A glycoconjugate antigen based on the recognition motif of a broadly neutralizing human immunodeficiency virus antibody, 2G12, is immunogenic but elicits antibodies unable to bind to the self glycans of gp120.

A glycoconjugate antigen based on the recognition motif of a broadly neutralizing human immunodeficiency virus antibody, 2G12, is immunogenic but elicits antibodies unable to bind to the self glycans of gp120.

The glycan shield of human immunodeficiency virus type 1 (HIV-1) gp120 contributes to viral evasion from humoral immune responses. However, the shield is recognized by the HIV-1 broadly neutralizing antibody (Ab), 2G12, at a relatively conserved cluster of oligomannose glycans. The discovery of 2G12...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Astronomo, R, Lee, H, Scanlan, C, Pantophlet, R, Huang, C, Wilson, I, Blixt, O, Dwek, R, Wong, C, Burton, DR
Формат:	Journal article
Хэл сонгох:	English
Хэвлэсэн:	2008

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-н: Scanlan, C, зэрэг
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-н: Rudd, P, зэрэг
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-н: Evan M. Cale, зэрэг
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Primary isolates of human immunodeficiency virus type 1 are relatively resistant to neutralization by monoclonal antibodies to gp120, and their neutralization is not predicted by studies with monomeric gp120.
-н: Moore, J, зэрэг
Хэвлэсэн: (1995)

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-н: Rachel C Doran, зэрэг
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-н: Dai K, зэрэг
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Envelope glycans of immunodeficiency virions are almost entirely oligomannose antigens
-н: Doores, K, зэрэг
Хэвлэсэн: (2010)

Monoclonal antibodies to HIV-1 gp120: a request.
-н: Moore, J, зэрэг
Хэвлэсэн: (1993)

Glycan microheterogeneity at the PGT135 antibody recognition site on HIV-1 gp120 reveals a molecular mechanism for neutralization resistance.
-н: Pritchard, L, зэрэг
Хэвлэсэн: (2015)

Probing the structure of the human immunodeficiency virus surface glycoprotein gp120 with a panel of monoclonal antibodies.
-н: Moore, J, зэрэг
Хэвлэсэн: (1994)

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Antibody and HIV-1 gp120 recognition of CD4 undermines the concept of mimicry between antibodies and receptors.
-н: Davis, S, зэрэг
Хэвлэсэн: (1992)

Antibodies to the CD4-binding site of HIV-1 gp120 suppress gp120-specific CD4 T cell response while enhancing antibody response
-н: Hioe Catarina E, зэрэг
Хэвлэсэн: (2008-07-01)

The carbohydrate epitope of the neutralizing anti-HIV-1 antibody 2G12.
-н: Scanlan, C, зэрэг
Хэвлэсэн: (2003)

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-н: Jean-Philippe Julien, зэрэг
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Polysaccharide mimicry of the epitope of the broadly neutralizing anti-HIV antibody, 2G12, induces enhanced antibody responses to self oligomannose glycans.
-н: Dunlop, D, зэрэг
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An aptamer that neutralizes R5 strains of HIV-1 binds to core residues of gp120 in the CCR5 binding site
-н: Cohen, C, зэрэг
Хэвлэсэн: (2008)

Improving immunogenicity of HIV-1 envelope gp120 by glycan removal and immune complex formation
-н: Kumar R, зэрэг
Хэвлэсэн: (2012-09-01)

Myomedin replicas of gp120 V3 loop glycan epitopes recognized by PGT121 and PGT126 antibodies as non-cognate antigens for stimulation of HIV-1 broadly neutralizing antibodies
-н: Veronika Daniel Lišková, зэрэг
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The influence of N-linked glycans on the molecular dynamics of the HIV-1 gp120 V3 loop.
-н: Natasha T Wood, зэрэг
Хэвлэсэн: (2013-01-01)

The recognition of chimeras of rat and human CD4 by HIV-1 gp120 and by monoclonal antibodies.
-н: Davis, S, зэрэг
Хэвлэсэн: (1993)

Holes in the Glycan Shield of the Native HIV Envelope Are a Target of Trimer-Elicited Neutralizing Antibodies
-н: McCoy, Laura E., зэрэг
Хэвлэсэн: (2016)

Allosteric modulation of the HIV-1 gp120-gp41 association site by adjacent gp120 variable region 1 (V1) N-glycans linked to neutralization sensitivity.
-н: Heidi E Drummer, зэрэг
Хэвлэсэн: (2013-01-01)

Inhibition of mammalian glycan biosynthesis produces non-self antigens for a broadly neutralising, HIV-1 specific antibody.
-н: Scanlan, C, зэрэг
Хэвлэсэн: (2007)

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-н: Seyhan Boyoglu-Barnum, зэрэг
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-н: Dung N. Nguyen, зэрэг
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DNA display of glycoconjugates to emulate oligomeric interactions of glycans
-н: Alexandre Novoa, зэрэг
Хэвлэсэн: (2015-05-01)

Neutralization of human immunodeficiency virus type 1 by antibody to gp120 is determined primarily by occupancy of sites on the virion irrespective of epitope specificity.
-н: Parren, P, зэрэг
Хэвлэсэн: (1998)

Fusion Complexes and CD4-independent gp120s for the Induction of HIV-1 Neutralizing Antibodies
-н: Lopalco L, зэрэг
Хэвлэсэн: (2005-12-01)

Heterologous protection elicited by candidate monomeric recombinant HIV-1 gp120 vaccine in the absence of cross neutralising antibodies in a macaque model
-н: Page Mark, зэрэг
Хэвлэсэн: (2012-07-01)

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Neutralizing antibodies to human immunodeficiency virus type-1 gp120 induce envelope glycoprotein subunit dissociation.
-н: Poignard, P, зэрэг
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Structure and Recognition of a Novel HIV-1 gp120-gp41 Interface Antibody that Caused MPER Exposure through Viral Escape.
-н: Constantinos Kurt Wibmer, зэрэг
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