Immune-related disease before and after vasectomy: an epidemiological database study.
BACKGROUND: Vasectomy can be followed by an autoimmune-antibody response. We aimed to determine whether men with immune-related diseases were more or less likely than others to have a vasectomy and then to determine whether vasectomy is associated with the subsequent development of immune-related di...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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2007
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| _version_ | 1826256509445603328 |
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| author | Goldacre, M Wotton, C Seagroatt, V Yeates, D |
| author_facet | Goldacre, M Wotton, C Seagroatt, V Yeates, D |
| author_sort | Goldacre, M |
| collection | OXFORD |
| description | BACKGROUND: Vasectomy can be followed by an autoimmune-antibody response. We aimed to determine whether men with immune-related diseases were more or less likely than others to have a vasectomy and then to determine whether vasectomy is associated with the subsequent development of immune-related diseases. METHODS: A database of linked records of hospital statistics was analysed. By comparing a population of men who underwent vasectomy with a reference population, we calculated the rate ratios for selected immune-related diseases before and after vasectomy. RESULTS: Some diseases studied (e.g. asthma and diabetes mellitus) were a little less common, prior to operation, in the vasectomy group than in the reference group. Others were not different. The mean period of follow-up was 13 years. We found no long-term elevation of risk following vasectomy of asthma, diabetes mellitus, ankylosing spondylitis, thyrotoxicosis, multiple sclerosis, myasthenia gravis, inflammatory bowel disease, rheumatoid arthritis or testicular atrophy. There was a short-term elevation of risk of orchitis/epididymitis. CONCLUSIONS: In this large study, with many years of follow-up, we found no evidence that vasectomy increases the subsequent long-term risk of immune-related diseases. |
| first_indexed | 2024-03-06T18:03:21Z |
| format | Journal article |
| id | oxford-uuid:009240dd-2180-4a4e-9e22-112072207216 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:03:21Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:009240dd-2180-4a4e-9e22-1120722072162022-03-26T08:30:15ZImmune-related disease before and after vasectomy: an epidemiological database study.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:009240dd-2180-4a4e-9e22-112072207216EnglishSymplectic Elements at Oxford2007Goldacre, MWotton, CSeagroatt, VYeates, DBACKGROUND: Vasectomy can be followed by an autoimmune-antibody response. We aimed to determine whether men with immune-related diseases were more or less likely than others to have a vasectomy and then to determine whether vasectomy is associated with the subsequent development of immune-related diseases. METHODS: A database of linked records of hospital statistics was analysed. By comparing a population of men who underwent vasectomy with a reference population, we calculated the rate ratios for selected immune-related diseases before and after vasectomy. RESULTS: Some diseases studied (e.g. asthma and diabetes mellitus) were a little less common, prior to operation, in the vasectomy group than in the reference group. Others were not different. The mean period of follow-up was 13 years. We found no long-term elevation of risk following vasectomy of asthma, diabetes mellitus, ankylosing spondylitis, thyrotoxicosis, multiple sclerosis, myasthenia gravis, inflammatory bowel disease, rheumatoid arthritis or testicular atrophy. There was a short-term elevation of risk of orchitis/epididymitis. CONCLUSIONS: In this large study, with many years of follow-up, we found no evidence that vasectomy increases the subsequent long-term risk of immune-related diseases. |
| spellingShingle | Goldacre, M Wotton, C Seagroatt, V Yeates, D Immune-related disease before and after vasectomy: an epidemiological database study. |
| title | Immune-related disease before and after vasectomy: an epidemiological database study. |
| title_full | Immune-related disease before and after vasectomy: an epidemiological database study. |
| title_fullStr | Immune-related disease before and after vasectomy: an epidemiological database study. |
| title_full_unstemmed | Immune-related disease before and after vasectomy: an epidemiological database study. |
| title_short | Immune-related disease before and after vasectomy: an epidemiological database study. |
| title_sort | immune related disease before and after vasectomy an epidemiological database study |
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