Deletion of TASK1 and TASK3 channels disrupts intrinsic excitability but does not abolish glucose or pH responses of orexin/hypocretin neurons.

Deletion of TASK1 and TASK3 channels disrupts intrinsic excitability but does not abolish glucose or pH responses of orexin/hypocretin neurons.

The firing of hypothalamic hypocretin/orexin neurons is vital for normal sleep-wake transitions, but its molecular determinants are not well understood. It was recently proposed that TASK (TWIK-related acid-sensitive potassium) channels [TASK1 (K(2P)3.1) and/or TASK3 (K(2P)9.1)] regulate neuronal fi...

書誌詳細
主要な著者:	González, J, Jensen, LT, Doyle, SE, Miranda-Anaya, M, Menaker, M, Fugger, L, Bayliss, D, Burdakov, D
フォーマット:	Journal article
言語:	English
出版事項:	2009

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