Expanding the utility of proteases in synthesis: broadening the substrate acceptance in non-coded amide bond formation using chemically modified mutants of subtilisin

Expanding the utility of proteases in synthesis: broadening the substrate acceptance in non-coded amide bond formation using chemically modified mutants of subtilisin

The strategy of combined site directed mutagenesis and chemical modification creates chemically modified mutants (CMMs) with greatly broadened substrate specificities. We have previously reported that the CMMs of subtilisin Bacillus lentus (SBL) are efficient catalysts for the coupling of both L- an...

Detaylı Bibliyografya
Asıl Yazarlar:	Khumtaveeporn, K, Ullmann, A, Matsumoto, K, Davis, B, Jones, J
Materyal Türü:	Journal article
Dil:	English
Baskı/Yayın Bilgisi:	2001

Benzer Materyaller

Glycosylation of the primary binding pocket of a subtilisin protease causes a remarkable broadening in stereospecificity in peptide synthesis
Yazar:: Matsumoto, K, ve diğerleri
Baskı/Yayın Bilgisi: (2001)

Chemically modified "polar patch" mutants of subtilisin in peptide synthesis with remarkably broad substrate acceptance: designing combinatorial biocatalysts.
Yazar:: Matsumoto, K, ve diğerleri
Baskı/Yayın Bilgisi: (2002)

Altering the specificity of subtilisin Bacillus lentus through the introduction of positive charge at single amino acid sites.
Yazar:: Davis, B, ve diğerleri
Baskı/Yayın Bilgisi: (1999)

Crystal structure of an intracellular subtilisin reveals novel structural features unique to this subtilisin family
Yazar:: Vévodová, J, ve diğerleri
Baskı/Yayın Bilgisi: (2010)

Subtilisin structure and catalysis in non-aqueous media
Yazar:: Schmitke, Jennifer L. (Jennifer Louise), 1971-
Baskı/Yayın Bilgisi: (2010)

Versatility of subtilisin: a review on structure, characteristics, and applications
Yazar:: Mohd Azrin, Nur Aliyah, ve diğerleri
Baskı/Yayın Bilgisi: (2022)

Site-selective glycosylation of subtilisin Bacillus lentus causes dramatic increases in esterase activity.
Yazar:: Lloyd, R, ve diğerleri
Baskı/Yayın Bilgisi: (2000)

Induction of IDO1 and kynurenine by serine proteases subtilisin, prostate specific antigen, CD26 and HtrA: a new form of immunosuppression?
Yazar:: Clanchy, FIL, ve diğerleri
Baskı/Yayın Bilgisi: (2022)

The controlled introduction of multiple negative charge at single amino acid sites in subtilisin Bacillus lentus.
Yazar:: Davis, B, ve diğerleri
Baskı/Yayın Bilgisi: (1999)

B-11 NMR-STUDIES OF AN ARYL BORONIC ACID BOUND TO CHYMOTRYPSIN AND SUBTILISIN
Yazar:: Baldwin, J, ve diğerleri
Baskı/Yayın Bilgisi: (1991)

Expanding the substrate scope in palladium-catalyzed C-N and C-C bond-forming reactions
Yazar:: Anderson, Kevin William
Baskı/Yayın Bilgisi: (2008)

Broadening heredity
Yazar:: Aylward, A
Baskı/Yayın Bilgisi: (2018)

The role of kinetics of water and amide bonding in protein stability
Yazar:: Porter, D, ve diğerleri
Baskı/Yayın Bilgisi: (2008)

Substrates and physiological functions of secretase rhomboids proteases
Yazar:: Freeman, M, ve diğerleri
Baskı/Yayın Bilgisi: (2016)

The structural basis for catalysis and substrate specificity of a rhomboid protease.
Yazar:: Vinothkumar, K, ve diğerleri
Baskı/Yayın Bilgisi: (2010)

Worksets expand the scholarly utility of digital libraries
Yazar:: Page, K, ve diğerleri
Baskı/Yayın Bilgisi: (2018)

Multimode Memories with Longitudinally Broadened Ensembles
Yazar:: Nunn, J, ve diğerleri
Baskı/Yayın Bilgisi: (2008)

Bacterial protease uses distinct thermodynamic signatures for substrate recognition.
Yazar:: Bezerra, G, ve diğerleri
Baskı/Yayın Bilgisi: (2017)

Rhomboid intramembrane proteases: from substrate specificity and mechanism to biological function
Yazar:: Strisovsky, K, ve diğerleri
Baskı/Yayın Bilgisi: (2009)

Expanding the substrate specificity of peptide asparaginyl ligase
Yazar:: Chua, Niying
Baskı/Yayın Bilgisi: (2023)

Mechanisms of substrate recognition by the AAA+ protease HslUV
Yazar:: Sundar, Shankar
Baskı/Yayın Bilgisi: (2011)

Specificity and regulation of substrate degradation for a AAA+ protease
Yazar:: Farrell, Christopher Mark
Baskı/Yayın Bilgisi: (2007)

Selective bi-directional amide bond cleavage of N-methylcysteinyl peptide
Yazar:: Qiu, Yibo, ve diğerleri
Baskı/Yayın Bilgisi: (2014)

Thermoplastic bonding of microfluidic substrates
Yazar:: Judge, Benjamin Michael
Baskı/Yayın Bilgisi: (2013)

USM BROADENS COLLABORATION WITH INDUSTRY
Yazar:: MPRC, Pusat Media & Perhubungan Awam
Baskı/Yayın Bilgisi: (2016)

Factorization and resummation for jet broadening
Yazar:: Becher, T, ve diğerleri
Baskı/Yayın Bilgisi: (2011)

NNLL Resummation for Jet Broadening
Yazar:: Becher, T, ve diğerleri
Baskı/Yayın Bilgisi: (2012)

Jet shapes with the broadening axis
Yazar:: Larkoski, Andrew, ve diğerleri
Baskı/Yayın Bilgisi: (2014)

Trophy hunting: broaden the debate
Yazar:: Bauer, H, ve diğerleri
Baskı/Yayın Bilgisi: (2019)

Spectral line broadening by plasmas /
Yazar:: 333468 Griem, Hans R.
Baskı/Yayın Bilgisi: (1974)

Vertical resolution and line broadening/
Yazar:: 454895 Monteath, G. D., ve diğerleri
Baskı/Yayın Bilgisi: (1962)

An endoglycosidase with alternative glycan specificity allows broadened glycoprotein remodelling.
Yazar:: Goodfellow, J, ve diğerleri
Baskı/Yayın Bilgisi: (2012)

Expanding the scope of substrate specificity for peptide asparaginyl ligases
Yazar:: Lim, Ching Koon
Baskı/Yayın Bilgisi: (2023)

Mechanism of active substrate delivery by the AAA+ protease adaptor CIpS
Yazar:: Rivera-Rivera, Izarys
Baskı/Yayın Bilgisi: (2016)

Substrate specificity, active-site residues, and function of the Tsp protease
Yazar:: Keiler, Kenneth Charles
Baskı/Yayın Bilgisi: (2007)

Multistep substrate binding and engagement by the AAA+ ClpXP protease
Yazar:: Saunders, Reuben A, ve diğerleri
Baskı/Yayın Bilgisi: (2021)

Substrate selection by the ClpXP protease : a tail of destruction
Yazar:: Flynn, Julia M., 1976-
Baskı/Yayın Bilgisi: (2005)

Mechanism-based traps enable protease and hydrolase substrate discovery
Yazar:: Tang, S, ve diğerleri
Baskı/Yayın Bilgisi: (2022)

Mass spectrometric assays monitoring the deubiquitinase activity of the SARS-CoV-2 papain-like protease inform on the basis of substrate selectivity and have utility for substrate identification
Yazar:: Brewitz, L, ve diğerleri
Baskı/Yayın Bilgisi: (2023)

Expanding the utility of lithiated epoxides and aziridines in synthesis
Yazar:: Hodgson, D, ve diğerleri
Baskı/Yayın Bilgisi: (2006)