Cell-surface IL-7 receptor expression facilitates the purification of FOXP3(+) regulatory T cells.
FOXP3+ regulatory T (Treg) cells have crucial roles in maintaining self-tolerance and modulating adaptive immune responses. Functional studies of Treg cells have been hampered by a lack of suitable cell-surface markers that specifically enable their purification without contamination by non-regulato...
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| Format: | Journal article |
| Language: | English |
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2006
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| _version_ | 1797050296183029760 |
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| author | Banham, A |
| author_facet | Banham, A |
| author_sort | Banham, A |
| collection | OXFORD |
| description | FOXP3+ regulatory T (Treg) cells have crucial roles in maintaining self-tolerance and modulating adaptive immune responses. Functional studies of Treg cells have been hampered by a lack of suitable cell-surface markers that specifically enable their purification without contamination by non-regulatory CD25+ effector T cells. Two recent studies have demonstrated that downregulation of the interleukin-7 receptor (CD127) distinguishes Treg cells from activated T cells, facilitating both Treg-cell purification and their functional characterization in human diseases. CD127 uniquely enables the purification of FOXP3+ Treg cells and, potentially, also "adaptive" regulatory T-cell subsets from the CD4+CD25- T-cell population. |
| first_indexed | 2024-03-06T18:03:04Z |
| format | Journal article |
| id | oxford-uuid:007b511b-f9c5-40eb-b1cc-3fb09dd976d2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:03:04Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:007b511b-f9c5-40eb-b1cc-3fb09dd976d22022-03-26T08:29:44ZCell-surface IL-7 receptor expression facilitates the purification of FOXP3(+) regulatory T cells.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:007b511b-f9c5-40eb-b1cc-3fb09dd976d2EnglishSymplectic Elements at Oxford2006Banham, AFOXP3+ regulatory T (Treg) cells have crucial roles in maintaining self-tolerance and modulating adaptive immune responses. Functional studies of Treg cells have been hampered by a lack of suitable cell-surface markers that specifically enable their purification without contamination by non-regulatory CD25+ effector T cells. Two recent studies have demonstrated that downregulation of the interleukin-7 receptor (CD127) distinguishes Treg cells from activated T cells, facilitating both Treg-cell purification and their functional characterization in human diseases. CD127 uniquely enables the purification of FOXP3+ Treg cells and, potentially, also "adaptive" regulatory T-cell subsets from the CD4+CD25- T-cell population. |
| spellingShingle | Banham, A Cell-surface IL-7 receptor expression facilitates the purification of FOXP3(+) regulatory T cells. |
| title | Cell-surface IL-7 receptor expression facilitates the purification of FOXP3(+) regulatory T cells. |
| title_full | Cell-surface IL-7 receptor expression facilitates the purification of FOXP3(+) regulatory T cells. |
| title_fullStr | Cell-surface IL-7 receptor expression facilitates the purification of FOXP3(+) regulatory T cells. |
| title_full_unstemmed | Cell-surface IL-7 receptor expression facilitates the purification of FOXP3(+) regulatory T cells. |
| title_short | Cell-surface IL-7 receptor expression facilitates the purification of FOXP3(+) regulatory T cells. |
| title_sort | cell surface il 7 receptor expression facilitates the purification of foxp3 regulatory t cells |
| work_keys_str_mv | AT banhama cellsurfaceil7receptorexpressionfacilitatesthepurificationoffoxp3regulatorytcells |