Interleukin-10 responses to therapeutic vaccination during highly active antiretroviral therapy and after analytical therapy interruption.
We investigated whether therapeutic vaccination in highly active antiretroviral therapy (HAART)-treated patients with a modified vaccinia virus Ankara-vectored HIV-1 vaccine, with or without therapy interruption, induced the production of interleukin (IL)-10. Plasma IL-10 levels were not significant...
| Những tác giả chính: | , , , , , , , , , |
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| Định dạng: | Journal article |
| Ngôn ngữ: | English |
| Được phát hành: |
2009
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| _version_ | 1826256521194897408 |
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| author | Yang, H Guimarães-Walker, A Hibbs, S Dong, T Stacey, A Borrow, P Hanke, T Davenport, M McMichael, A Dorrell, L |
| author_facet | Yang, H Guimarães-Walker, A Hibbs, S Dong, T Stacey, A Borrow, P Hanke, T Davenport, M McMichael, A Dorrell, L |
| author_sort | Yang, H |
| collection | OXFORD |
| description | We investigated whether therapeutic vaccination in highly active antiretroviral therapy (HAART)-treated patients with a modified vaccinia virus Ankara-vectored HIV-1 vaccine, with or without therapy interruption, induced the production of interleukin (IL)-10. Plasma IL-10 levels were not significantly increased postvaccination, but increased in parallel with viraemia in patients who interrupted therapy. Surprisingly, IL-10 blockade augmented HIV-specific T cell proliferative responses in HAART-suppressed patients but had no effect once virological control was lost. Modulation of IL-10 might enhance vaccine-induced immune responses. |
| first_indexed | 2024-03-06T18:03:32Z |
| format | Journal article |
| id | oxford-uuid:00a1dddd-9f8e-4a06-a407-9e07100fb549 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:03:32Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:00a1dddd-9f8e-4a06-a407-9e07100fb5492022-03-26T08:30:37ZInterleukin-10 responses to therapeutic vaccination during highly active antiretroviral therapy and after analytical therapy interruption.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:00a1dddd-9f8e-4a06-a407-9e07100fb549EnglishSymplectic Elements at Oxford2009Yang, HGuimarães-Walker, AHibbs, SDong, TStacey, ABorrow, PHanke, TDavenport, MMcMichael, ADorrell, LWe investigated whether therapeutic vaccination in highly active antiretroviral therapy (HAART)-treated patients with a modified vaccinia virus Ankara-vectored HIV-1 vaccine, with or without therapy interruption, induced the production of interleukin (IL)-10. Plasma IL-10 levels were not significantly increased postvaccination, but increased in parallel with viraemia in patients who interrupted therapy. Surprisingly, IL-10 blockade augmented HIV-specific T cell proliferative responses in HAART-suppressed patients but had no effect once virological control was lost. Modulation of IL-10 might enhance vaccine-induced immune responses. |
| spellingShingle | Yang, H Guimarães-Walker, A Hibbs, S Dong, T Stacey, A Borrow, P Hanke, T Davenport, M McMichael, A Dorrell, L Interleukin-10 responses to therapeutic vaccination during highly active antiretroviral therapy and after analytical therapy interruption. |
| title | Interleukin-10 responses to therapeutic vaccination during highly active antiretroviral therapy and after analytical therapy interruption. |
| title_full | Interleukin-10 responses to therapeutic vaccination during highly active antiretroviral therapy and after analytical therapy interruption. |
| title_fullStr | Interleukin-10 responses to therapeutic vaccination during highly active antiretroviral therapy and after analytical therapy interruption. |
| title_full_unstemmed | Interleukin-10 responses to therapeutic vaccination during highly active antiretroviral therapy and after analytical therapy interruption. |
| title_short | Interleukin-10 responses to therapeutic vaccination during highly active antiretroviral therapy and after analytical therapy interruption. |
| title_sort | interleukin 10 responses to therapeutic vaccination during highly active antiretroviral therapy and after analytical therapy interruption |
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