Structural and kinetic basis for heightened immunogenicity of T cell vaccines.

Analogue peptides with enhanced binding affinity to major histocompatibility class (MHC) I molecules are currently being used in cancer patients to elicit stronger T cell responses. However, it remains unclear as to how alterations of anchor residues may affect T cell receptor (TCR) recognition. We...

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Bibliographic Details
Main Authors:	Chen, J, Stewart-Jones, G, Bossi, G, Lissin, N, Wooldridge, L, Choi, E, Held, G, Dunbar, P, Esnouf, R, Sami, M, Boulter, J, Rizkallah, P, Renner, C, Sewell, A, Van Der Merwe, P, Jakobsen, B, Griffiths, G, Jones, E, Cerundolo, V
Format:	Journal article
Language:	English
Published:	2005

Structural and kinetic basis for heightened immunogenicity of T cell vaccines.

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