelope gp120 by glycan removal and immune complex formation
af: Kumar R, et al.
Udgivet: (2012-09-01)

Myomedin replicas of gp120 V3 loop glycan epitopes recognized by PGT121 and PGT126 antibodies as non-cognate antigens for stimulation of HIV-1 broadly neutralizing antibodies
af: Veronika Daniel Lišková, et al.
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The influence of N-linked glycans on the molecular dynamics of the HIV-1 gp120 V3 loop.
af: Natasha T Wood, et al.
Udgivet: (2013-01-01)

The recognition of chimeras of rat and human CD4 by HIV-1 gp120 and by monoclonal antibodies.
af: Davis, S, et al.
Udgivet: (1993)

Holes in the Glycan Shield of the Native HIV Envelope Are a Target of Trimer-Elicited Neutralizing Antibodies
af: McCoy, Laura E., et al.
Udgivet: (2016)

Allosteric modulation of the HIV-1 gp120-gp41 association site by adjacent gp120 variable region 1 (V1) N-glycans linked to neutralization sensitivity.
af: Heidi E Drummer, et al.
Udgivet: (2013-01-01)

Inhibition of mammalian glycan biosynthesis produces non-self antigens for a broadly neutralising, HIV-1 specific antibody.
af: Scanlan, C, et al.
Udgivet: (2007)

Glycan repositioning of influenza hemagglutinin stem facilitates the elicitation of protective cross-group antibody responses
af: Seyhan Boyoglu-Barnum, et al.
Udgivet: (2020-02-01)

Oligomannose Glycopeptide Conjugates Elicit Antibodies Targeting the Glycan Core Rather than Its Extremities
af: Dung N. Nguyen, et al.
Udgivet: (2019-02-01)

DNA display of glycoconjugates to emulate oligomeric interactions of glycans
af: Alexandre Novoa, et al.
Udgivet: (2015-05-01)

Neutralization of human immunodeficiency virus type 1 by antibody to gp120 is determined primarily by occupancy of sites on the virion irrespective of epitope specificity.
af: Parren, P, et al.
Udgivet: (1998)

Fusion Complexes and CD4-independent gp120s for the Induction of HIV-1 Neutralizing Antibodies
af: Lopalco L, et al.
Udgivet: (2005-12-01)

Heterologous protection elicited by candidate monomeric recombinant HIV-1 gp120 vaccine in the absence of cross neutralising antibodies in a macaque model
af: Page Mark, et al.
Udgivet: (2012-07-01)

Vaccine with bacterium‐like particles displaying HIV‐1 gp120 trimer elicits specific mucosal responses and neutralizing antibodies in rhesus macaques
af: Huaiyu Wang, et al.
Udgivet: (2022-07-01)

Neutralizing antibodies to human immunodeficiency virus type-1 gp120 induce envelope glycoprotein subunit dissociation.
af: Poignard, P, et al.
Udgivet: (1996)

Structure and Recognition of a Novel HIV-1 gp120-gp41 Interface Antibody that Caused MPER Exposure through Viral Escape.
af: Constantinos Kurt Wibmer, et al.
Udgivet: (2017-01-01)

Deletion of the highly conserved N-glycan at Asn260 of HIV-1 gp120 affects folding and lysosomal degradation of gp120, and results in loss of viral infectivity.
af: Leen Mathys, et al.
Udgivet: (2014-01-01)

Correction: Deletion of the Highly Conserved -Glycan at Asn260 of HIV-1 gp120 Affects Folding and Lysosomal Degradation of gp120, and Results in Loss of Viral Infectivity.
Udgivet: (2014-01-01)

Eliciting broadly neutralizing antibodies against HIV-1 that target gp41 MPER
af: Han D, et al.
Udgivet: (2012-09-01)

Correction: Deletion of the Highly Conserved N-Glycan at Asn260 of HIV-1 gp120 Affects Folding and Lysosomal Degradation of gp120, and Results in Loss of Viral Infectivity
Udgivet: (2014-01-01)

Identification and characterization of a broadly cross-reactive HIV-1 human monoclonal antibody that binds to both gp120 and gp41.
af: Mei-Yun Zhang, et al.
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Hidden Lineage Complexity of Glycan-Dependent HIV-1 Broadly Neutralizing Antibodies Uncovered by Digital Panning and Native-Like gp140 Trimer
af: Linling He, et al.
Udgivet: (2017-08-01)